Results 131 to 140 of about 1,033,375 (338)

The optimal treatment of multivessel coronary artery disease [PDF]

open access: yes, 2014
The practice of percutaneous coronary intervention has overtaken coronary bypass surgery in the treatment of ischaemic heart disease. Several randomized controlled as well as registry and observational trials have addressed the issue of patient selection
Manche, Alexander
core  

Endogenous “Time Bomb” – Mislocalized Phospholipase A2 as a Critical Mediator of Ultra‐Rapid Mortality in Sepsis and Acute Lung Injury

open access: yesAdvanced Science, EarlyView.
Phospholipase A2 (PLA2), a dormant enzyme, becomes lethal when activated—collapsing lungs in minutes. Our dual therapy (DOPS + varespladib) boosts survival from 0% to >90% in sepsis/ALI. A breakthrough for acute lung injury treatment. ABSTRACT This study reveals that phospholipase A2 (PLA2), normally stable and nontoxic, can be activated specifically ...
Jianyu Wang   +7 more
wiley   +1 more source

Rapid Remodeling of the Human Gut Microbiome in Response to Short‐Term Animal Product Restriction and Associations with Host Molecular Phenotypes

open access: yesAdvanced Science, EarlyView.
A real‐world model of structured animal product restriction practiced for religious reasons reveals the dynamic adaptability of the human gut microbiome to dietary change and uncovers reductions in diversity and rare taxa loss. Integrated microbiome, metabolomic, and proteomic analyses uncover coordinated taxonomic and molecular shifts and identify ...
Christina Emmanouil   +7 more
wiley   +1 more source

Potential Mechanisms of Epicardial Adipose Tissue Influencing HeartFailure with Preserved Ejection Fraction

open access: yesReviews in Cardiovascular Medicine
Heart failure (HF) is the predominant terminal stage and the leading cause ofmortality in cardiac disease. Heart failure with preserved ejection fraction(HFpEF) affects roughly 50% of HF patients globally.
Qiuxuan Li   +5 more
doaj   +1 more source

Plasma urate concentration and risk of coronary heart disease: a Mendelian randomisation analysis [PDF]

open access: yes, 2016
BACKGROUND: Increased circulating plasma urate concentration is associated with an increased risk of coronary heart disease, but the extent of any causative effect of urate on risk of coronary heart disease is still unclear.
Hemani, G, Shah, T, Sofat, R, White, J
core  

Organ‐Specific and Conserved Regulatory Logic Orchestrates Gene Expression in the Embryonic Mesothelium

open access: yesAdvanced Science, EarlyView.
Integrated multi‐omic profiling maps the gene‐regulatory landscape of the coelomic mesothelium across heart, lung, and pancreas. A cardiac‐restricted regulatory program is uncovered in which TBX20 activates heart mesothelial (epicardial) cis‐regulatory elements, while MAF emerges as a conserved regulator of mesothelial identity.
Quang Minh Dang   +3 more
wiley   +1 more source

Prevalensi Faktor Risiko Orang Dewasa yang Memiliki Gejala Subjektif Penyakit Jantung Koroner di Gunung Kidul [PDF]

open access: yes, 2016
The prevalence of risk factors in adults who have subjective coronary heart disease symptoms in Gunung KidulPurposeThis study aimed to identify the risk factors of smoking, passive smoking, physical activity, and consumption of fruits and vegetables in ...
Indriani, C. (Citra)   +2 more
core  

Oil‐Coated Nanoplastics Induce Rapid Membrane Disruption and Severe Intestinal Injury

open access: yesAdvanced Science, EarlyView.
Oil‐rich food contact dramatically amplifies MNP release from plastic takeout containers, producing oil‐coated nanoplastics with altered surface properties and rapid membrane‐disruptive effects. These particles cause severe intestinal barrier damage and immune dysfunction in mice, and risk modeling suggests that long‐term gastrointestinal burdens may ...
Ruwen Xie   +17 more
wiley   +1 more source

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