Results 71 to 80 of about 33,487 (265)

Ultrasound‐Boosted Liposomal Prodrug Overcomes Age‐Associated Biodistribution Disparity in Pediatric Solid Tumor Therapy

Advanced Science, EarlyView.
The age‐associated disparity of nanocarrier biodistribution limits the nanotherapeutics of childhood solid tumors. This study developed an ultrasound‐activated liposomal prodrug (CSCPTL) to overcome the age‐associated disparity of off‐target distribution.
Danfei Chen, Junjun Xu, Jian Chen, Jue Hu, Xiaobo Xuan, Haifang Cai, Mingdong Yang, Zhuxian Zhou, Guowei Wang   +8 more
wiley   +1 more source

Mendelian Randomization and Double Machine Learning Modeling Reveal Brain Imaging‐Derived Phenotypes as Functional Contributors to 18 Autoimmune Inflammatory Diseases

Advanced Science, EarlyView.
This schematic integrates the eight statistically significant causal relationships identified between 1,366 brain imaging‐derived phenotypes (IDPs) and 18 autoimmune inflammatory diseases (AIDs). Arrows indicate the direction of causality inferred from bidirectional two‐sample MR analyses.
Jinbin Chen, Xin Wang, Haifeng Ding, Bosheng Zheng, Keni Zeng, Chuying Hu, Jiayi Liu, Xiao Zhu, Haibing Yu   +8 more
wiley   +1 more source

Prognostic value of Doppler echocardiographic-derived coronary flow velocity reserve of left anterior descending artery in octogenarians with stress echocardiography negative for wall motion criteria [PDF]

, 2015
Lauro Cortigiani, F Rigo, Sonia Gherardi, Francesco Bovenzi, E. Picano, Rosa Sicari   +5 more
openalex   +1 more source

Endothelial Cell‐Specific Molecule‐1 (ESM1): An Endogenous Anticoagulant and Protective Factor in Venous Thrombosis

Advanced Science, EarlyView.
This study identifies ESM1 as an endogenous anticoagulant that modulates venous thrombosis. It shows that ESM1 deficiency triggers vascular occlusion in zebrafish and mice, whereas its restoration or overexpression prolongs clot‐formation time. Mechanistic analyses reveal that ESM1 activates HCII through its dermatan‐sulfate chain, uncovering a ...
Changsheng Chen, Xiaojuan Ge, Dongxu Fu, Haijun Mei, Feng Lv, Chao Yang, Jiahao Lu, Xiaozhong Shen, Bowen Li, Xiaoning Wang, Dong Liu   +10 more
wiley   +1 more source

Neuroprotective Nanoplatform Integrating Antioxidant MXene Nanozymes and Ferroptosis Inhibitors for Targeted Therapy of Cerebral Ischemia‐Reperfusion Injury

Advanced Science, EarlyView.
Cerebral ischemia‐reperfusion injury (CIRI) is a key pathological process limiting the efficacy of stroke therapy. This study has developed an innovative, multifunctional, brain‐targeted nanoplatform (RFP) containing MXene nanoenzymes and ferroptosis inhibitors.
Lu Wang, Chao Hou, Shuo Li, Lizhi Yang, Yiqun Lin, Sen Wang, Xiaohua Jia, Hui Hui, Wen He, Wei Zhang   +9 more
wiley   +1 more source

Diagnostic Agreement of Quantitative Flow Ratio With Fractional Flow Reserve and Instantaneous Wave‐Free Ratio

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019
Background Quantitative flow ratio (QFR) has a high diagnostic accuracy in assessing functional stenoses relevance, as judged by fractional flow reserve (FFR). However, its diagnostic performance has not been thoroughly evaluated using instantaneous wave‐
Doyeon Hwang, Ki Hong Choi, Joo Myung Lee, Hernán Mejía‐Rentería, Jihoon Kim, Jonghanne Park, Tae‐Min Rhee, Ki‐Hyun Jeon, Hyun‐Jong Lee, Hyun Kuk Kim, Taek Kyu Park, Jeong Hoon Yang, Young Bin Song, Eun‐Seok Shin, Chang‐Wook Nam, Jae‐Jin Kwak, Joon‐Hyung Doh, Joo‐Yong Hahn, Jin‐Ho Choi, Seung‐Hyuk Choi, Javier Escaned, Bon‐Kwon Koo, Hyeon‐Cheol Gwon   +22 more
doaj   +1 more source

Prevalence and correlation of abnormal flow reserve by stress CMR and coronary artery plaque by cardiac CTA in symptomatic diabetics [PDF]

, 2014
Yasmin S. Hamirani, Michael Salerno, Yang Yang, Christopher M. Kramer, Jamieson M. Bourque   +4 more
openalex   +1 more source

Sex-specific risk for ischemia by invasive fractional flow reserve according to coronary atherosclerotic features: results from the CREDENCE trial [PDF]

, 2020
Inge J. van den Hoogen, Umberto Gianni, A. Maxim Bax, Alexander R. van Rosendael, Sara W. Tantawy, Daniel S. Berman, Hyuk‐Jae Chang, Philippe Généreux, Paul Knaapen, Jagat Narula, Gianluca Pontone, Fay Y. Lin, James K. Min, Leslee J. Shaw, Jeroen J. Bax   +14 more
openalex   +1 more source

Esketamine/Ketamine: Dual‐Action Mechanisms and Clinical Prospects beyond Anesthesia in Psychiatry, Immunology, and Oncology

Advanced Science, EarlyView.
Esketamine and ketamine are widely used for perioperative analgesia and anesthesia. Despite their established roles in analgesia, sedation, and anesthesia, as well as emerging antidepressant, anti‐tumor, and anti‐inflammatory effects, their clinical use is limited due to side effects and addiction potential.
Yinxin Wang, Jiangang Xu, Xinyu Zhou, Lu Che, Minghan Qiu, Yang Liu, Ming Gao, Zhen Yang   +7 more
wiley   +1 more source

Detecting lesion-specific ischemia in patients with coronary artery disease with computed tomography fractional flow reserve measured at different sites [PDF]

, 2023
Zhaoxi Cai, Taihui Yu, Zehong Yang, Huijun Hu, Yongqing Lin, Haifeng Zhang, Meiwei Chen, Guangzi Shi, Jun Shen   +8 more
openalex   +1 more source