Results 151 to 160 of about 1,108,368 (374)

The glycolytic enzyme PKM2 bridges metabolic and inflammatory dysfunction in coronary artery disease

Journal of Experimental Medicine, 2016
Shirai et al. show that the glycolytic enzyme PKM2 serves as a molecular integrator of metabolic dysfunction, oxidative stress and tissue inflammation in macrophages from patients with atherosclerotic coronary artery disease.
T. Shirai, R. Nazarewicz, Barbara B. Wallis, R. Yanes, R. Watanabe, M. Hilhorst, L. Tian, D. Harrison, J. Giacomini, T. Assimes, J. Goronzy, C. Weyand   +11 more
semanticscholar   +1 more source

MMP9High Neutrophils are Critical Mediators of Neutrophil Extracellular Traps Formation and Myocardial Ischemia/Reperfusion Injury

Advanced Science, EarlyView.
During a heart attack, neutrophils rapidly activate and differentiate into a specific subset characterized by high levels of MMP9, a tissue‐damaging enzyme, via the SPI1/CST7 pathway. These neutrophils form harmful net‐like structures (Neutrophil extracellular traps, NETs) that exacerbate heart injury.
Shiyu Hu, Feng Zhang, Jingpu Wang, Jian Zhang, Chenguang Li, Yang Lyu, Yiwen Wang, Rong Huang, Yang Gao, Hongbo Yang, Juying Qian, Wenwen Tang, Jiatian Cao, Junbo Ge   +13 more
wiley   +1 more source

Inactivating Variants in ANGPTL4 and Risk of Coronary Artery Disease.

New England Journal of Medicine, 2016
BACKGROUND Higher-than-normal levels of circulating triglycerides are a risk factor for ischemic cardiovascular disease. Activation of lipoprotein lipase, an enzyme that is inhibited by angiopoietin-like 4 (ANGPTL4), has been shown to reduce levels of ...
F. Dewey, V. Gusarova, C. O’Dushlaine, O. Gottesman, Jesus Trejos, Charleen Hunt, C. V. van Hout, L. Habegger, D. Buckler, Ka-man V Lai, J. Leader, M. Murray, M. Ritchie, H. Kirchner, David H. Ledbetter, John Penn, Alexander E. Lopez, I. Borecki, J. Overton, J. Reid, D. Carey, A. Murphy, G. Yancopoulos, A. Baras, J. Gromada, A. Shuldiner   +25 more
semanticscholar   +1 more source

Host Plasma Microenvironment in Immunometabolically Impaired HIV Infection Leads to Dysregulated Monocyte Function and Synaptic Transmission Ex Vivo

Advanced Science, EarlyView.
Network‐based risk stratification of people living with HIV (PWH) on prolonged therapy using multi‐omics data identifies 44% of the patients are at risk of immunometabolic complications. A senescence‐associated myeloid cell‐driven plasma microenvironment drives immunometabolic dysregulation in at‐risk PWH.
Flora Mikaeloff, Marco Gelpi, Alejandra Escós, Tianqi Wang, Soham Gupta, Anna Olofsson, Sara Svensson Akusjärvi, Sabrina Schuster, Prajakta Naval, Vikas Sood, Negin Nikouyan, Andreas D. Knudsen, Beate Vestad, Julie Høgh, Johannes R. Hov, Thomas Benfield, Marius Trøseid, Vinay Pawar, Marijana Rucevic, Rui Benfeitas, Ákos Végvári, Liam O'Mahony, Rajkumar Savai, Niklas K. Björkström, Magda Lourda, João Pedro de Magalhães, Siegfried Weiss, Adil Mardinoglu, Mukesh Kumar Varshney, Annika C. Karlsson, Yasir Ahmed Syed, Susanne D. Nielsen, Ujjwal Neogi   +32 more
wiley   +1 more source

Successful Percutaneous Coronary Intervention for Acute Coronary Syndrome in a Patient With Severe Hemophilia A [PDF]

, 2010
Patients with hemophilia generally have a reduced frequency of coronary artery disease compared to the general population. As advances in the management of hemophilia have increased their life expectancy, the prevalence of coronary artery disease also ...
Arora, Bond, Bovenzi, Brener, Dae-Kyung Kim, Dong-Kie Kim, Dong-Soo Kim, Doo-Il Kim, Eun-Ji Lee, Ferrario, Girolami, Hwan-Jin Cho, Krolick, MacKinlay, Mo-Se Kim, Park, Plug, Rosendaal, Sang-Hoon Seol, Srámek, Srámek, Tae-Hyun Yang, Ung Kim, Yang Chun Han, Young-Bok Kim   +24 more
core   +2 more sources

Ischemia and No Obstructive Coronary Artery Disease (INOCA): Developing Evidence-Based Therapies and Research Agenda for the Next Decade

Circulation, 2017
The Cardiovascular Disease in Women Committee of the American College of Cardiology, in conjunction with interested parties (from the National Heart, Lung, and Blood Institute, American Heart Association, and European Society of Cardiology), convened a ...
N. Merz, C. Pepine, M. Walsh, J. Fleg
semanticscholar   +1 more source

Flavonifractor Plautii or Its Metabolite Desaminotyrosine as Prophylactic Agents for Alleviating Myocardial Ischemia/Reperfusion Injury

Advanced Science, EarlyView.
The gut microbiome is a potential target for treating cardiovascular disease. It is found that prophylactic administration of Flavonifractor plautii or its metabolite desaminotyrosine (DAT) exerts pleiotropic cardioprotective effects via promoting cardiomyocyte survival and attenuating cardiac inflammation against myocardial ischemia/reperfusion (I/R ...
Heng Du, Xu Liu, Jianghua Shen, Hailong Yuan, Hao Zhang, Gan Xi, Yujing Li, Yuhan Wang, Jiahe Zhang, Chaofan Yang, Pengfei Xu, Jiawan Wang, Fang Wang, Siqi Liu, Yanan Zhou, Qi Gu, Jingjing Lu, Tuo Wei, Zeyu Gao, Jingyi Zang, Jun Wang, Moshi Song   +21 more
wiley   +1 more source

An Effect of Spatial Filtering in Visualization of Coronary Arteries Imaging [PDF]

International Journal of Computer Science & Information Technology (IJCSIT), Vol. 2, No. 1, 2009, PP: 35-40, 2011
At present, coronary angiography is the well known standard for the diagnosis of coronary artery disease. Conventional coronary angiography is an invasive procedure with a small, yet inherent risk of myocardial infarction, stroke, potential arrhythmias, and death.
arxiv  

Spontaneous Dissection of Right Coronary Artery Manifested with Acute Myocardial Infarction [PDF]

, 2010
Spontaneous coronary artery dissection is a rare cause of acute ischemic coronary events and sudden cardiac death. It usually occurs in young women without traditional risk factors for coronary artery disease during pregnancy or postpartum period ...
Antonios Ziakas, Appleby CE, Azzarelli S, Celik SK, Cheung S, De Maio SJ Jr, Efstratios K Theofilogiannakos, Fotis Economou, Hayes CR, Ioannis H Styliadis, Jorgensen MB, Lerakis S, Lilian Mantziari, Maeder M, Maeder M, Maehara A, Manghat NE, Mortensen KH, Motreff P, Stavros Hadjimiltiades, Stelios Paraskevaidis, Unal M, Yiannis S Chatzizisis   +22 more
core   +2 more sources

The Updated NICE Guidelines: Cardiac CT as the First-Line Test for Coronary Artery Disease

Current Cardiovascular Imaging Reports, 2017
Purpose of ReviewCost-effective care pathways are integral to delivering sustainable healthcare programmes. Due to the overestimation of coronary artery disease using traditional risk tables, non-invasive testing has been utilised to improve risk ...
A. Moss, M. Williams, D. Newby, E. Nicol
semanticscholar   +1 more source