High-risk Corneal Transplantation: Recent Developments and Future Possibilities
Transplantation, 2019 Human corneal transplantation (keratoplasty) is typically considered to have superior short- and long-term outcomes and lower requirement for immunosuppression compared to solid organ transplants because of the inherent immune privilege and tolerogenic ...
W. Armitage +10 more
semanticscholar +1 more source
Poly-l/dl-lactic acid films functionalized with collagen IV as carrier substrata for corneal epithelial stem cells [PDF]
, 2019 Limbal epithelial stem cells (LESCs) are responsible for the renewal of corneal epithelium. Cultivated limbal epithelial transplantation is the current treatment of choice for restoring the loss or dysfunction of LESCs.
Calonge Cano, Margarita +7 more
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Potential benefits and risks of clinical xenotransplantation [PDF]
, 2012 The transplantation of organs and cells from pigs into humans could overcome the critical and continuing problem of the lack of availability of deceased human organs and cells for clinical transplantation.
Ayares, D, Cooper, DKC
core +2 more sources
Journal of Functional Biomaterials, 2015 Corneal endothelium is a single layer of specialized cells that lines the posterior surface of cornea and maintains corneal hydration and corneal transparency essential for vision.
Jesintha Navaratnam +3 more
doaj +1 more source
Cell therapy of congenital corneal diseases with umbilical mesenchymal stem cells: lumican null mice. [PDF]
PLoS ONE, 2010 Keratoplasty is the most effective treatment for corneal blindness, but suboptimal medical conditions and lack of qualified medical personnel and donated cornea often prevent the performance of corneal transplantation in developing countries.
Hongshan Liu +7 more
doaj +1 more source
Corneal transplantation in the modern era
The Indian journal of medical research, 2019 Corneal blindness is one of the major causes of reversible blindness, which can be managed with transplantation of a healthy donor cornea. It is the most successful organ transplantation in the human body as cornea is devoid of vasculature, minimizing ...
Rashmi Singh +3 more
semanticscholar +1 more source
Long-Term Results after DMEK (Descemet’s Membrane Endothelial Keratoplasty) [PDF]
, 2020 Ziel der Arbeit: Evaluation der langfristigen Ergebnisse sowie der Komplikationsrate nach Descemet’s Membran Endothelialen Keratoplastik (DMEK) Methoden: Eine cross-sectional, Fall-Serien Studie.
Wardeh, Rima
core +1 more source
Journal of Ophthalmology, 2019 Background. For so long, corneal diseases have been known as one of the leading causes to blindness in the global. This blindness might be due to failure to accept the corneal transplantation.
Yordanos Tsehai Jemberu +4 more
doaj +1 more source
Preliminary studies of constructing a tissue-engineered lamellar corneal graft by culturing mesenchymal stem cells onto decellularized corneal matrix [PDF]
International Journal of Ophthalmology, 2021 AIM: To construct a competent corneal lamellar substitute in order to alleviate the shortage of human corneal donor. METHODS: Rabbit mesenchymal stem cells (MSCs) were isolated from bone marrow and identified by flow cytometric, osteogenic and adipogenic
Yu-Jie Cen +3 more
doaj +1 more source
Minocycline is cytoprotective in human corneal endothelial cells and induces anti-apoptotic B-cell CLL/lymphoma 2 (Bcl-2) and X-linked inhibitor of apoptosis (XIAP) [PDF]
, 2010 Introduction Loss of corneal endothelial cells (CECs) is one major factor limiting transplant clarity and survival after keratoplasty. Amongst other factors, apoptosis due to cellular stress is responsible for these problems.
Hirneiß, Christoph +3 more
core +3 more sources