Results 51 to 60 of about 410,319 (359)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Short Season Corn Silage Variety Trial [PDF]

, 2012
In 2012, the University of Vermont Extension Crops and Soils Team evaluated yield and quality of short season corn silage varieties at Borderview Research Farm in Alburgh, VT.
Burke, Conner, Cummings, Erica, Darby, Heather, Harwood, Hannah, Madden, Rosalie, Monahan, Susan   +5 more
core   +2 more sources

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Studies on Growth, Productivity and Economics of Baby Corn as Influenced by Crop Diversification of Baby Corn-based Cropping Systems

International Journal of Bio-Resource and Stress Management
A field experiment was conducted at the Agricultural Farm of Institute of Agriculture, Birbhum, West Bengal, India during winter from November to January of 2021–22 and 2022–23 respectively to evaluate growth, productivity and economics of baby corn as ...
Siddharth Shankar Patre, Arun Kumar Barik, Basant Kumar, Soumita Chowdhury, Sk Naim Aktar   +4 more
doaj   +1 more source

Impact of cattle grazing corn residue in spring on soil and subsequent soybean yield [PDF]

, 2023
Morgan Grabau, J. C. MacDonald, Zach E. Carlson, Mary E Drewnoski   +3 more
openalex   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Relationship of Simultaneous Cropping with Legumes and Application of Chemical and Biological Fertilizers with Agronomic Nitrogen Use Efficiency in Corn [PDF]

Journal of Agricultural Science and Sustainable Production, 2015
In order to evaluate the effect of simultaneous cropping with legumes and application of chemical and biological fertilizers on nitrogen agronomic efficiency of corn, this study was carried out in field of agricultural research of Arak Payame Noor ...
Mohammad Mirzakhani
doaj  

Short Season Corn Silage Variety Trial [PDF]

, 2016
In 2016, the University of Vermont Extension Northwest Crops and Soils Program evaluated yield and quality of short season corn silage varieties at Borderview Research Farm in Alburgh, VT.
Brigham, Nate, Cubins, Julija, Darby, Heather, Gupta, Abha, Ruhl, Lindsey, Ziegler, Sara   +5 more
core   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source