Results 61 to 70 of about 5,531,000 (262)

Salvianolic Acid a Disrupts the HSP90α‐AKT‐PERK Ternary Complex to Alleviate Atherosclerosis by Activating Endoplasmic Reticulum Stress of Senescent Vascular Smooth Muscle Cells

Advanced Science, EarlyView.
Salvianolic acid A (SAA) selectively induces senescent vascular smooth muscle cell apoptosis, alleviating atherosclerosis. Mechanistically, SAA targets heat shock protein 90 alpha (HSP90α) to disrupt the protein inase B (AKT)‐PRKR‐Like Endoplasmic Reticulum Kinase (PERK) scaffold, driving ubiquitin‐proteasome‐dependent AKT degradation.
Xiuya Guan, Mengkai Lu, Xinhai Cui, Dawei Zhang, Lei Zhang, Lin Lin, Yuan Li, Yuanlong Hu, Chao Li   +8 more
wiley   +1 more source

Left Ventricular Longitudinal Strain Detects Ischemic Dysfunction at Rest, Reflecting Significant Coronary Artery Disease

Diagnostics
Background/Objectives: The role of speckle-tracking echocardiography in the diagnosis of stable coronary artery disease (CAD) remains controversial.
George Koulaouzidis, Panagiota Kleitsioti, Maria Kalaitzoglou, Christos Tzimos, Dafni Charisopoulou, Panagiotis Theodorou, Ioannis Bostanitis, Adam Tsaousidis, Vasileios Tzalamouras, Pinelopi Giannakopoulou, Aggeliki D. Mavrogianni, Michael Y. Henein, John Zarifis   +12 more
doaj   +1 more source

Assessment of Pericardial Fat Volume by Cardiac CT and Its Relation With Coronary Heart Diseases

Egyptian Journal of Critical Care Medicine, 2023
Background Coronary artery disease (CAD) is the leading cause of morbidity and mortality. Pericardial fat includes both epicardial (located within the pericardium) and paracardial fat (located superficial to the pericardium).
Soliman Belal Soliman, Azza Samy Ali Mohamad Etman, Ragab Hani Mohamad Donkol, Ahmed Mohamad Abo Elyazed Ramadan   +3 more
doaj   +1 more source

Echocardiographic evaluation of coronary artery disease

, 2013
Although the availability and utilization of other noninvasive imaging modalities for the evaluation of coronary artery disease have expanded over the last decade, echocardiography remains the most accessible, cost-effective, and lowest risk imaging ...
Chatzizisis, Ioannis, Murthy, Venkatesh L., Solomon, Scott D.   +2 more
core   +1 more source

Ilexoside K Ameliorates Atherosclerosis by Suppressing CD72hi Macrophages and Blocking CXCL12–CXCR4 Axis to Inhibit Endothelial Pyroptosis

Advanced Science, EarlyView.
CD72hi macrophages drive endothelial pyroptosis and accelerate atherosclerosis through CXCL12–CXCR4‐mediated immune–vascular crosstalk. Ilexoside K suppresses this pathogenic communication by modulating CXCR4‐dependent endothelial responses, reducing inflammation and plaque progression. These findings reveal a macrophage–endothelial regulatory axis and
Xingling He, Sijing Li, Jiahui Chen, Liyu Lin, Xinyu Li, Xiaojiao Zhang, Yihui Zhang, Xingling Chen, Jinjian Guo, Zhongqi Yang, Lu Lu, Shihao Ni   +11 more
wiley   +1 more source

Serum choline levels in patients with stable angina and acute coronary syndromes: Relation to the severity of coronary artery disease

, 2010
Objective We sought to investigate whether serum choline levels are increased across the spectrum of coronary artery disease (CAD) manifestations and correlate with the severity of coronary stenosis.

core   +1 more source

A Hybrid Hierarchical Framework for Quantifying Mechanical Markers in Atherosclerotic Disease Progression: A New Approach for Diagnosis and Risk Assessment

Advanced Science, EarlyView.
The mechanobiological basis of atherosclerotic progression and its contribution to spatial and temporal heterogeneity remain incompletely understood. Spatially resolved AFM measurements revealed that plaque formation and distinct regions (cap fibrosis, intimal fibrosis, and lipid‐rich core) exhibit heterogeneous elastic modulus and viscoelastic ...
Yidan Zhou, Zhuo Chang, Xianjun Wu, Sijie Wang, Yuzhi Zhang, Hao Zhang, Haoyu Xu, Ruining Peng, Zhe Wang, Huiyun Xu, Yu Liu, Guangkui Xu, Nu Zhang, Hui Yang   +13 more
wiley   +1 more source

Value of Coronary Artery Calcium Scoring in Iranian Patients Suspected to Coronary Artery Disease

Acta Medica Iranica, 2015
Coronary artery calcium scoring (CACS) is a reasonable test for patients with the possibility of atherosclerosis. It can also be used for reclassifying the coronary artery disease (CAD) to the high-risk status by higher CACS and subsequently modifying ...
Amir Farhang Zand Parsa, Naser Gilani Larimi, Marzie Motevali, Ali Macvand Gholipour, Mostafa Rezaei Shahreza, Faraz Ranjpoor, Mohammad Mostafa Dashti   +6 more
doaj  

Cancer-related deaths among different treatment options in chronic coronary artery disease: results of a 6-year follow-up of the MASS II study

, 2012
Introduction The primary end points of randomized clinical trials evaluating the outcome of therapeutic strategies for coronary artery disease (CAD) have included nonfatal acute myocardial infarction, the need for further revascularization, and overall ...
Rezende, Paulo Cury, Favarato, Desiderio, Ramires, Jose A. F., Whady Hueb, Alexandre C. Pereira, Alexandre C. Hueb, Hueb, Alexandre C., Paulo Cury Rezende, Eduardo G. Lima, Garzillo, Cibele L., Lima, Eduardo G., Desiderio Favarato, Bernard J. Gersh, Pereira, Alexandre C., Cibele L. Garzillo, José A.F. Ramires, Vieira, Ricardo D., Hueb, Whady, Gersh, Bernard J., Ricardo D. Vieira   +19 more
core   +1 more source

Extracellular Vesicle Packaged TDP43 Derived From ECs Exacerbates Cigarette Tar‐Related Atherosclerosis Progression via Enhancing Macrophage Extracellular Traps

Advanced Science, EarlyView.
Cigarette tar triggers EC‐derived EVs carrying TDP43, which binds VDAC1 to boost MAMs, mitochondrial Ca2+ overload, and METs formation in macrophages, accelerating smoking‐related AS progression, while retinoic acid binds TDP43 to block this pathogenic cascade.
Xinxin Zhu, Yuwu Chen, Wei Meng, Biyi Xu, Junke Mou, Xiaolin Liu, Mengyang Wang, Qishuo Gu, Qianhui Sun, Man Li, Chen Zhao, Ming Zeng, Ying Lv, Boling Yi, Sheng Qu, Xiaoxuan Bai, Ji Li, Xing Luo, Sining Hu, Bo Yu, Haibo Jia   +20 more
wiley   +1 more source