Results 101 to 110 of about 9,890 (252)

Diabetic Peripheral Neuropathy: Molecular Staging, Risk Factors, Therapeutics, and Emerging Trends

Med Research, EarlyView.
The heterogeneous landscape of DPN can be unified through a tripartite pathogenic model encompassing progressive stages of metabolic dysregulation, chronic inflammation, and overt neuronal damage. Within this framework, six clinical subtypes were identified, namely, hyperglycemia‐driven, dyslipidemia‐driven, inflammation‐driven, dysvascularity‐driven ...
Xiaofeng Dai, Mingze Tang
wiley   +1 more source

ELECTRON MICROSCOPY OF THE CORNEAL STROMA AFTER THE STANDARD CROSS-LINKING AND USING FEMTOSECOND LASER IN EXPERIMENT

Офтальмохирургия, 2015
Purpose. The study and comparison of the corneal tissues condition after the standard corneal collagen cross-linking (CXL) and femto-cross-linking in experiment.Material and methods.
V. V. Zotov, N. P. Pashtayev, E. V. Larionov, N. A. Pozdeyeva, S. I. Anisimov   +4 more
doaj  

Biodegradable Natural Polymer‐Based Drug Delivery Systems for Bone Tissue Engineering

Medicinal Research Reviews, EarlyView.
ABSTRACT The increasing incidence of bone diseases and injuries, especially among aging populations, has underscored the shortcomings of traditional treatments such as bone grafts and metal implants, which often face complications including immune rejection, mechanical failure, and delayed healing.
Hyejin Jo, Shinwon Kang, Jae Eun Yang, Inseon Kim, Seunghun S. Lee   +4 more
wiley   +1 more source

Microglial Activation Under Hypoxic Conditions in Early Alzheimer's Disease: Can Natural SIRT1 Activators Be Therapeutic Allies in the Inflammation–Energy Axis?

Phytotherapy Research, EarlyView.
ABSTRACT Alzheimer's disease (AD) is a progressive neurodegenerative condition characterized by a preclinical stage that typically lasts for decades. Early on during this time, microglia react to pathological changes and become protective and even transiently delay neurodegeneration.
Sara Merlo, Cristiana Lucia Rita Lipari, Aurora Patti, Maria Angela Sortino   +3 more
wiley   +1 more source

Unlocking the potential of stimuli‐responsive liquid crystal polymer bio‐interfaces for adaptive cell modulation

Responsive Materials, EarlyView.
This Perspective discusses the potential of stimuli‐responsive liquid crystal polymer bio‐interfaces in modulating cell behavior as next generation dynamic artificial scaffolds. Unlike current artificial biomaterials that have static properties, LCPs offer fast, reversible, and spatially programmable deformation that reflects the dynamic properties of ...
Ruth M. C. Verbroekken, Burcu Gumuscu, Albert P. H. J. Schenning   +2 more
wiley   +1 more source

Fiber Bragg Grating Force Sensors for Minimally Invasive Surgery: State of the Art, Challenges, and Opportunities

SmartBot, EarlyView.
This article reviews the application of fiber Bragg grating (FBG) technology for precise force sensing in minimally invasive surgery. It outlines the fundamental working principles and algorithms used to interpret sensor data. The text surveys clinical applications across various medical fields, such as ophthalmology and vascular intervention (Table of
Shiyuan Dong, Tianqi Huang, Lingyu Chen, Shucong Yin, Qing Chang, Dingpei Han, Yangxi Li, Boyu Zhang, Hongen Liao, Fang Chen   +9 more
wiley   +1 more source

Assessing a Model for a Complex Systemic Disorder—The Value of Male Mice With a Supernumerary X Chromosome for Klinefelter Syndrome Research

Andrology, EarlyView.
ABSTRACT Introduction Direct experimental investigation of Klinefelter syndrome (KS) in patients is limited because the syndrome manifests heterogeneously and affects multiple organ systems. Studying KS therefore requires a model that captures this complexity as accurately as possible while still permitting controlled experimental manipulation ...
Fariba Saadati, Joachim Wistuba
wiley   +1 more source

Clinical recommendations for early identification of patients with open‐angle glaucoma at higher risk of low adherence to topical treatment: An Italian Delphi consensus

Acta Ophthalmologica, EarlyView.
Abstract Purpose It is important for clinicians to identify patients with glaucoma at higher risk of poor adherence to topical therapy at an early stage to prescribe alternative treatments. An expert‐based set of statements was developed to assist clinicians in the early identification of patients at high risk of low adherence and subsequent poorer ...
Roberto G. Carassa, Giovanni Pomponio, Luca Agnifili, Antonio Maria Fea, Michele Iester, Giorgio Marchini, Enrico Martini, Stefano Miglior, Francesco Oddone, Luca Rossetti, Matteo Sacchi, Carlo Enrico Traverso, Michele Figus   +12 more
wiley   +1 more source

Occupational exposure to metal welding and cataract: A systematic review and meta‐analysis

Acta Ophthalmologica, EarlyView.
Abstract Background Metal welding generates ultraviolet radiation (UVR) of cataractogenic wavelengths, and UVR emitted during welding has been associated with cataract formation, but results from prior studies are conflicting. Methods We conducted a systematic review and meta‐analysis of epidemiological studies addressing associations between ...
Jakob Bjerager, Esben Meulengracht Flachs, Martin Nissen Hermann, Jens Peter Ellekilde Bonde, Ingrid Sivesind Mehlum, Stinna Skaaby   +5 more
wiley   +1 more source

Infection control in the brain and the eye

Acta Ophthalmologica, EarlyView.
Abstract The Central Nervous System (CNS), comprising the brain and the eye, is considered to have a ‘privileged’ mechanism for dealing with immunological challenge (immune privilege, IP). CNS IP has been revealed through experiments using foreign protein antigens and cell and tissue alloantigens (grafts), but evidence for a role for IP in modulating ...
John V. Forrester, Paul G. McMenamin, Samantha J. Dando   +2 more
wiley   +1 more source