Results 111 to 120 of about 5,756,266 (314)

SR‐A3 Promotes USP18‐Mediated deISGylation of STING to Protect Against Myocardial Ischemia‐Reperfusion Injury

Advanced Science, EarlyView.
MI/RI is a major clinical challenge with high morbidity and mortality. This study demonstrates that SR‐A3 expression is downregulated in MI/RI, and its deletion exacerbates damage via the USP18/ISG15/STING axis, revealing SR‐A3 as a potential therapeutic target.
Yufei Han, Guolin Miao, Yinqi Zhao, Zhiyong Du, Kaikai Lu, Changqi Xiao, Aiden Xian, Jiaxin Duanmu, Zihao Zhou, Jinxuan Chen, Lianxin Zhang, Chao Zhai, Yitong Xu, Zhaoling Li, Xianqin Shen, Sijing Shi, Jingxuan Chen, Si Mei, Yuan Fang, Liwen Zheng, Ling Zhang, Yuhui Wang, Wei Huang, Erdan Dong, Xunde Xian   +24 more
wiley   +1 more source

Prognostic Value of the Systemic Inflammatory Response Index in Patients with Acute Coronary Syndrome and Obstructive Sleep Apnea

Journal of Inflammation Research
Qian He,1,2 Yun Zhou,1 Xueying Tong,3 Lei Zhen,1 Shutian Shi,1 Wei Gong,1,4 Shaoping Nie1 1Center for Coronary Artery Disease, Division of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, People’s Republic of China ...
He Q, Zhou Y, Tong X, Zhen L, Shi S, Gong W, Nie S   +6 more
doaj  

High prevalence of metabolic syndrome among young women with premature coronary artery disease

, 2005
Background The metabolic syndrome is more prevalent with the use of the recently defined National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III) criteria and is associated with a greater risk of atherosclerotic cardiovascular ...
Turhan, H, Basar, N, Yasar, AS, Bicer, A, Erbay, AR, Yetkin, E   +5 more
core   +1 more source

Phase Separation of TRIM21 Modulates PTPN14 Stability to Drive Flow‐Dependent Endothelial Activation and Atherogenesis

Advanced Science, EarlyView.
Disturbed flow promotes the formation of TRIM21‐rich biomolecular droplets, which concentrate TRIM21 and PTPN14 and facilitate their SPRY‐FERM interaction (illustrated by the TRIM21 D355‐PTPN14 R132 salt bridge). This condensate‐driven proximity enables TRIM21 to catalyze K48‐linked polyubiquitination of PTPN14 at lysine 956, leading to proteasome ...
Xue He, Qiannan Ma, Xue Wang, Jiaxu Mang, Chufeng Li, Bingjun Wu, Liu Yao, Yequn Chen, Qiankun Bao, Yi Zhu, Jinlong He   +10 more
wiley   +1 more source

Preventive percutaneous coronary intervention versus optimal medical therapy for vulnerable plaque: a meta-analysis

BMC Cardiovascular Disorders
Background The effectiveness and safety of preventive percutaneous coronary intervention (PCI) on non-flow limiting vulnerable coronary plaque remain uncertain.
Yating Chen, Xiaochen Liu, Yuyao Qiu, Qian Guo, Feiyu Zhang, Shaoping Nie, Hongtao Liu, Deyong Long, Xiao Wang   +8 more
doaj   +1 more source

Study protocol for low-dose evaluation of aspirin in patients with ST-elevation myocardial infarction undergoing percutaneous coronary intervention (LEAST): a multicenter, double-blind, randomized controlled clinical trial

Annals of Medicine
Background Dual antiplatelet therapy (DAPT) with aspirin and ticagrelor is standard treatment for ST-elevation myocardial infarction (STEMI). While the optimal ticagrelor dose is established, the ideal aspirin maintenance dose remains debatable ...
Wen Zheng, Zhao-Ting Gong, Hai-Yan Qian
doaj   +1 more source

Coronary artery grafting in infants [PDF]

, 2009
Coronary artery bypass grafting (CABG) with cardiac vale repair is an uncommon surgery in infants. CABG is technically demanding in infants due to the small size not only of the coronary arteries but also the potential graft arteries.
Menon, Rajgopal, Zacharias, S., Maskari, Salim, Valliathu, J.   +3 more
core  

Serial Molecular‐Microstructural Multimodal Intravascular Imaging of Atherosclerotic Plaques in Mice

Advanced Science, EarlyView.
A novel longitudinal molecular and microstructural intravascular imaging approach is developed to study murine atherosclerosis. The technique combines a unique surgical model with a miniaturized multimodal device to detect macrophage activity and lipid simultaneously.
Jiawen Li, Joanne T. M. Tan, Lei Xiang, Jiandi Liu, Ayla Hoogendoorn, Victoria A. Nankivell, Lauren Sandeman, Richard Le, Rouyan Chen, Robert A. McLaughlin, Peter J. Psaltis, Johan W. Verjans, Christina A. Bursill   +12 more
wiley   +1 more source

Association of Weight Change Across Adulthood with Obstructive Sleep Apnea: The Multi-Ethnic Study of Atherosclerosis

Nature and Science of Sleep
Jiaqi Du,1 Wenlong Zhao,1 Yixiang Liu,1 Siyi Li,1 Zekun Zhang,1 Yun Zhou,1 Wenrui Sun,1 Hui Ai,1 Shaoping Nie,1 Wei Gong2 1Center for Coronary Artery Disease, Division of Cardiology, Beijing Anzhen Hospital, Capital Medical University, National Clinical ...
Du J, Zhao W, Liu Y, Li S, Zhang Z, Zhou Y, Sun W, Ai H, Nie S, Gong W   +9 more
doaj  

THSD7A Exacerbates Atherosclerosis via Activation of Signaling Axis αvβ3/CEBPD/IL1A

Advanced Science, EarlyView.
THSD7A exerts pro‐inflammatory effects and exacerbates atherosclerosis. Mechanistically, THSD7A regulates endothelial cell inflammation and atherosclerosis by activating the αvβ3/CEBPD/IL1A signaling axis. THSD7A is not only a genetic marker but also a potential therapeutic target for coronary artery disease (CAD).
Jiankun Liu, Hongfei Liu, Yiqi Wan, Andong Wu, Jiayu Qiu, Xueting Gong, Ya Zhao, Yuanyuan Li, Bingbing Zhou, Yangyi Zheng, Fang Wu, Yuanzheng Zhu, Weixin Lv, Xueer Li, Qiang Yuan, Xiao‐Li Tian   +15 more
wiley   +1 more source