The Homeobox Genes: Classification, Regulation, Biological Functions, and Diseases
MedComm, Volume 7, Issue 4, April 2026.Overview of the homeobox gene superfamily and its pathophysiological roles. The homeobox superfamily comprises several major classes, including ANTP, PRD, TALE, LIM, POU, and others. Among these, the HOX clusters (A–D) play critical roles in embryonic development specifically in conferring cellular identity, regulating morphogenesis, and guiding axial ...
Maedeh Dadzadi +5 more
wiley +1 more source
An observational cross-sectional study on the corneal endothelium of medium-term rigid gas permeable contact lens wearers [PDF]
, 2017 Doughty, Michael
core +1 more source
Unraveling Chronic Pain: From Mechanisms and Risks to Diagnosis and Treatment
MedComm, Volume 7, Issue 4, April 2026.Chronic pain arises through distinct molecular pathways categorized into nociceptive, neuropathic, and nociplastic types. Nociceptive pain begins with TRP channel activation in peripheral nociceptors, signaling via Aδ‐ and C‐fibers through the spinal dorsal horn and spinothalamic tracts to the brain, regulated by descending inhibition and involving ...
Xiaofeng Dai +3 more
wiley +1 more source
Tumor‐Bearing Status Accelerates Bleomycin‐Induced Pulmonary Inflammation via Endothelial Activation
Thoracic Cancer, Volume 17, Issue 7, April 2026.In subcutaneous tumor‐bearing mice, inflammatory cell infiltration into the lung was aggravated via endothelial activation. The tumor‐bearing status additively aggravated BLM‐induced lung inflammation. Proinflammatory changes in the lungs accelerated by tumor‐bearing status might be involved in the development of drug‐induced lung inflammation ...
Shoko Isoyama +11 more
wiley +1 more source
Deep Learning-Based Automatic Diagnosis of Keratoconus with Corneal Endothelium Image. [PDF]
Ophthalmol Ther, 2023 Wan Q +5 more
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Soluble Epoxide Hydrolase Inhibitors Improve Cornea Alkali Wound Healing
The FASEB Journal, Volume 40, Issue 6, 31 March 2026.Soluble epoxide hydrolase (sEH) inhibition enhances corneal wound healing following alkali injury. (A) Schematic representation of corneal injury induced by NaOH or ammonia showing elevated sEH expression in corneal keratocytes. This leads to rapid hydrolysis of epoxy fatty acids (EpFAs), reducing their bioavailability and contributing to enhanced ...
Xiaowen Lu +10 more
wiley +1 more source
The FASEB Journal, Volume 40, Issue 5, 15 March 2026.The role of 42 amino acids long amyloid beta (Aβ) in the retinal pigment epithelium (RPE) was investigated using 5xFAD mice model overproducing Aβ. The RPE cells of 5xFAD mice showed increased oxidative stress, accumulation of autophagy‐destined proteins, increased expression of secretory autophagy markers, and increase in epithelial‐to‐mesenchymal ...
Johanna Ruuth +7 more
wiley +1 more source
The Innovative Biomaterials and Technologies for Developing Corneal Endothelium Tissue Engineering Scaffolds: A Review and Prospect. [PDF]
Bioengineering (Basel), 2023 Chi M, Yuan B, Xie Z, Hong J.
europepmc +1 more source
The soil and the seed: The relationship between Descemet's membrane and the corneal endothelium. [PDF]
Exp Eye Res, 2023 Petrela RB, Patel SP.
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Effects of chewing tobacco on corneal endothelium in patients with diabetes mellitus. [PDF]
Eye (Lond), 2023 Jha A, Verma A, Priya C.
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