Results 51 to 60 of about 144,592 (220)

The higher-order aberrations (HOAs) based on corneal opacity grading in corneal dystrophies.

, 2016
There were no significant differences in HOAs among corneal opacity grade 1, 2 and 3 in GCD2 (all Ps > 0.05). In the MCD group, the HOAs in eyes with corneal opacity grade 3 were significantly larger than those of grade 2 (P = 0.018).
Yumi Okuyama (3044502), Yukari Yagi-Yaguchi (3044496), Takefumi Yamaguchi (345080), Yoshiyuki Satake (3044499), Jun Shimazaki (600554), Kazuo Tsubota (247512)   +5 more
core   +1 more source

Surgery versus epilation for the treatment of minor trichiasis in Ethiopia: a randomised controlled noninferiority trial. [PDF]

, 2011
Trachomatous trichiasis can cause corneal damage and visual impairment. WHO recommends surgery for all cases. However, in many regions surgical provision is inadequate and patients frequently decline.
Saul N. Rajak, Habtamu, E, Amir Bedri Kello, Helen A Weiss, Emerson Paul M., Peng T. Khaw, Weiss Helen A., Rajak, SN, Gebre Teshome, Burton Matthew J., Helen A. Weiss, Gebre, Teshome, Robin L Bailey, Paul M Emerson, Matthew J. Burton, Gilbert, CE, Clare E Gilbert, Matthew J Burton, Khaw Peng T., Rajak Saul N., Habtamu Esmael, Saul N Rajak, David C. W. Mabey, Emerson, PM, Weiss, Helen A, Kello, AB, Genet, A, Khaw, PT, Genet Asrat, Bailey Robin L., Gebre, T, Bailey, RL, Gilbert Clare E., David C W Mabey, Clare E. Gilbert, Rajak, Saul N, Habtamu, Esmael, Kello Amir Bedri, Teshome Gebre, Weiss, HA, Peng T Khaw, Burton, Matthew J, Esmael Habtamu, Mabey David C. W., Genet, Asrat, Kello, Amir Bedri, Gilbert, Clare E, Emerson, Paul M, Bailey, Robin L, Khaw, Peng T, Asrat Genet, Mabey, DC, Paul M. Emerson, Mabey, David CW, Burton, MJ, Robin L. Bailey   +55 more
core   +1 more source

Unilateral buphthalmos, corneal staphyloma and corneal fistula caused by pathogenic variant in the PITX3 gene: a case report

BMC Ophthalmology, 2022
Introduction PITX3 has been reported to be associated with congenital cataracts, anterior segment mesenchymal dysgenesis, Peters’ anomaly, and microphthalmia.
Lin Zhou, Zhike Xu, Qianying Wu, Xin Wei
doaj   +1 more source

A Rare De Novo Missense Mutation in IFT122 Confers a Genetic Susceptibility Factor of Idiopathic Pediatric Uveitis Via Trio‐based Whole‐Exome Sequencing

Advanced Science, EarlyView.
A rare de novo IFT122‐A773E variant is identified in idiopathic pediatric uveitis and shown to exacerbate retinal inflammation and barrier dysfunction. Mechanistically, the variant enhances IFT43 interaction, elevates calcium signaling, and activates the MEK/ERK/FRA1 axis, revealing a previously unrecognized cilia‐associated pathway that may increase ...
Qian Zhou, Jiaxing Huang, Yilin Wang, Xingran Li, Xianyang Liu, Lingyu Dai, Hongshun Li, Qingfeng Wang, Jiangyi Liu, Guannan Su, Wanyun Zhang, Yang Deng, Qingfeng Cao, Yujie Lai, Xiang Luo, Changwei Huang, Ling Chen, Shengping Hou, Peizeng Yang   +18 more
wiley   +1 more source

ROS‐Responsive Eye Drop for Controlled Release of 20‐Deoxyingenol Improves Diabetic Corneal Healing by Activating Macrophage Autophagy and Metabolic Reprogramming

Advanced Science, EarlyView.
Schematic illustration of ROS‐responsive TSPBA‐PVA microspheres loaded with 20‐deoxyingenol (TP/20‐DOI) for diabetic corneal wound healing: (a) fabrication and ROS‐triggered release; (b) autophagy activation and metabolic reprogramming in macrophages; (c) suppression of macrophage‐derived CXCL3/CXCL5, attenuation of neutrophil infiltration, and ...
Jiaxin Wu, Wanying Chen, Haijiang Qiu, Weihan Zheng, Ying Jiao, Jingheng Du, Zhudan Zhuang, Xing Hua, Jingyi Gu, Yuheng Liu, Zhaojin Li, Jingbin Xie, Hanxiao Sun, Huifei Lan, Xin Sun, Yunxia Xue, Ting Fu, Zhijie Li, Guobing Chen, Shiyu Li, Jun Liu   +20 more
wiley   +1 more source

Evaluating anterior corneal surface using Placido ring mires for irregular astigmatism in refractory corneal subepithelial infiltrates after adenoviral conjunctivitis

BMC Ophthalmology
Background Corneal subepithelial infiltrates (SEIs) are characteristic clinical findings of adenoviral keratoconjunctivitis (AKC). In eyes with SEIs, both corneal opacity and irregular astigmatism may interfere with vision. However, irregular astigmatism
Noriko Toyokawa, Kaoru Araki-Sasaki, Hideya Kimura, Shinichiro Kuroda   +3 more
doaj   +1 more source

FUT1 deficiency elicits immune dysregulation and corneal opacity in steady state and under stress. [PDF]

Cell Death Dis, 2020
Fucosylation is a biological process that plays a critical role in multiple cellular functions from cell adhesion to immune regulation. Fucosyltransferases (FUTs) mediate fucosylation, and dysregulation of genes encoding FUTs is associated with various ...
Kim KW, Ryu JS, Ko JH, Kim JY, Kim HJ, Lee HJ, Oh JH, Chung JH, Oh JY.   +8 more
europepmc   +2 more sources

MRSA‐Triggered Disassembly of an Immune‐Recruiting NIR Probe for Bacterial Imaging and Clearance

Advanced Science, EarlyView.
A bacteria–immune cell‐bridging supramolecular amphiphile, Dman‐C11, undergoes MRSA membrane‐triggered disassembly to activate NIR fluorescence and photodynamic killing, inducing ferroptosis‐like bacterial death and immune‐assisted clearance in wound infection and keratitis models.
Jiacheng Du, Yongyi Chen, Ling Lei, Yunzhe Tao, Yu Peng, Qingyang Zhang, Qinghua Wang, Hai‐Yu Hu   +7 more
wiley   +1 more source

Differential Diagnosis of Mucopolysaccharidoses Types I, II, III, IVA, and VI Through Analysis of Leukocytic Inclusions

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Mucopolysaccharidoses (MPS) are lysosomal storage disorders characterized by the accumulation of glycosaminoglycans (GAGs), which can lead to cytoplasmic alterations in leukocytes. The objective of this study was to characterize leukocyte inclusions in patients with different types of MPS and assess their diagnostic relevance.
Márcio A. W. Melo, Marcelo S. Kertenetzky, Cristina M. Silveira, Maíra M. Ribeiro, Paula F. Medeiros, Gabriela S. Arcanjo   +5 more
wiley   +1 more source

Biallelic PAX6 Variants in an Adult With Severe Microphthalmia and Preserved Intellectual Function

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT PAX6 encodes a dosage‐sensitive transcription factor that is essential for eye development. Heterozygous PAX6 disease is well characterized, but biallelic disease is extremely rare and has been associated with anophthalmia, severe brain malformations, and perinatal lethality.
Karl De Geer, Britt‐Marie Anderlid, Lena Jacobson, Daniel Martín Muñoz, Erik Björck   +4 more
wiley   +1 more source