Results 81 to 90 of about 796,466 (237)

Chromatin Packing Domain Engineering Through the Manipulation of Nuclear Cationic States

open access: yesAdvanced Science, EarlyView.
Manipulation of intranuclear divalent cation concentrations rapidly and reversibly remodels chromatin packing domains in living cells. Magnesium depletion disrupts domain compaction, heterochromatin organization, and transcriptional regulation, whereas magnesium loading promotes more compact and stable domains.
Cody L. Dunton   +13 more
wiley   +1 more source

COMPARATIVE CHARACTERISTICS OF FUNCTIONAL CORONARY RESERVE AND MYOCARDIAL INFARCTION RISK IN PATIENTS WITH THE CARDIAC X SYNDROME AND STENOTIC CORONARY ATHEROSCLEROSIS

open access: yesРоссийский кардиологический журнал, 2001
The aim of this research was to study the functional coronary reserve and frequency of miocardium infarction in patients with cardiologic syndrome X (CX) in comparison with patients with stenosing atherosclerosis of coronary artery (ACA).
V. I. Kostin   +8 more
doaj  

Fractional flow reserve-guided percutaneous coronary intervention: where to after FAME 2?

open access: yes, 2015
Tim P van de Hoef,1 Martijn Meuwissen,2 Jan J Piek1 1AMC Heartcentre, Academic Medical Center, University of Amsterdam, Amsterdam, 2Amphia Hospital, Breda, the Netherlands Abstract: Fractional flow reserve (FFR) is a well-validated clinical coronary ...
Meuwissen M, van de Hoef TP, Piek JJ
core  

Coronary flow reserve assessment by dobutamine transesophageal doppler echocardiography [PDF]

open access: yes, 1995
Objectives. This study attempted to determine the sensitivity and specificity of coronary flow reserve derived using transesophageal echocardiography for left anterior descending coronary artery stenosis.Background.
Stoddard, Marcus F.   +2 more
core   +1 more source

Systematic Multi‐Level Analyses Decode the Arthritis‐Neurodegeneration Axis With In Vivo Validation

open access: yesAdvanced Science, EarlyView.
Arthritis and neurodegeneration are usually studied as separate disorders, but this study connects them through population evidence, genetic inference, transcriptomic mapping, and mouse models. It highlights RNF40 as a context‐dependent joint‐brain candidate, induced in inflammatory joints yet functionally linked to dopamine‐neuron vulnerability ...
Jinwen Wang   +7 more
wiley   +1 more source

The effect of coronary angioplasty on coronary flow reserve.

open access: yes, 1988
To determine the effects of coronary angioplasty on coronary flow reserve (CFR), we studied 32 patients before and immediately after single-vessel coronary angioplasty and 31 patients evaluated late after angioplasty (7.5 +/- 1.2 months, mean +/- SEM ...
S Collins   +6 more
core   +1 more source

Blood Cell‐Camouflaged Liquid Metal Nanoconjugates Orchestrate Treg Depletion and STING‐Amplified Photothermal Immunity for Metastatic Triple‐Negative Breast Cancer Therapy

open access: yesAdvanced Science, EarlyView.
Whole‐blood biomimetic engineering transforms liquid metal nanoparticles into a tripartite immunotherapeutic platform that orchestrates regulatory T‐cell depletion, photothermal‐induced immunogenic cell death, and activation of the stimulator of interferon genes pathway.
Nina Sang, Eijiro Miyako
wiley   +1 more source

OTUD6A‐Mediated Deubiquitination of PRDX1 Protects Against Oral Ulcer by Restoring Mitochondrial Function

open access: yesAdvanced Science, EarlyView.
In human oral keratinocytes, OTUD6A promoted cell migration by deubiquitinating and stabilizing PRDX1. Conversely, OTUD6A deficiency reduced PRDX1 stability, triggering mitochondrial dysfunction and aggravating OU progression. ABSTRACT Oral ulcers (OU), as the most highly prevalent and recurrent oral mucosal lesion, have an unclear pathogenesis that ...
Xiaoyu Sun   +15 more
wiley   +1 more source

Dynamic Single-Photon Emission Computed Tomography Data Analysis: Capabilities for Determining Functional Significance of Coronary Artery Atherosclerosis

open access: yesMATEC Web of Conferences, 2016
The aim of the study was to develop the method for collecting and processing scintigraphic data to determine myocardial flow reserve by using gamma-camera with a new type detector based on Cadmium Zinc Telluride (CZT).
Mochula Andrew   +3 more
doaj   +1 more source

CT-FFR: Clinical Application

open access: yesMajalah Kardiologi Indonesia, 2018
Invasive fractional flow reserve (FFR) is the gold standard for guiding decision making to identify patients who would benefit from revascularization. Now, computed tomography can also do that by using computational fluid dynamics to calculate fractional
Sidhi Laksono Purwowiyoto
doaj   +1 more source

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