Results 41 to 50 of about 17,651 (258)

A Proof‐of‐Concept Assessment of a Novel Wearable Eyelid Muscle Device: A Pre‐Clinical Animal Cadaver Study for Eyelid Closure Restoration

Advanced Robotics Research, EarlyView.
This article introduces a soft wearable eyelid sling device incorporating a hydraulic soft artificial muscle (SAM) for achieving complete closure of an eyelid. The SAM is driven by a cam mechanism that provides a displacement profile closely matched with those of a healthy eyelid.
Patrick Pruscino, Phuoc Thien Phan, James Davies, Bibhu Sharma, Tianruo Guo, Chi Cong Nguyen, Nigel H. Lovell, Thanh Nho Do   +7 more
wiley   +1 more source

LNP-encapsulated miRNA29b for corneal repair: A novel approach to combat fibrosis

Materials Today Bio
Severe corneal injuries often result in corneal scarring, leading to visual impairment and corneal blindness. Currently, there is a lack of effective anti-corneal fibrosis drugs in clinical practice. MicroRNA-based therapies hold significant potential in
Dongyan Li, Jing Ji, Xinyue Li, Yi Xie, Yan Huang, Junzhi Qin, Xili Ding, Lizhen Wang, Yubo Fan   +8 more
doaj   +1 more source

Corneal Response to Injury and Infection in the Horse

Veterinary Clinics of North America: Equine Practice, 2017
This article describes the natural responses of the immune system and the cornea to injury and infection. The process of reepithelialization and reformation of stromal collagen is discussed, as are the clinical signs and manifestations of the effects of the healing response when it is routine and when it is pathologic.
Department of Surgical and Radiological Sciences, University of California, Davis, One Shields Avenue, Davis, CA, USA ( host institution ), Plummer, Caryn E. ( UF author )   +1 more
openaire   +3 more sources

A Whole‐Head Finite Element Model for Electrical Neuromodulation via Visual Brain‐Machine Interfaces

Advanced Science, EarlyView.
A multimodal, personalized head model is presented that integrates the entire visual pathway with surrounding tissues to simulate electrical stimulation of the optic nerve. In vivo validation in humans and goats, plus systematic component‐elimination analysis, demonstrates the high accuracy of the comprehensive model.
Shengjian Lu, Tonghe Yang, Yuan Geng, Huan Wu, Yangrui Huang, Te Zheng, Haodi Chen, Shurui Huang, Yi Cao, Jian Yang, Wentao Yan, Yikui Zhang, Wencan Wu   +12 more
wiley   +1 more source

Neutrophil pyroptosis regulates corneal wound healing and post‐injury neovascularisation

Clinical and Translational Medicine
Rationale The cornea is a unique structure that maintains its clarity by remaining avascular. Corneal injuries can lead to neovascularisation (CNV) and fibrosis and are the third most common cause of blindness worldwide. Objective Corneal injuries induce
Peng Chen, Zhentao Zhang, Lilian Sakai, Yanping Xu, Shanzhi Wang, Kyung Eun Lee, Bingchuan Geng, Jongsoo Kim, Bao Zhao, Qiang Wang, Haitao Wen, Heather L. Chandler, Hua Zhu   +12 more
doaj   +1 more source

Determining the effect of ocular chemical injuries on topical drug delivery

Drug Delivery, 2021
Ocular chemical injuries (OCIs) commonly cause ocular damage and visual loss and treatment uses topical therapies to facilitate healing and limit complications.
Ghazala Begum, Thomas Leigh, David Stanley, Ann Logan, Richard James Blanch   +4 more
doaj   +1 more source

Serp-1 Promotes Corneal Wound Healing by Facilitating Re-epithelialization and Inhibiting Fibrosis and Angiogenesis

Frontiers in Cardiovascular Medicine, 2021
Purpose: Chemical corneal injuries carry a high morbidity and commonly lead to visual impairment. Here, we investigate the role of Serp-1, a serine protease inhibitor, in corneal wound healing.Methods: An alkaline-induced corneal injury was induced in 14
Brent Ju, Owen Guo, Dathe Z. Benissan-Messan, McKinley H. Shawver, Peng Chen, Bingchuan Geng, Siqi Wei, Jordan R. Yaron, Alexandra R. Lucas, Hua Zhu   +9 more
doaj   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

The role of lymphatic vessels in corneal fluid homeostasis and wound healing

Journal of Ophthalmic Inflammation and Infection
The cornea, essential for vision, is normally avascular, transparent, and immune-privileged. However, injuries or infections can break this privilege, allowing blood and lymphatic vessels to invade, potentially impairing vision and causing immune ...
Karina Hadrian, Claus Cursiefen
doaj   +1 more source

Chiral Nanoparticles Suppress Inflammatory Infiltration to Promote Extracellular Matrix Remodeling for Ectopia Lentis Therapy

Advanced Science, EarlyView.
L‐cysteine‐configured chiral polyurethane nanoparticles suppress ocular inflammation and reduce extracellular matrix (ECM) degradation in ectopia lentis by regulating macrophages polarization and inhibiting nuclear factor kappa B signaling pathway. By promoting zonular fiber‐associated protein restoration and tissue repair, this minimally invasive ...
Yinuo Wen, Yan Yang, Haihan Gao, Yan Liu, Xinyue Wang, Linghao Song, Ruohong Li, Ao Miao, Jie Xu, Zhennan Zhao, Dan Li, Shenjie Peng, Linzhao Li, Min Zhang, Yonghang Liu, Liren Wang, Tianhui Chen, Yongxiang Jiang   +17 more
wiley   +1 more source