Results 61 to 70 of about 136,945 (289)

A Rare De Novo Missense Mutation in IFT122 Confers a Genetic Susceptibility Factor of Idiopathic Pediatric Uveitis Via Trio‐based Whole‐Exome Sequencing

Advanced Science, EarlyView.
A rare de novo IFT122‐A773E variant is identified in idiopathic pediatric uveitis and shown to exacerbate retinal inflammation and barrier dysfunction. Mechanistically, the variant enhances IFT43 interaction, elevates calcium signaling, and activates the MEK/ERK/FRA1 axis, revealing a previously unrecognized cilia‐associated pathway that may increase ...
Qian Zhou, Jiaxing Huang, Yilin Wang, Xingran Li, Xianyang Liu, Lingyu Dai, Hongshun Li, Qingfeng Wang, Jiangyi Liu, Guannan Su, Wanyun Zhang, Yang Deng, Qingfeng Cao, Yujie Lai, Xiang Luo, Changwei Huang, Ling Chen, Shengping Hou, Peizeng Yang   +18 more
wiley   +1 more source

Analysis of third and fourth corneal high-order aberrations before and after small incision lenticule extraction (SMILE) in myopic and myopic astigmatic eyes using ray tracing aberrometry

Beni-Suef University Journal of Basic and Applied Sciences
Background Aim is to analyze alterations in third and fourth corneal higher-order aberrations using a ray tracing aberrometer (iTrace) induced by SMILE (small incision lenticule extraction) refractive surgery on Algerian patients; and also to investigate
Sarra Belgacem, Saoussene Habani, Daoud Guernazi, Fatiha Kail, Selma Chiali   +4 more
doaj   +1 more source

ROS‐Responsive Eye Drop for Controlled Release of 20‐Deoxyingenol Improves Diabetic Corneal Healing by Activating Macrophage Autophagy and Metabolic Reprogramming

Advanced Science, EarlyView.
Schematic illustration of ROS‐responsive TSPBA‐PVA microspheres loaded with 20‐deoxyingenol (TP/20‐DOI) for diabetic corneal wound healing: (a) fabrication and ROS‐triggered release; (b) autophagy activation and metabolic reprogramming in macrophages; (c) suppression of macrophage‐derived CXCL3/CXCL5, attenuation of neutrophil infiltration, and ...
Jiaxin Wu, Wanying Chen, Haijiang Qiu, Weihan Zheng, Ying Jiao, Jingheng Du, Zhudan Zhuang, Xing Hua, Jingyi Gu, Yuheng Liu, Zhaojin Li, Jingbin Xie, Hanxiao Sun, Huifei Lan, Xin Sun, Yunxia Xue, Ting Fu, Zhijie Li, Guobing Chen, Shiyu Li, Jun Liu   +20 more
wiley   +1 more source

Corneal higher-order aberrations in corneal endothelial decompensation secondary to obstetric forceps injury

Scientific Reports, 2023
Forceps corneal injuries during infant delivery cause Descemet membrane (DM) breaks, that cause corneal astigmatism and corneal endothelial decompensation.
Hirotsugu Kasamatsu, Yukari Yagi-Yaguchi, Takefumi Yamaguchi, Sota Nishisako, Toshinori Murata, Jun Shimazaki   +5 more
doaj   +1 more source

Potential of Nanoparticle‐Based Phototherapies for Future Treatment of Uveal Melanoma

Advanced Science, EarlyView.
This review evaluates nanoparticle‐based phototherapies for uveal melanoma, highlighting emerging strategies to enhance tumor targeting, light delivery, and treatment precision. Preclinical data indicate improved efficacy and reduced toxicity, supporting their potential to enhance localized treatment and future translational advances. (Generated by the
Emilie Lambert, Christophe Nguyen, Sean Edward Dunn, Magali Gary‐Bobo, Jérôme Lacombe, Justin Moser, Frédéric Zenhausern, Jean‐Olivier Durand, Frédérique Cunin   +8 more
wiley   +1 more source

Comparison between Wavefront-optimized and corneal Wavefront-guided Transepithelial photorefractive keratectomy in moderate to high astigmatism

BMC Ophthalmology, 2018
Background To compare the clinical outcomes of wavefront-optimized (WFO) transepithelial photorefractive keratectomy (trans-PRK) and corneal wavefront-guided (CWFG) trans-PRK for myopic eyes with moderate to high astigmatism.
Ikhyun Jun, David Sung Yong Kang, Samuel Arba-Mosquera, Jin Young Choi, Hyung Keun Lee, Eung Kweon Kim, Kyoung Yul Seo, Tae-im Kim   +7 more
doaj   +1 more source

Electronics‐Free Visual Monitoring of Dry Eye Disease‐Related Tear Biomarkers Using Smart Scleral Lenses

Advanced Science, EarlyView.
An electronics‐free smart scleral lens passively monitors dry eye disease‐related tear biomarkers through colorimetric sensing of chloride, pH, and ocular surface temperature. Smartphone‐assisted image analysis enables quantitative interpretation, providing a simple, non‐invasive strategy for ocular health monitoring without integrated electronics ...
Ziheng Wang, Sang Mok Park, Dawn Meyer, Seul Ah Lee, Yumin Dai, Tianhao Yu, Taewoong Park, Feiyang Li, Jason Gerard Jedlicka, Tristan Michael Long, Oluwabunmi T. Oladele, Gillian C. Shaw, Shin Ae Park, Pete S. Kollbaum, Young L. Kim, Chi Hwan Lee   +15 more
wiley   +1 more source

Effect of age on components of peripheral ocular aberrations [PDF]

, 2012
Purpose: \ud To investigate the effect of age on the contributions of the anterior cornea and internal components to ocular aberrations in the peripheral visual field.
Mathur, Ankit, Atchison, David A.
core   +1 more source

OAF Blocks SIAH1‐Mediated Degradation of SCPX, a Therapeutic Strategy for MASLD

Advanced Science, EarlyView.
This study shows OAF directly binds to SCPX and inhibits its interaction with the E3 ligase SIAH1, thereby protecting SCPX from ubiquitin‐dependent degradation and stabilizing its levels. This OAF‐SCPX axis represents a novel pathway in lipid homeostasis, highlighting OAF as a promising therapeutic candidate for MASLD.
Zongxi Li, Jingyue Song, Kaili Ma, Shunan Tang, Shuqian Wang, Wenya Ji, Chen Lu, Ting Zhang, Huaping Zheng, Xiaowei Zheng, Shanshan Lai, Cheng Deng   +11 more
wiley   +1 more source

Ultra-High Resolution Optical Aberrometry in Patients with Keratoconus: A Cross-Sectional Study

Ophthalmology and Therapy, 2023
Introduction This study performs optical aberration assessment in patients using a novel ultra-high-resolution device. The objective of this study is to analyze optical aberrations, especially the very high order wavefront (more than 10th order of ...
Gonzalo Velarde-Rodriguez, Carolina Belda-Para, Miriam Velasco-Ocaña, Juan M. Trujillo-Sevilla, Javier Rodríguez-Martin, Ignacio Jiménez-Alfaro, José M. Rodriguez-Ramos, Nicolas Alejandre-Alba   +7 more
doaj   +1 more source