Results 91 to 100 of about 97,579 (254)

A Huaxian Formula Nanoformulation Confers Protection Against Acute Radiation‐Induced Lung Injury by Targeting Ferroptosis

Advanced Science, EarlyView.
An inhalable, nanoengineered herbal therapy achieves protection against acute radiation‐induced lung injury via self‐assembled nanomicelle‐mediated pulmonary targeting and a previously unrecognized dual mechanism that attenuates oxidative stress while inhibiting ferroptosis in alveolar epithelial cells.
Li Quan, Junyang Chen, Xingmin Chen, Zengyi Fang, Yuanzhen Mi, Pingjin Zou, Shunlian Fu, Huakang Li, Ke Xu, Bing Lin, Jinyi Lang, Meihua Chen   +11 more
wiley   +1 more source

The Advancement in Coronary Physiology

Ischemic heart disease (IHD) remains the leading global cause of mortality, underscoring the need for precise physiological assessments for accurate diagnosis and effective management. Both the epicardial coronary arteries and the coronary microvasculature contribute to IHD, making it essential to evaluate both components using appropriate diagnostic ...
Kazumasa Ikeda, Jun Yamashita, Kazuhiro Satomi, Hideaki Kanazawa   +3 more
openaire   +1 more source

14‐3‐3γ Protects Against Postoperative Cognitive Dysfunction by Regulating Tau Thr205 Phosphorylation and Synaptic Integrity

Advanced Science, EarlyView.
Integrative multi‐cohort analyses identify 14‐3‐3γ as a biomarker and regulator of cognitive vulnerability. Experimental studies show that 14‐3‐3γ loss is associated with Tau Thr205 phosphorylation, synaptic dysfunction, and cognitive impairment, while genetic overexpression or pharmacological stabilization of 14‐3‐3γ confers protective effects in ...
Shouqiang Zhu, Xue Han, Heng Zhang, Chang Ye, Tianjiao Xia, Xiaoping Gu   +5 more
wiley   +1 more source

Quantitative Visualization of Intracellular Nanometabolism Using Peak‐Shifted Dual‐State Emissive FRET Nanoprobes

Advanced Science, EarlyView.
This study reveals the long‐elusive intracellular dissolution mechanism of carrier‐free nanomedicines. By utilizing peak‐shifted dual‐state emissive FRET nanoprobes (PDFNPs) that undergo a distinct ratiometric fluorescence peak shift upon disassembly, we achieve real‐time, quantitative tracking of dissolution kinetics in live cells.
Farsai Taemaitree, Jinwoo Sung, Yutaro Miki, Ryuju Suzuki, Yoshitaka Koseki, Kunikazu Ishii, Minsang Kim, Keita Tanita, Kota Sato, Toru Nakazawa, Satoshi Katsube, Daisuke Unabara, Tasuku Hamaguchi, Keisuke Kawakami, Koji Yonekura, Akihide Hibara, Atsushi Wakamiya, Hiroshi Uji‐I, Hitoshi Kasai   +18 more
wiley   +1 more source

Application of intravascular physiology methods in clinical practice: two-year data from the Russian registry

Российский кардиологический журнал
Aim. To analyze the use in clinical practice of intravascular coronary assessment methods based on two-year data from the Russian Registry on the Use of Intravascular Imaging and Physiology.Material and methods.
V. V. Demin, A. M. Babunashvili, T. V. Kislukhin, E. Yu. Kostyrin, Z. Kh. Shugushev, V. N. Ardeev, E. V. Merkulov, Yu. G. Matchin, E. Yu. Gubarenko, N. A. Kochergin, S. P. Semitko, A. A. Anufriev, A. V. Ter-Akopyan, D. V. Teplyakov, O. E. Zauralov, G. K Arutyunyan, R. F. Atanesyan, D. A. Asadov, V. A. Ignatov, A. V. Azarov   +19 more
doaj   +1 more source

A Scalable Spin‐Coating Strategy for Mesoporous Gold Thin Films toward miRNA Detection

Advanced Science, EarlyView.
A scalable spin‐coating strategy produces uniform mesoporous Au thin films with tunable thickness and high electroactive surface area on transparent substrates. The resulting architecture enables label‐free, amplification‐free detection of ovarian cancer‐associated miRNA hsa‐miR‐200c‐3p from 1 aM to 10 pM, achieving a 1.72 aM detection limit with high ...
Aditya Ashok, Emtiaz Ahmed, Arya Vasanth, Mandy Hei Man Leung, Miharu Eguchi, Md Shahriar A. Hossain, Mostafa Kamal Masud, Carlos Salomon, Yusuke Yamauchi   +8 more
wiley   +1 more source

Coronary physiology revisited [PDF]

Netherlands Heart Journal, 2017
openaire   +2 more sources

Longitudinal Multifrequency MR Elastography Reveals Biomechanical Signatures of Progression in a Translational Liver Tumor Model

Advanced Science, EarlyView.
Longitudinal multifrequency magnetic resonance elastography (mMRE) performed on a clinical 3 Tesla magnetic resonance imaging system reveals early biomechanical alterations during liver tumor progression in a translational VX2 model. Changes in tumor stiffness and viscosity precede diffusion‐related alterations and are associated with extracellular ...
Justus Ramtke, Friederike Hesse, Lasse Noack, Justus Klockner, Yubei He, Yu Liu, Yanglei Wu, Robin Schmidt, Selma Saclier, Salma A. S. Abosabie, Tom Meyer, Richard Ruppel, Nikolaus Berndt, Michael Mülleder, Eyk Schellenberger, Nicola Beindorff, Dominik N. Müller, Ingolf Sack, Jing Guo, Shraga Nahum Goldberg, Lynn Jeanette Savic   +20 more
wiley   +1 more source

Real‐World Outcomes of FFRangio‐Guided Treatment for Coronary Artery Disease in Acute Versus Chronic Coronary Syndromes

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background The use of angiogram‐based fractional flow reserve technologies in routine clinical practice is increasing steadily. Available data suggest that it is associated with comparable clinical outcomes compared with wire‐based fractional flow ...
Guy Witberg, Yuetsu Kikuta, Kazuhiro Dan, Hiroyoshi Yokoi, Yutaka Hikichi, Mamoru Nanasato, Toru Tanigaki, Yeela Talmor‐Barkan, Amos Levi, Ran Kornowski, Hitoshi Matsuo   +10 more
doaj   +1 more source

Mitochondria‐Targeted Nanotherapeutics: A Promising Strategy in Modulating Mitochondrial Function, Transfer, and Transplantation

Advanced Science, EarlyView.
This review summarizes the pathogenic role of mitochondria in diseases and highlights mitochondrial transfer and transplantation as emerging therapeutic strategies. It systematically discusses how nanomaterials are engineered to facilitate these processes, and critically examines the current challenges and future perspectives for their clinical ...
Yuanyuan Su, Zhiyan Gong, Jiao Mu, Lili Huang, Pengfei Yang, Chenli Zhang, Lingshan Zhao, Liling Yang, Jun Deng, Xiaohui Liao   +9 more
wiley   +1 more source