Results 131 to 140 of about 1,815,731 (375)

Mitochondrial Transplantation Augments the Reparative Capacity of Macrophages Following Myocardial Injury

open access: yesAdvanced Science, EarlyView.
Mitochondrial transplantation induces macrophage polarization toward an anti‐inflammatory M2 phenotype, enhances their reparative capacities, and facilitates mitochondrial transfer to cardiomyocytes, collectively promoting tissue repair and functional recovery post‐myocardial infarction.
Yuning Zhang   +10 more
wiley   +1 more source

Loss of Hepatic Angiotensinogen Attenuates Diastolic Dysfunction in Heart Failure with Preserved Ejection Fraction

open access: yesAdvanced Science, EarlyView.
Increased hepatic angiotensinogen (AGT) abundance leads to cardiac diastolic dysfunction via the AngII‐independent pathway. Liver‐derived AGT is internalized by LRP2 in cardiac endothelial cells, subsequently contributing to myocardial diastolic dysfunction by suppressing microvascular angiogenesis via inhibiting the GATA2/Pim3 pathway.
Zetao Heng   +7 more
wiley   +1 more source

The role of statin drugs in combating cardiovascular diseases –A review [PDF]

open access: yes, 2011
Statins clearly confer substantial benefit in people with established cardiovascular (CV) disease. Increased cholesterol levels have been associated with cardiovascular diseases (CVD), and statins are therefore used in the prevention of these diseases ...
Suresh Pichandi , Palanisamy Pasupathi, Y.Yagneswara Rao, Jawahar Farook, Athimoolam Ambika, Babu Shankar Ponnusha , Sathiyamoorthy Subramaniyam, Rajaram Virumandy, Boopathi subramaniyam Int J Cur Sci Res.
core  

Luminescent Nanocucurbits Enable Spatiotemporal Co‐Delivery of Hydrophilic and Hydrophobic Chemotherapeutic Agents

open access: yesAdvanced Science, EarlyView.
A cucurbit‐shaped luminescent nanoparticle (nanocucurbit) is engineered through the self‐assembly of polypeptides conjugated with aggregation‐induced emission (AIE) fluorophore. The resulting nanocucurbit exhibits approximately two‐fold higher cellular internalization efficiency compared to its spherical counterparts.
Ping Wei   +4 more
wiley   +1 more source

Inhibition of Macrophage ARID3A Alleviates Myocardial Ischemia‐Reperfusion Injury After Heart Transplantation by Reducing THBS1/CD47 Signaling‐Mediated Neutrophil Extracellular Traps Formation

open access: yesAdvanced Science, EarlyView.
This study reveals that ARID3A in macrophages can transcriptionally regulate the THBS1‐CD47 axis after heart transplantation (HT), thereby inducing activated neutrophils to release NETs through the p38 MAPK signaling pathway. The itaconate derivative 4‐OI can inhibit ARID3A in macrophages and promote the accumulation of antioxidant factors, thereby ...
Hao Tian   +7 more
wiley   +1 more source

High‐Throughput Strategies for Streamlining Lipid Nanoparticle Development Pipeline

open access: yesAdvanced Science, EarlyView.
This review highlights emerging state‐of‐the‐art high‐throughput strategies for optimising lipid nanoparticle formulation. By integrating combinatorial design, characterization, in vitro/in vivo screening, automation, and machine learning into a closed‐loop framework, it provides a roadmap to streamline discovery and accelerate the translation of ...
Lois Lam   +3 more
wiley   +1 more source

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