Results 111 to 120 of about 186,523 (222)

Collagen XII Plays a More Prominent Cell‐Mediated Role in Tendon Organization Compared to Matrix Assembly During Postnatal Development

The FASEB Journal, Volume 39, Issue 21, 15 November 2025.
Temporal roles of collagen XII in regulating cell and matrix organization during tendon development were investigated by tendon‐targeted knockout throughout development and induced knockdown at birth. Tendon‐targeted knockout disrupted patellar tendon morphology, cell and matrix organization, and mechanical properties.
Ashley K. Fung, Stephanie N. Weiss, Courtney A. Nuss, William Yen, Susan W. Volk, Nathaniel A. Dyment, Louis J. Soslowsky   +6 more
wiley   +1 more source

Regional corneal biomechanics assessment as a function of age using Strain–Stress Index maps

Ophthalmic and Physiological Optics, Volume 45, Issue 7, Page 1773-1779, November 2025.
Abstract Purpose To gain a better understanding of corneal Stress–Strain Index (SSI) maps in healthy eyes and to determine their changes with age. Method The eyes of 72 participants (age 43.1 ± 20.9 years, 69.5% female) were included in the analysis, considering the left and right eyes separately.
Vahoura Tahsini, Marta Jiménez‐García, Ahmed Makarem, Ahmed Elsheikh, Philippe Büchler, Sabine Kling, Jos J. Rozema   +6 more
wiley   +1 more source

Differential Quantitative Proteomics of Human Microvascular Endothelial Cells 1 by iTRAQ Reveals Palladin to be a New Biomarker During TGF-β1 Induced Endothelial Mesenchymal Transition [PDF]

, 2017
The study uses global quantitative proteomics to investigate the molecular mechanisms behind the induction of endothelial-mesenchymal transition (EndMT) by transforming growth factor–β (TGF-β).
Bednarek, Radosław, Gawryś, Katarzyna, Popielarsk, Marcin, Sitkiewicz, Ewa, Stasiak, Marta, Studzian, Maciej, Swiatkowska, Maria, Szemraj, Janusz   +7 more
core   +1 more source

Small Molecule Targeting of Atypical p38 Protects Against Viral Infection

The FASEB Journal, Volume 39, Issue 20, 31 October 2025.
Targeting host signaling pathways offers a complementary strategy to direct‐acting antivirals. Small‐molecule modulators of atypical p38 block Hepatitis C virus replication and also inhibit Human Cytomegalovirus. By disrupting virus‐induced p38 activation, these compounds suppress viral RNA replication and protein expression, highlighting atypical p38 ...
Fredejah T. Royer, Jeremy C. Burton, Johnathan Burns, Megan G. Lloyd, Reuben Onwe, Jennifer F. Moffat, Neil J. Grimsey   +6 more
wiley   +1 more source

Subconjunctival Injection of XG-102, a c-Jun N-Terminal Kinase Inhibitor Peptide, in the Treatment of Endotoxin-Induced Uveitis in Rats. [PDF]

, 2015
Purpose: XG-102, a TAT-coupled dextrogyre peptide inhibiting the c-Jun N-terminal kinase, was shown efficient in the treatment of experimental uveitis. Preclinical studies are now performed to determine optimal XG-102 dose and route of administration in ...
Abadie, C., Behar-Cohen, F., Berdugo, M., Combette, J.M., Deloche, C., El Zaoui, I., Kowalczuk, L., Naud, M.C., Touchard, E., Zhao, M.   +9 more
core   +2 more sources

Endothelial MEMO1 Regulates Angiogenic Signaling in a Model of Retinopathy of Prematurity

FASEB BioAdvances, Volume 7, Issue 9, September 2025.
Vascular endothelial growth factor (VEGF) drives both normal and pathological angiogenesis in retinopathy of prematurity (ROP). In a rat ROP model, MEMO1 was identified as a regulator of VEGF signaling in retinal microvascular endothelial cells (RMVECs).
Aniket Ramshekar, Bright Asare‐Bediako, Jasmine Nguyen, Arundhathy Suresh, Aaron Simmons, Colin A. Bretz, Haibo Wang, Eric Kunz, Chandler J. Zaugg, Chris Wallace‐Carrete, M. Elizabeth Hartnett   +10 more
wiley   +1 more source

Corneal clarity measurements in patients with keratoconus undergoing either penetrating or deep anterior lamellar keratoplasty

Clinical Ophthalmology, 2018
Khaled Alzahrani,1,2 Syarifah-Faiza Dardin,1 Fiona Carley,2 Arun Brahma,2 Debbie Morley,2 M Chantal Hillarby1 1Division of Pharmacy and Optometry, School of Health Sciences, University of Manchester, Manchester, UK; 2Manchester Royal Eye Hospital ...
Alzahrani K, Dardin SF, Carley F, Brahma A, Morley D, Hillarby MC   +5 more
doaj  

Inhibition of cyclin-dependent kinase 7 down-regulates yes-associated protein expression in mesothelioma cells. [PDF]

, 2020
Cyclin-dependent kinase 7 (CDK7) is a protein kinase that plays a major role in transcription initiation. Yes-associated protein (YAP) is a main effector of the Hippo/YAP signalling pathway.
Bin, Hu, Chan, Geraldine, Jablons, David M, Kyoyama, Hiroyuki, Li, Hui, Liu, Luwei, Liu, Shu, Miao, Jinbai, Urisman, Anatoly, Wang, Yucheng, Xu, Zhidong, Yang, Yi-Lin, You, Liang   +12 more
core  

Transforming Growth Factor Beta 1 drives a switch in connexin mediated cell-to-cell communication in tubular cells of the diabetic kidney [PDF]

, 2018
Aims/Hypothesis: Changes in cell-to-cell communication have been linked to several secondary complications of diabetes, but the mechanism by which connexins affect disease progression in the kidney is poorly understood.
Hills, C. E., Kauffman, T. J., Price, G. W., Squires, Paul, Tang, S. C., Wall, M. J., Yiu, W. H.   +6 more
core   +4 more sources

Preferential Myosin Heavy Chain Isoform B Expression May Contribute to the Faster Velocity of Contraction in Veins versus Arteries [PDF]

, 2007
Smooth muscle myosin heavy chains occur in 2 isoforms, SMA (slow) and SMB (fast). We hypothesized that the SMB isoform is predominant in the faster-contracting rat vena cava compared to thoracic aorta.
Eddinger, Thomas, Fink, Gregory D, Kayal, Anas, Rondelli, Catherine M, Rovner, Arthur S, Szasz, Irina T, Thakali, Keshari, Watson, Ralph E, Watts, Stephanie W   +8 more
core   +1 more source