Results 231 to 240 of about 228,160 (345)

Nature Inspired Delivery Vehicles for CRISPR‐Based Genome Editing

Small, EarlyView.
The review highlights nature‐inspired nanocarriers for CRISPR delivery, emphasizing viral vectors, extracellular vesicles, liposomes, and lipid nanoparticles. It discusses their roles in improving specificity, minimizing immunogenicity, and overcoming barriers in genome editing. Recent advancements, challenges, and therapeutic applications are explored,
Elizabeth Maria Clarissa, Mamata Karmacharya, Hyunmin Choi, Sumit Kumar, Yoon‐Kyoung Cho   +4 more
wiley   +1 more source

Nerves and neovessels inhibit each other in the cornea.

Investigative Ophthalmology and Visual Science, 2013
G. Ferrari, A. Hajrasouliha, Zahra Sadrai, Hiroki Ueno, S. Chauhan, R. Dana   +5 more
semanticscholar   +1 more source

Corneal Nerve Regeneration via MSC‐Derived EVs: Tissue Source and Culture Dimensionality Dictate miRNA Cargo and Therapeutic Efficacy

Small, EarlyView.
Mesenchymal stem cell‐derived extracellular vesicles (EVs) from human cornea and bone marrow, cultured in 2D and 3D conditions, are characterized and tested for corneal nerve repair. 3D‐derived EVs show superior therapeutic efficacy and in vivo reinnervation.
Hamed Massoumi, Eitan A. Katz, Melinda Alviar, Qiang Zhou, Mauricio Gonzalez Oyarzun, Deepshikha Tewari, Makayla Dove, Hanieh Niktinat, Tara Nguyen, Seyed Mahbod Baharnoori, Khandaker Anwar, Mark Maienschein Cline, Yuanxiang Li, Xiaowei Wang, Victor H. Guaiquil, Mark I. Rosenblatt, Ali R. Djalilian, Elmira Jalilian   +17 more
wiley   +1 more source

Advances in Cornea [PDF]

The Open Ophthalmology Journal, 2018
openaire   +2 more sources

Hydrogel Microspheres for Biomedical Applications

Small Science, EarlyView.
Hydrogel microspheres (HMs) play pivotal roles in biomedical applications, such as drug delivery, cell culture, regenerative medicine, wound healing, and tumor immunity. This review focuses on the latest findings to provide a more comprehensive understanding of HMs for biomedical applications.
Yingkang Huang, Xi Zhu, Jinhong Zhou, Henan Li, Wei Zhang, Danyang Shen, Ziyan Huang, Tianbo Zhang, Lin Zhuang, Lei Qin, Xiaofeng Xue, Yunjie Lu   +11 more
wiley   +1 more source

The cornea--structure and macromolecules in health and disease. A review.

, 1977
Klintworth Gk
openalex   +1 more source

Lipid Nanoparticles for Delivery of CRISPR Gene Editing Components

Small Methods, EarlyView.
The review presents a comprehensive overview of each component of lipid nanoparticles（LNPs）and their effects on editing efficiency. It specifically highlights strategies for achieving non‐liver delivery, aiming for broader applications in gene editing. Furthermore, this review summarizes the applications of LNPs in gene editing and offers insights for ...
Fan Wu, Nei Li, Yudian Xiao, Rohan Palanki, Hannah Yamagata, Michael J. Mitchell, Xuexiang Han   +6 more
wiley   +1 more source

Prediction of cell states and key transcription factors of the human cornea through integrated single-cell omics analyses

J.A. Arts, Sofia Fallo, Melanie S. Florencio, Jos G.A. Smits, Dulce Lima Cunha, Janou A. Y. Roubroeks, Mor M. Dickman, Vanessa L.S. LaPointe, Rosemary Yu, Huiqing Zhou   +9 more
openalex   +1 more source

The structure and transparency of the cornea

Journal of Physiology, 1957
D. Maurice
semanticscholar   +1 more source

Targeted Therapy of Fungal Keratitis Enabled by Iron Nutritional Deprivation Combined With Photothermal Effect

Small Structures, EarlyView.
This work developed a PDC nanoplatform that orchestrated a multimodal synergistic therapy, combining active targeting, photothermal therapy, and iron nutrient deprivation. The antifungal, anti‐inflammatory efficacy and corneal repair ability of nanoplatform were demonstrated through both in vitro and in vivo evaluations.
Ruojiao Feng, Lingshuai Meng, Shuping Zhang, Jie Zhang, Chuchu Hu, Jiaxin Zhang, Junchao Xia, Xiaoshuo Yue, Quanlin Wang, Xiaoran Liu, Wenruo Xu, Yinglun Sun, Panhong Niu, Hua Gao   +13 more
wiley   +1 more source