Results 121 to 130 of about 218,547 (221)

Endothelial Exostosin‐1 Is Needed for Glycocalyx Integrity and Inflammatory Resolution in Acute Lung Injury

The FASEB Journal, Volume 40, Issue 19, 15 October 2026.
Endothelial Ext1 is essential for maintaining heparan sulfate–rich endothelial glycocalyx integrity. Loss of Ext1 reduces glycocalyx thickness, resulting in enhanced leukocyte adhesion, increased vascular permeability, and exaggerated inflammatory responses following lipopolysaccharide (LPS) challenge.
Yuki Kawasaki, Hiroyuki Tomita, Kodai Suzuki, Chihiro Takada, Hirotaka Asano, Soichiro Kano, Yugo Wakayama, Hirotsugu Fukuda, Toru Minamiyama, Genki Yoshimura, Ryo Kamidani, Yoshinori Kakino, Tomotaka Miura, Yuichiro Kitagawa, Tetsuya Fukuta, Takahito Miyake, Akio Suzuki, Kazu Matsumoto, Nobuyuki Tetsuka, Shozo Yoshida, Yoichi Maekawa, Yu Yamaguchi, Hideshi Okada   +22 more
wiley   +1 more source

From Molecular Targets to Advanced Delivery Systems: Aptamers for Precision Ocular Therapeutics

Advanced Therapeutics, Volume 9, Issue 10, October 2026.
Aptamer‐based strategies are revolutionizing ocular disease management through highly specific molecular recognition of disease specific molecular targets. This review systematically integrates therapeutic aptamer sequences, diagnostic aptasensor platforms, and targeted delivery strategies, highlighting design principles, ocular bioavailability ...
Minal Thacker, Ka‐Ying Wong, Liping Zhou, Man‐Sau Wong, Juewen Liu   +4 more
wiley   +1 more source

Successful Empirical Treatment of a Severe Corneal Abscess After Delayed Consultation in a Low‐Resource Setting: A Case Report

Clinical Case Reports, Volume 14, Issue 10, October 2026.
ABSTRACT Corneal abscesses remain an important cause of preventable monocular blindness, particularly where access to specialized eye care is limited. We report a 34‐year‐old man from the Democratic Republic of the Congo who presented with a severe corneal abscess after three weeks of symptoms and prior self‐medication with unidentified topical eye ...
Gloria Nshokano Simba, Fidele Kabego Kulimushi, Christian Mwetaminwa Iyimba, Roméo Bujiriri Murhega   +3 more
wiley   +1 more source

Quercetin Attenuates Cisplatin‐Induced Nephrotoxicity While Enhancing Antitumor Efficacy in Gastric Cancer via Cell Type‐Specific Modulation of the ERK1/2 Pathway

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 10, October 2026.
Quercetin alleviates cisplatin‐induced nephrotoxicity while enhancing antitumor efficacy in gastric cancer. ERK1/2 pathway inhibition mediates cell type‐specific downstream effects of quercetin. Quercetin is a promising adjunct to cisplatin‐based chemotherapy for gastric cancer.
Gen Xia, Shuning Gu, Xiaojie Li, Kun Li, Shizheng Li   +4 more
wiley   +1 more source

Iron and Other Metal Ions in Human Health and Disease

MedComm, Volume 7, Issue 10, October 2026.
Iron, copper, zinc, and calcium orchestrate cellular function through distinct yet cooperative mechanisms: redox‐active iron and copper cycle between oxidation states to act as Fenton catalysts and electron carriers in oxidative phosphorylation (OXPHOS); redox‐inert zinc serves as a structural component of zinc‐finger proteins and a catalytic cofactor ...
Xiaofeng Dai, Jitian Li
wiley   +1 more source

Descemet stripping only for Descemet's membrane detachment and sectoral corneal edema. [PDF]

Am J Ophthalmol Case Rep, 2023
Khan NC, Lin CC.
europepmc   +1 more source

Hippo Pathway–YAP/TAZ Signaling: Molecular Mechanisms, Biological Function, Diseases, and Therapeutic Targets

MedComm, Volume 7, Issue 10, October 2026.
The Hippo–YAP/TAZ–TEAD pathway integrates mechanical and biochemical cues to govern organ growth, regeneration, cancer, and fibrosis. This review dissects pathway physiology, TEAD structural pharmacology and ligandable pockets, and therapeutic strategies spanning palmitoylation‐pocket inhibitors, PROTAC degraders, and gene/RNA therapies, highlighting ...
Xiaodan Qu, Zhan‐you Wang
wiley   +1 more source

Multifunctional Hydrogels: Rational Design and Application in Regenerative Medicine

MedComm, Volume 7, Issue 10, October 2026.
Multifunctional hydrogels represent a paradigm shift in regenerative medicine, integrating rational material design with bioactive functionality to address complex tissue repair challenges. This review systematically examines the molecular engineering, structure–function relationships, and translational landscape of advanced hydrogel systems, spanning ...
Linyang Song, Epiphane K. Silli, Yazhen Xu, Huixia Lv, Ruoxian Song   +4 more
wiley   +1 more source

Update on innovative surgical techniques for omphalectomy in foals

Equine Veterinary Education, Volume 38, Issue 10, Page 548-555, October 2026.
Summary Umbilical infection is a common foal disorder, prone to complications, requiring surgical excision in severe cases. Timely surgical excision is the treatment of choice in these cases, as the infected umbilicus places the foal at risk for further fatal complications, such as sepsis and septic arthritis.
O. Haion, A. J. Tatz, R. Dahan, G. Kelmer   +3 more
wiley   +1 more source

Severe Corneal Edema Increases ECL From Grafts After DSAEK-Corneal Edema and ECL After DSAEK. [PDF]

Eye Contact Lens, 2022
Gu S, Peng R, Xiao G, Hong J.
europepmc   +1 more source