Results 41 to 50 of about 1,033,375 (338)

A Review of Neurogenic Stunned Myocardium. [PDF]

, 2017
Neurologic stunned myocardium (NSM) is a phenomenon where neurologic events give rise to cardiac abnormalities. Neurologic events like stroke and seizures cause sympathetic storm and autonomic dysregulation that result in myocardial injury.
Agrawal, Akanksha, Biso, Sylvia, Figueredo, Vincent M., Kishlyansky, Marina, Wongrakpanich, Supakanya, Yadlapati, Sujani   +5 more
core   +3 more sources

Oxidative Stress–Related Genome-Wide Mendelian Randomization Identifies Causal Genes for Coronary Artery Disease

Cardiovascular Therapeutics
Although oxidative stress (OS) links to the pathogenesis of coronary artery disease (CAD), its underlying genetic mechanisms remain unclear. Through summary data–based Mendelian randomization (SMR) and colocalization, this research seeks to assess the ...
Hongliang Zhang, Jingsheng Feng, Wence Shi, Guannan Niu, Yanqin Zheng, Zhenyan Zhao, Moyang Wang, Zheng Zhou, Zhe Li, Yongjian Wu   +9 more
doaj   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Effects of Sodium–Glucose Cotransporter 2 Inhibitors on Stage 4 Cardiovascular–Kidney–Metabolic Syndrome: A Propensity Score–Matched Study

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background This study investigated the effects of sodium–glucose cotransporter 2 inhibitors (SGLT2is) on patients with stage 4 cardiovascular–kidney–metabolic syndrome over 1 year.
Tao Liu, Zeyuan Fan, Yuntao Li, Bing Xiao, Chang He   +4 more
doaj   +1 more source

Prognostic impact of the atherogenic index of plasma in type 2 diabetes mellitus patients with acute coronary syndrome undergoing percutaneous coronary intervention

Lipids in Health and Disease, 2020
Background The association of the atherogenic index of plasma (AIP), an emerging lipid index that can predict the risk for cardiovascular disease, with adverse outcomes in type 2 diabetes mellitus (T2DM) patients with acute coronary syndrome (ACS ...
Xiaoteng Ma, Yan Sun, Yujing Cheng, Hua Shen, Fei Gao, Jing Qi, Lixia Yang, Zhijian Wang, Dongmei Shi, Yuyang Liu, Xiaoli Liu, Yujie Zhou   +11 more
doaj   +1 more source

The relation between atherogenic index of plasma and cardiovascular outcomes in prediabetic individuals with unstable angina pectoris

BMC Endocrine Disorders, 2023
Background The atherogenic index of plasma (AIP) is a novel biomarker associated with atherosclerosis, and an important risk factor for atherosclerosis, but its relation with cardiovascular prognosis in prediabetic patients with unstable angina pectoris (
Yang Liu, Xunxun Feng, Jiaqi Yang, Guangyao Zhai, Bin Zhang, Qianyun Guo, Yujie Zhou   +6 more
doaj   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Association of sodium-glucose cotransporter 2 inhibitors with risk of major adverse cardiovascular events in type 2 diabetes patients with acute coronary syndrome: a propensity score‑matched analysis

Cardiovascular Diabetology
Background This study aimed to investigate the association of sodium-glucose cotransporter 2 inhibitors (SGLT2i) use with cardiovascular (CV) clinical outcomes in type 2 diabetes (T2D) patients with acute coronary syndrome (ACS).
Tao Liu, Zeyuan Fan, Bing Xiao, Chang He, Shicong Wang   +4 more
doaj   +1 more source

CX3CL1 in Early Detection of Alzheimer's Disease: Plasma Dynamics Across Age and Disease Stages

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Backgrounds Alzheimer's disease (AD) is characterized by amyloid‐beta plaques, tau tangles, and neuroinflammation. C‐X3‐C motif chemokine ligand 1 (CX3CL1, also known as fractalkine), a neuroimmune chemokine implicated in AD pathogenesis, shows inconsistent alterations in plasma/serum across studies.
Ling Wang, Yujie Liu, Fei Li, Xuelin Li, Lanlan Li, Jie Zhang, Yali Xu   +6 more
wiley   +1 more source

IL-6 and lL-17 as potential biomarkers for premature coronary artery disease: a cross-sectional study

BMC Cardiovascular Disorders
Background Coronary artery disease (CAD) is a chronic inflammatory condition, with cytokines playing a crucial role. However, their involvement in premature CAD (pCAD) remains unclear.
Kexin Yang, Sheng Liu, Chenyang Wang, Siyao Ni, Zhijian Yue, Ludan Bi, Yunxiao Yang, Ming Zhang   +7 more
doaj   +1 more source