Results 41 to 50 of about 403,757 (309)
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
Подільський вісник: сільське господарство, техніка, економікаAn important factor that determines the grain yield and productivity of corn is the previous crop. In the conditions of insufficient moisture in the Steppe region of Ukraine, the significance of the predecessor is determined by the accumulated moisture ...
Ю. В. Мащенко +2 more
doaj +1 more source
Corn yield, forage production and quality affected by methods of intercropping corn and Panicum maximum [PDF]
Pesquisa Agropecuária Brasileira, 2017 : The objective of this work was to evaluate methods of intercropping corn and Panicum spp. forages and their effects on corn yield and forage development. Two experiments with Panicum spp.
Rodrigo Estevam Munhoz de Almeida +5 more
doaj +1 more source
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
Phosphorus and Potassium Fertilizer Application Strategies in Corn–Soybean Rotations
Agronomy, 2018 To determine if current university fertilizer rate and timing recommendations pose a limitation to high-yield corn (Zea mays subsp. mays) and soybean (Glycine max) production, this study compared annual Phosphorous (P) and Potassium (K) fertilizer ...
Timothy J. Boring +8 more
doaj +1 more source
Short Season Corn Silage Variety Trial [PDF]
, 2013 In 2013, the University of Vermont Extension Northwest Crops and Soils Team evaluated yield and quality of short season corn silage varieties at Borderview Research Farm in Alburgh, VT.
Burke, Conner +4 more
core +1 more source
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Branches of Gliricidia sepium used as mulch for weed control in corn
Revista Ciência Agronômica, 2020 Mulching using crop residue reduces the growth of weeds and increases the yield of various crops. The aim of the present study was to evaluate the effects of Gliricidia sepium branches, used as mulch, on weed control, and on grain yield in corn.
Luiz Eduardo Barreto dos Santos +3 more
doaj +1 more source