Results 211 to 220 of about 5,531,000 (262)

Current status and future perspectives of platelet function‐guided precision antiplatelet therapy for patients with cerebral infarction

Neuroprotection, EarlyView.
Antiplatelet agents target the cyclooxygenase‐1 (COX‐1)/thromboxane A2 (TXA2) and adenosine diphosphate (ADP)‐P2Y12 (cytochrome P450 2C19 [CYP2C19]‐metabolized) platelet activation pathways, resulting in either drug resistance or over‐inhibition. The individualized therapeutic window balances ischemic risk (triggered by high on‐treatment platelet ...
Guoliang Zhu, Xiaoling Chen, Xinyi Huang, Quandan Tan, Qing Cao, Yali Yang, Yapeng Lin, Jie Yang   +7 more
wiley   +1 more source

Apigenin Protects Hypertensive Intracerebral Hemorrhage by Regulating Trx1 Through Binding to PRDX2

Phytotherapy Research, EarlyView.
ABSTRACT Intracerebral hemorrhage (ICH) remains the most severe stroke subtype with high mortality and disability rates. Although apigenin has shown cerebroprotective potential in preclinical studies, its mechanism of action, particularly in hypertensive ICH, remains poorly understood.
Hao‐chen Xu, Ming Liu, Ying‐ying Sun, Jie‐Dan Ping, Qing‐hua Cui, Jing‐zhou Chen, Hao Li   +6 more
wiley   +1 more source

Plant‐Derived Natural Product Nanodelivery System in Cancer Therapy

Phytotherapy Research, EarlyView.
This review comprehensively summarizes the recent progress and emerging concepts in nanotechnology‐based delivery systems for plant‐derived natural products, with a particular focus on their application in precision cancer therapy. ABSTRACT Plant‐derived natural products have emerged as important sources of anticancer agents because of their diverse ...
Changqi Shi, LuLu Zhang, Lan Yan, Qi Geng, Li Li, Xiaojuan He, Ning Zhao, Yong Tan, Xiaomeng Zhang, Cheng Lu   +9 more
wiley   +1 more source

Nonthermal plasma approaches for combating implant‐associated infections: A compendious review

VIEW, EarlyView.
Implant‐associated infections pose serious clinical challenges. Non‐thermal plasma (NTP) modifications overcome this bottleneck in distinct ways relative to traditional sterilization methods. Gas‐phase plasmas generate highly energetic species, UV radiation and reactive oxygen/nitrogen species (RONS), which alter the implant surface properties.
A. M. Trimukhe, Satish Rojekar, Amol Gholap, K. Navaneetha Pandiyaraj, Mukesh Patekar, Claudia Riccardi, R. R. Deshmukh, Tomáš Kovářík, Kalim Deshmukh   +8 more
wiley   +1 more source

Diffusely impaired myocardial perfusion in patients with suspected coronary artery disease: Clinical utility of relative perfusion. [PDF]

Clin Physiol Funct Imaging
Vartiainen N, Rissanen AE, Hartikainen S, Halttunen S, Leikas AJ, Kariniemi E, Strengell E, Kuikka PI, Hartikainen JEK, Laitinen TP.   +9 more
europepmc   +1 more source

Indications and Efficacy of Progestogen‐Monotherapy as Menopause Hormone Therapy: A Narrative Review

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT Menopausal hormone therapy (MHT) remains the most effective treatment for vasomotor symptoms (VMS) and other manifestations of menopause; however, its use is limited in women with contraindications to oestrogen. Progestogen monotherapy, though historically underutilized, represents a viable alternative in this population. This narrative review
Chloe Thomas, Olivia Carere, Lauren Clarfield, Michelle Jacobson   +3 more
wiley   +1 more source

Comparative diagnostic performance of coronary CT angiography and invasive coronary angiography in patients with suspected coronary artery disease. [PDF]

BMC Med Imaging
Farzollahzadeh A, Shahsavari MJ, Mashoufi M, Bagali FM, Refahi S.   +4 more
europepmc   +1 more source

Renal oxygenation, function and histopathology in an ovine model of heart failure undergoing cardiopulmonary bypass with 48 hours of recovery: a prospective, observational study*

Anaesthesia, EarlyView.
Summary Introduction Acute kidney injury is common after cardiac surgery requiring cardiopulmonary bypass, yet preventive strategies are limited. Progress has been hindered by a lack of clinically relevant experimental models incorporating pre‐existing heart disease.
Anton L. Trask‐Marino, Bruno Marino, Taku Furukawa, Lachlan F. Miles, Jai Raman, Andrew D. Cochrane, Peter R. McCall, Terase F. Lancefield, Roger G. Evans, Ian E. Birchall, Alemayehu H. Jufar, Ashenafi Betrie, Lars I.P. Snel, Munenori Kusunoki, Sally G. Hood, Linda Cornthwaite, Bruce Treagus, Connie Pei Chen Ow, Lindsea C. Booth, Clive N. May, Yugeesh R. Lankadeva   +20 more
wiley   +1 more source

Age-Dependent Efficacy of Incidental Coronary Artery Calcium on Pre-CAG Chest CT: Potentially Missed Prevention Opportunities in Chinese Population. [PDF]

J Cardiovasc Dev Dis
Zhou S, Guo Y, Wang L, Wang C, Jin Z.
europepmc   +1 more source

Cross‐Sectional Study of the PREValence of Erectile DysfunctIon in the Arteriopathic Population (PREVEDI)

Andrology, EarlyView.
ABSTRACT Background Although the association between erectile dysfunction (ED) and cardiovascular disease is well established, its prevalence in patients with atherosclerosis remains poorly defined. Objectives To evaluate ED prevalence, severity, and associated risk factors (RFs) in patients with atherosclerotic disease.
Luca Farchioni, Andrea Ferri, Nicola Leone, Mattia Migliari, Luigi Alberto Maria Bartolotti, Daniele Santi, Giorgia Spaggiari, Roberto Silingardi, Stefano Gennai   +8 more
wiley   +1 more source