Results 51 to 60 of about 30,001 (261)

Coronary flow reserve in patients with normal coronary angiograms

Journal of the American College of Cardiology, 1985
It has been estimated that 20% of patients who undergo coronary angiography for the evaluation of chest pain have angiographically normal coronary vessels with no other car• diac cause for their discomfort. Although the natural history of this patient group is favorable (1-3), the mechanisms responsible for the pain frequently remain mysterious. In the
Marcus, Melvin L., White, Carl W.
openaire   +2 more sources

One‐Step Microfluidic Manufactured Fucose‐Decorated Sweetosomes Choose the Time and the Road for Their Intracellular Journey to Cancer Treatment

Advanced Healthcare Materials, EarlyView.
Sweetosomes, a new class of fucose‐decorated liposomes, are developed via a one‐step microfluidic process without surface chemistry. This study elucidates their main caveolae‐mediated entry and distinct endosomal trafficking. These nanostructures demonstrate superior endosomal escape, organelle acidity modulation, and prolonged plasma persistence ...
Mattia Tiboni, Mariele Montanari, Shiva Khorshid, Michele Verboni, Andrea Duranti, Simone Lucarini, Daniele Lopez, Annalisa Aluigi, Gianluca Morganti, Michele Menotta, Giovanna Panza, Daniel J. Klionsky, Barbara Canonico, Luca Casettari   +13 more
wiley   +1 more source

DIAGNOSTIC ACCURACY OF FFRACTIONAL FLOW RESERVE IN DIAGNOSING STENTABLE INTERMEDIATE STENOSIS IN PATIENTS OF CORONARY ARTERY DISEASE KEEPING ANGIOGRAPHY AS A GOLD STANDARD

Pakistan Armed Forces Medical Journal, 2020
Objective: To determine diagnostic accuracy of fractional flow reserve in diagnosing stentable intermediate stenosis in patients of coronary artery disease keeping angiography as gold standard. Study Design: Cross sectional validation study.
Abid Saeed, Muhammad Fareed, Abid Sharif, Salma Younas, Fatima Gul   +4 more
doaj  

Coronary Microcirculation Downstream Non‐Infarct‐Related Arteries in the Subacute Phase of Myocardial Infarction: Implications for Physiology‐Guided Revascularization

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019
Background Concerns exist about reliability of pressure‐wire‐guided coronary revascularization of non‐infarct‐related arteries (non‐IRA). We investigated whether physiological assessment of non‐IRA during the subacute phase of myocardial infarction might
Hernán Mejía‐Rentería, Joo Myung Lee, Nina W. van der Hoeven, Nieves Gonzalo, Pilar Jiménez‐Quevedo, Luis Nombela‐Franco, Iván J. Núñez‐Gil, Pablo Salinas, María Del Trigo, Enrico Cerrato, Niels van Royen, Paul Knaapen, Bon‐Kwon Koo, Carlos Macaya, Antonio Fernández‐Ortiz, Javier Escaned   +15 more
doaj   +1 more source

Non-invasive imaging software to assess the functional significance of coronary stenoses: a systematic review and economic evaluation

Health Technology Assessment, 2021
Background: QAngio® XA 3D/QFR® (three-dimensional/quantitative flow ratio) imaging software (Medis Medical Imaging Systems BV, Leiden, the Netherlands) and CAAS® vFFR® (vessel fractional flow reserve) imaging software (Pie Medical Imaging BV, Maastricht,
Ana Duarte, Alexis Llewellyn, Ruth Walker, Laetitia Schmitt, Kath Wright, Simon Walker, Claire Rothery, Mark Simmonds   +7 more
doaj   +1 more source

Shellac‐Mediated Assembly of Nanoparticles for mRNA Delivery

Advanced Healthcare Materials, EarlyView.
A shellac‐mediated nanoparticle assembly strategy is presented, involving the complexation of mRNA and low‐molecular‐weight cationic molecules (e.g., polyethyleneimine, chitosan, lipids, and poly‐l‐lysine), followed by capping with shellac. This nanoparticle platform enables mRNA transfection following intravenous injection and facilitates gene editing
Meizhang Lu, Jingqu Chen, Zhixing Lin, Wanjun Xu, Tianzheng Wang, Shiyao Li, Die Yang, Frank Caruso   +7 more
wiley   +1 more source

The new clinical standard of integrated quadruple stress echocardiography with ABCD protocol

Cardiovascular Ultrasound, 2018
Background The detection of regional wall motion abnormalities is the cornerstone of stress echocardiography. Today, stress echo shows increasing trends of utilization due to growing concerns for radiation risk, higher cost and stronger environmental ...
Eugenio Picano, Quirino Ciampi, Karina Wierzbowska-Drabik, Mădălina-Loredana Urluescu, Doralisa Morrone, Clara Carpeggiani   +5 more
doaj   +1 more source

Functional Blood‐Brain Barrier Crossing by Biomimetic M13 Phage Vectors for Targeted Neuronal Delivery

Advanced Healthcare Materials, EarlyView.
This study investigates the M13 bacteriophage as a biomimetic nanovector capable of crossing in vitro models of the blood–brain barrier. By exploiting peculiar transcellular pathways, M13 avoids lysosomal degradation and preserves its structural integrity and functionality.
Silvia Vercellino, Lucia Pappagallo, Francesca De Chirico, Luca Boselli, Hazem Ahmed, Luca Spagnoletti, Giovanni Pittaluga, Paolo Emidio Costantini, Matteo Calvaresi, Pier Paolo Pompa, Alberto Danielli, Fabio Benfenati, Valentina Castagnola   +12 more
wiley   +1 more source

CXCR2 Inhibition – a novel approach to treating CoronAry heart DiseAse (CICADA): study protocol for a randomised controlled trial

Trials, 2017
Background There is emerging evidence of the central role of neutrophils in both atherosclerotic plaque formation and rupture. Patients with lower neutrophil counts following acute coronary syndromes tend to have a greater coronary flow reserve, which is
Jubin P. Joseph, Eliana Reyes, Josephine Guzman, Jim O’Doherty, Hannah McConkey, Satpal Arri, Rahul Kakkar, Nicholas Beckley, Abdel Douiri, Sally F. Barrington, Simon R. Redwood, Albert Ferro   +11 more
doaj   +1 more source

An intact animal model for the assessment of coronary blood flow regulation “Coronary blood flow regulation”

Physiological Reports, 2020
Coronary blood flow adapts to metabolic demand ("metabolic regulation") and remains relatively constant over a range of pressure changes ("autoregulation"). Coronary metabolic regulation and autoregulation are usually studied separately.
Céline Boudart, Fuhong Su, Antoine Herpain, Jacques Creteur, Robert Naeije, Serge Brimioulle, Laurence Dewachter, Luc Van Obbergh   +7 more
doaj   +1 more source