Results 61 to 70 of about 444,196 (307)

A practical and safer model of nitrogen mustard injury in cornea.

PLoS ONE
PurposeSulfur mustard (SM) is an alkylating agent used in warfare and terrorism that inflicts devastating ocular injuries. Although the clinical symptoms are well described, the underlying mechanisms are not fully understood, hindering the development of
Ana M Sandoval-Castellanos, Yao Ke, Tiffany M Dam, Emanual Michael Maverakis, Mark J Mannis, Xiao-Jing Wang, Min Zhao   +6 more
doaj   +1 more source

Pattern and Outcome of Chest Injuries at Bugando Medical Centre in Northwestern Tanzania. [PDF]

, 2011
Chest injuries constitute a continuing challenge to the trauma or general surgeon practicing in developing countries. This study was conducted to outline the etiological spectrum, injury patterns and short term outcome of these injuries in our setting ...
Joseph B Mabula, Chalya, Phillipo L, Mahalu William, Lema, Monafisha K, Lema Monafisha K, Mahalu, William, Monafisha K Lema, Phillipo L Chalya, Mabula, Joseph B, Mabula Joseph B, Chalya Phillipo L, William Mahalu   +11 more
core   +2 more sources

OAF Blocks SIAH1‐Mediated Degradation of SCPX, a Therapeutic Strategy for MASLD

Advanced Science, EarlyView.
This study shows OAF directly binds to SCPX and inhibits its interaction with the E3 ligase SIAH1, thereby protecting SCPX from ubiquitin‐dependent degradation and stabilizing its levels. This OAF‐SCPX axis represents a novel pathway in lipid homeostasis, highlighting OAF as a promising therapeutic candidate for MASLD.
Zongxi Li, Jingyue Song, Kaili Ma, Shunan Tang, Shuqian Wang, Wenya Ji, Chen Lu, Ting Zhang, Huaping Zheng, Xiaowei Zheng, Shanshan Lai, Cheng Deng   +11 more
wiley   +1 more source

Histopathological injuries induced by long term exposure to green light on the eye components in (Heckel) fish Noemacheilus tigris [PDF]

Iraqi Journal of Veterinary Sciences, 2009
The present study examined histopathological injuries in the structural components of the eye of Noemacheilus tigris fish as a result of exposure, for nine continuous months to green light band at wave lengths 495-570 nm and 550 lux light intensity under
A. A. Abid and S. A. A. AL-Thanoon
doaj   +1 more source

TECTB Variants Reveal Tectorial Membrane Vulnerability in Dominant Non‐Syndromic Hearing Loss

Advanced Science, EarlyView.
TECTB is a non‐collagenous protein of the tectorial membrane – an extracellular matrix of the cochlea. This study identifies dominant missense variants in TECTB linked to human hereditary deafness in two unrelated families. Genetically engineered mice homozygous for one of the variants are profoundly deaf, whereas heterozygous mice have normal hearing ...
Evan B. Hale, Barbara Vona, Richard J. Goodyear, Richard T. Osgood, Jun Shen, Sami S. Amr, Karen Mojica, Michaela A. H. Hofrichter, Jörg Schröder, Sophie Flandin, Paul Gratias, Ricardo Vera‐Monroy, Katherine Callahan, Kerry L. Gudlewski, Rolen Quadros, Masato Ohtsuka, JoAnn McGee, Edward J. Walsh, Cynthia C. Morton, Thomas Haaf, Channabasavaiah Gurumurthy, James E. Saunders, Guy P. Richardson, Artur A. Indzhykulian   +23 more
wiley   +1 more source

A Clinical Evaluation of Outcome with regard to Corneal Injuries in Tertiary Care Hospital [PDF]

, 2021
INTRODUCTION: Blindness is a major public health problem in most developing countries. One of the most important preventable and avoidable cause of blindness is corneal injuries.
Jamuna, K
core  

TGFBI Maintains Fibrocartilage Homeostasis by Restraining O‐GlcNAcylation to Inactivate and Destabilize ADAMTS16 in Temporomandibular Joint Osteoarthritis

Advanced Science, EarlyView.
TGFBI deficiency elevates O‐GlcNAcylation, promoting the transcriptional activation of ADAMTS16 and OGT‐mediated post‐translational modification of ADAMTS16 at Ser1170. This leads to its stabilization and accumulation, driving chondrocyte metabolic disorders and senescent phenotypes, ultimately resulting in fibrocartilage dysfunction and TMJOA ...
Xin Liu, Xinyue Luo, Jie Zhao, Ziyan Jiang, Jiayi Zhai, Taomin Zhu, Xueke Jia, Xiaohan Ma, Henghua Jiang, Huimin Li, Yaping Feng, Jin Ke, Xing Long   +12 more
wiley   +1 more source

Splenic Injuries at Bugando Medical Centre in Northwestern Tanzania: A Tertiary Hospital Experience. [PDF]

, 2012
Splenic injuries constitute a continuing diagnostic and therapeutic challenge to the trauma or general surgeons practicing in developing countries where sophisticated imaging facilities are either not available or exorbitantly expensive.
Gilyoma Japhet M, Mabula D Mchembe, Giiti, Geofrey, Alphonce B Chandika, Gilyoma, Japhet M, Chandika Alphonce B, Dass Ramesh M, Chalya, Phillipo L, McHembe, Mabula D, Phillipo L Chalya, Chalya Phillipo L, Joseph B Mabula, Dass, Ramesh M, Giiti Geofrey, Mchembe Mabula D, Chandika, Alphonce B, Geofrey Giiti, Ramesh M Dass, Japhet M Gilyoma, Mabula, Joseph B, Mabula Joseph B   +20 more
core   +1 more source

SIRT7‐Mediated H2BK120 Succinylation Drives Aberrant Mitophagy in Sepsis‐Associated Cognitive Dysfunction

Advanced Science, EarlyView.
Sepsis triggers hippocampal SIRT7 loss, promoting histone H2B succinylation and activation of the PD‐1/PD‐L1–PINK1 axis. This metabolic‐epigenetic cascade drives aberrant mitophagy and neuronal injury, ultimately causing cognitive deficits. Targeting SIRT7‐dependent succinylation offers a potential strategy to protect brain function during sepsis ...
Na Meng, Jiateng Zhou, Xiaoyu Guo, Ting Hong, Xuelian Li, Xingyu Wei, Chanhua Zhang, Xixue Zhang, Songbin Liu, Yulin Zhang, Liangfang Yao, Lina Huang, Weidong Gu   +12 more
wiley   +1 more source

Congenital Unilateral Corneal Anaesthesia with Microphthalmos: A Case Report

Case Reports in Ophthalmological Medicine, 2012
Congenital corneal anaesthesia (CCA) is an uncommon condition difficult to diagnose. We report the case of a 20-month-old boy who presented with unilateral congenital corneal anaesthesia. The child was referred with a persistent corneal epithelial defect,
George Voyatzis, Achyut Mukherjee, Madhavan S. Rajan, Louise E. Allen   +3 more
doaj   +1 more source