Results 111 to 120 of about 1,479,889 (356)

Reengineering Endogenous Targeting Lipid Nanoparticles (ENDO) for Systemic Delivery of mRNA to Pancreas

Advanced Materials, EarlyView.
ENDO lipid nanoparticles containing cholecalciferol as a fifth component demonstrate mRNA delivery to the pancreas with 99% selectivity, including beta cells. This platform shows minimal toxicity and sustained protein expression for up to 3 days in a dose‐dependent manner, offering a novel approach to pancreas‐specific mRNA delivery and gene therapy ...
Ivan Isaac, Luv Patel, Nguyen Tran, Amarnath Singam, DongSoo Yun, Prasun Guha, Seungman Park, Chandrabali Bhattacharya   +7 more
wiley   +1 more source

Education and coronary heart disease: mendelian randomisation study

British medical journal, 2017
Objective To determine whether educational attainment is a causal risk factor in the development of coronary heart disease. Design Mendelian randomisation study, using genetic data as proxies for education to minimise confounding.
T. Tillmann, J. Vaucher, A. Okbay, H. Pikhart, A. Peasey, R. Kubínová, A. Pająk, A. Tamošiūnas, S. Malyutina, F. Hartwig, K. Fischer, G. Veronesi, T. Palmer, J. Bowden, G. Davey Smith, M. Bobák, M. Holmes   +16 more
semanticscholar   +1 more source

Nanostructured 316L Stainless Steel Stent Surfaces Improve Corrosion Resistance, and Enhance Endothelization and Hemocompatibility

Advanced Materials Interfaces, EarlyView.
This study investigates the impact of nanostructured surface modification on corrosion resistance, HUVEC functions, and platelet interactions of 316L SS for cardiovascular stents. Nanostructured surfaces enhanced HUVEC proliferation, migration, and angiogenesis‐related gene expression while reducing platelet adhesion and hemolysis.
Yasar Kemal Erdogan, Pelin Mutlu, Batur Ercan   +2 more
wiley   +1 more source

Association between IL-2 Receptor and Severe Coronary Artery Calcification in Patients with Coronary Artery Disease

Reviews in Cardiovascular Medicine
Background: Coronary artery calcification (CAC) is a crucial marker for coronary atherosclerosis, and the extent of CAC is closely linked to the incidence and progression of cardiovascular diseases.
Chenyang Wang, Sheng Liu, Raimov Kamronbek, Siyao Ni, Kexin Yang, Yunxiao Yang, Daliang Zhou, Can Zhou, Chengqian Yin, Ming Zhang   +9 more
doaj   +1 more source

Coronary Heart Disease: Angina Pectoris: Myocardial Infarction [PDF]

, 1958

openalex   +2 more sources

Flow Analysis in Pathological Microvascular Models by Ultrasound Localization Microscopy

Advanced Materials Technologies, EarlyView.
This study presents a new platform combining ultrasound localization microscopy with biomimetic gelatin phantoms to analyze flow dynamics in small vessels with narrowing or obstructions. Using microbubble tracking, the method enables high‐resolution velocity mapping in 100–500 µm channels, revealing flow changes in pathological microvascular conditions
Yarin Gershman, Grigori Shapiro, Tamar Mano, Tali Ilovitsh   +3 more
wiley   +1 more source

New Insights into the Association between Fibrinogen and Coronary Atherosclerotic Plaque Vulnerability: An Intravascular Optical Coherence Tomography Study

Cardiovascular Therapeutics, 2019
Background. Fibrinogen levels have been associated with coronary plaque vulnerability in experimental studies. However, it has yet to be determined if serum fibrinogen levels are independently associated with coronary plaque vulnerability as detected by ...
Jun Wang, Lu Jia, Xing Li, Siyu Jin, Xiaomei Li, Fen Liu, Chunfang Shan, Yu Zhang, Yining Yang   +8 more
doaj   +1 more source

Gender differences in coronary heart disease

Heart, 2016
### Learning objectives The importance of coronary heart disease (CHD) as a disease of both genders tends to be underappreciated, although in 2014 CHD claimed almost three times more lives than breast cancer.
R. Khamis, T. Ammari, G. Mikhail
semanticscholar   +1 more source

Miniaturized Devices for On‐the‐Spot Generation of Small‐Diameter Vascular Grafts

Advanced Materials Technologies, EarlyView.
An intracorporeal extrusion device is developed for on‐the‐spot generation of vascular grafts with tunable diameters spanning from 1 to 6 mm. The device uses biomimetic polymers and light, to promptly obtaining biocompatible and high‐burst pressure‐resistant grafts.
Deyanira Hernandez‐Sanchez, Maxime‐Emmanuel Comtois‐Bona, Antony El‐Khoury, Sergio David Garcia Schejtman, Aidan Macadam, Juan‐David Figueroa‐Alegria, Jesus M. Calderon‐Torres, Irene Guzmán‐Soto, Marc Ruel, Erik J. Suuronen, Marcelo Muñoz, Emilio I. Alarcon   +11 more
wiley   +1 more source

Reappraisal of Ischemic Heart Disease: Fundamental Role of Coronary Microvascular Dysfunction in the Pathogenesis of Angina Pectoris

Circulation, 2018
In recent years, it has become apparent that coronary microvascular dysfunction plays a pivotal pathogenic role in angina pectoris. Functional and structural mechanisms can affect the physiological function of the coronary microvasculature and lead to ...
J. Kaski, F. Crea, B. Gersh, P. Camici
semanticscholar   +1 more source