Results 121 to 130 of about 163,458 (264)

The Multiple Criteria Qualitative Value‐Based Pricing Framework “MARIE” for Novel Cell and Gene Therapy

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
When setting the price of cell and gene therapies in Japan, the factors considered include the manufacturing and operating costs of the new drug or a comparator, leading to discrepancies between price and values, in particular those specific to cell and gene therapies.
Akina Takami, Ataru Igarashi
wiley   +1 more source

Aquaporins in the Cornea

open access: yes
The cornea is an avascular, transparent tissue that allows light to enter the visual system. Accurate vision requires proper maintenance of the cornea’s integrity and structure.
Wendy B. Bollag, Samuel Melnyk
core   +1 more source

Low‐Dimensional Materials and Van Der Waals Heterostructures for Energy Application: A Comprehensive Review

open access: yesENERGY &ENVIRONMENTAL MATERIALS, EarlyView.
Low‐dimensional materials (0D, 1D, and 2D) exhibit unique electronic and physicochemical properties, enabling advanced nanoelectronic and optoelectronic devices. Mixed‐dimensional heterostructures combine these materials to enhance functionality.
Qaisar Alam   +3 more
wiley   +1 more source

Artificial Intelligence in Ophthalmology: From Methodological Advances to Clinical Translation and Future Directions

open access: yesEye &ENT Research, EarlyView.
ABSTRACT Artificial intelligence (AI) is reshaping ophthalmology from task‐specific image analysis toward multimodal, longitudinal, and clinically integrated decision support. This narrative review summarizes the methodological evolution of ophthalmic AI, including traditional machine learning, task‐specific deep learning, self‐supervised learning ...
Yuxin Liu, Hanruo Liu
wiley   +1 more source

Current and future therapies for treating corneal lesions

open access: yes, 2023
reservedLa cornea è lo strato più esterno dell’occhio, responsabile del passaggio del 95% della luce che incide la retina e fornisce circa il 70% del potere di focalizzazione dell’occhio. A causa della sua posizione anatomica è costantemente esposta a
BONATO, PIETRO
core  

Nanophotonic Biosensors and the Paradigm of Trans‐Scale Autonomous Bio‐Integrated Diagnostics for Addressing Health Complexities

open access: yesElectron, EarlyView.
Physics‐driven advances in optical nanobiosensors for rapid, miniaturized, and point‐of‐care diagnostics for next‐generation decentralized and personalized healthcare based on sensor intelligence. ABSTRACT Public health emergencies and the escalating burden of chronic diseases necessitate a paradigm shift from centralized laboratory testing to rapid ...
Vishal Chaudhary   +5 more
wiley   +1 more source

Inter-Municipal Cooperation – An Alternative Solution for The Amalgamation Projects?

open access: yesJournal of Danubian Studies and Research, 2017
Over the last three decades the Republic of Moldova has experienced several waves of reforms and counter-reforms. The governing political forces have implemented different reform strategies, mostly of them influenced by their political interest are ...
Sergiu Cornea
doaj  

Do preclinical seizure models predict success or failure in anti‐seizure drug development? A retrospective analysis of 89 compounds with divergent clinical outcomes for epilepsy

open access: yesEpilepsia, EarlyView.
Abstract Anti‐seizure medication (ASM) discovery remains a major challenge despite over 30 commercially available options. One persistent obstacle for any promising candidate compound to successfully move from preclinical study to clinical approval has been the ambiguity in preclinical model selection.
Wolfgang Löscher   +1 more
wiley   +1 more source

The Consequences of the Soviet Model of the Territorial Organization of Local Authorities in the Republic of Moldova: Until When?

open access: yesJournal of Danubian Studies and Research, 2015
In 1991, the Republic of Moldova became a sovereign state. By 1991, this country has had a Soviet administrative system which was characterized by excessive fragmentation of the territory.
Sergiu Cornea
doaj  

Comparative Analysis of the Intrinsic Disorder Within the Layers of the Human Cornea

open access: yes
The human cornea is essential for vision, providing structural integrity and refractive power to the eye. Recent advancements have deepened our understanding of the corneal molecular composition, yet the role of intrinsically disordered proteins within ...
Kim, Colin   +7 more
core   +1 more source

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