Results 21 to 30 of about 200,407 (146)

Molecular Pathogenesis of Corneal Dystrophies: Schnyder Dystrophy and Granular Corneal Dystrophy type 2

, 2015
The International Committee for Classification of Corneal Dystrophies (IC3D) provides updated data to ophthalmologists by incorporating traditional definitions of corneal dystrophies with new genetic, clinical, and pathologic information. Recent advances
최승일, 이훈, 김응권
core   +1 more source

Congenital Dystrophy of the Epithelial Basement Membrane in a Child. Clinical Case

Oftalʹmologiâ
Corneal dystrophy (CD) is a large group of genetically determined diseases involving one or more corneal layers. It has a progressive course and is not associated with external or systemic factors.
A. V. Pleskova, V. R. Getadaryan
doaj   +1 more source

Distrofia corneana policromática posterior Polychromatic posterior corneal dystrophy

Revista Brasileira de Oftalmologia, 2007
Os autores descrevem quatro raros casos de distrofia corneana policromática posterior, ainda não descrito na literatura nacional. Observam-se opacidades puntiformes, policromáticas, de tamanho uniforme, localização estromal profunda, distribuídas de ...
Patrick Frensel de Moraes Tzelikis, Ulisses Roberto dos Santos, Marco Antônio Guarino Tanure, Fernando Cançado Trindade   +3 more
doaj   +1 more source

The First Experience of Hereditary Epithelial-stromal Corneal Dystrophies Combined Treatment

Oftalʹmologiâ
Purpose: to evaluate the results of combined treatment of hereditary epithelial-stromal corneal dystrophies. Patients and methods. The study included 5 patients with hereditary epithelial-stromal corneal dystrophies (HESCD), 8 of whom underwent ...
I. V. Vasilieva, A. Yu. Slonimsky, A. V. Vasiliev   +2 more
doaj   +1 more source

Navigating the Complexity: A Comprehensive Review of GSK‐3 Inhibition in Regenerative Medicine

Medicinal Research Reviews, EarlyView.
ABSTRACT Glycogen synthase kinase‐3 (GSK‐3) is a central regulator of numerous cellular signaling pathways, with critical roles in metabolism, proliferation, differentiation, and tissue regeneration. This review explores the multifaceted effects of pharmacological GSK‐3 inhibition across multiple body districts, focusing on its highly context‐dependent
Davide Schiroli, Alessia Merra, Chiara Marraccini, Lucia Merolle, Graziella Pellegrini, Eleonora Maurizi   +5 more
wiley   +1 more source

Microscopia confocal no auxílio diagnóstico de Distrofia Corneana de Schnyder

Revista Brasileira de Oftalmologia
Resumo Neste relato, descrevemos um caso de Distrofia corneana de Schnyder que apresentou o desfecho de seu diagnóstico baseado em achados característicos na microscopia confocal, ferramenta que se aponta em destaque no universo oftalmológico.
Débora Biazim, Diego Casagrande, Paula Kataguiri   +2 more
doaj   +1 more source

Genetic risk factors in Finnish patients with Fuchs endothelial corneal dystrophy

Acta Ophthalmologica, EarlyView.
Abstract Purpose To study the genetic risk factors of Fuchs endothelial corneal dystrophy (FECD) in the Finnish population using hospital‐based and large biobank cohorts. Methods We genotyped a cohort of 107 Finnish patients with FECD for the primary associated genetic risk factor, the TCF4 (CTG)>50 expansion, and studied their clinical phenotype.
Inka‐Tuulevi Vähämäki, Annamari T. Immonen, Joel T. Rämö, Aino M. Jaakkola, Kari Krootila, Maria Kaukonen, FinnGen, Aarno Palotie, Hannes Lohi, Tero T. Kivelä, Joni A. Turunen   +10 more
wiley   +1 more source

Corneal transplantation: Restoring sight to the blind

Acta Ophthalmologica, EarlyView.
Abstract Corneal blindness is one of the leading causes of vision loss worldwide. Transplantation of the cornea can restore vision and make blind patients see again. Corneal transplant surgery has undergone major evolution in recent decades with the advent of minimally invasive lamellar surgical approaches such as DMEK and DALK.
Claus Cursiefen
wiley   +1 more source

Dystrophia Smolandiensis is characterized by a novel NQO1 variant and a distinct phenotype from COL17A1‐associated epithelial recurrent erosion dystrophy

Acta Ophthalmologica, EarlyView.
Abstract Purpose To determine the molecular cause of the two epithelial recurrent erosion dystrophies, Dystrophia Smolandiensis and Dystrophia Helsinglandica, and to identify phenotypic differences between the two conditions. Methods DNA samples and clinical data from structured interview records were obtained from the Swedish families in which ...
Karl De Geer, Kristina Lagerstedt‐Robinson, Daniel Nilsson, Cilla Söderhäll, Björn Hammar, Erik Björck   +5 more
wiley   +1 more source

The IC3D Classification of the Corneal Dystrophies

, 2008
Background: The recent availability of genetic analyses has demonstrated the shortcomings of the current phenotypic method of corneal dystrophy classification. Abnormalities in different genes call Cause a single phenotype, whereas different defects in a
Kivela, T, Weiss, Jayne S., Lisch, Walter, Klintworth, Gordon K., Belin, MW, Busin, M, Lisch, W, Sutphin, John, Rapuano, Christopher J., Kim, Eung Kweon, Kinoshita, Shigeru, Aldave, Anthony J., Kivelä, Tero, Mà ̧ller, H. U., Seitz, Berthold, Aldave, AJ, Kinoshita, S, Bredrup, Cecilie, Belin, Michael W., Mannis, MJ, Moller, HU, Bredrup, C, Munier, FL, Busin, Massimo, Sutphin, J, Van Rij, Gabriel, Seitz, B, Munier, Francis L., Weiss, JS, Rapuano, CJ, Rij, G., Klintworth, GK, Kim, EK, Mannis, Mark J., Munier, F.L., Klintworth, G.K., Kim, E.K., Rapuano, C.J., Kinoshita, S., Kivelä, T., Aldave, A.J., Van Rij, G., Mannis, M.J., Belin, M.W., Seitz, B., Busin, M., Weiss, J.S., Lisch, W., Bredrup, C., Møller, H.U., Sutphin, J.   +50 more
core   +1 more source