Gene Therapy for Cardiovascular Disease [PDF]
, 2003 The last decade has seen substantial advances in the development of gene therapy strategies and vector technology for the treatment of a diverse number of diseases, with a view to translating the successes observed in animal models into the clinic ...
Baker, Andrew H. +3 more
core +4 more sources
Impaired coronary blood flow at higher heart rates during atrial fibrillation: investigation via multiscale modelling [PDF]
Computer Methods and Programs in Biomedicine, 175: 95-102, 2019, 2019 Background. Different mechanisms have been proposed to relate atrial fibrillation (AF) and coronary flow impairment, even in absence of relevant coronary artery disease (CAD). However, the underlying hemodynamics remains unclear. Aim of the present work is to computationally explore whether and to what extent ventricular rate during AF affects the ...
arxiv +1 more source
How does diabetes cause coronary artery disease? [PDF]
, 1996 From the cardiologist’s viewpoint, diabetes increases the rate of development of coronary atheroma, increases the risk of a coronary thrombosis, and has a deleterious effect on the outcome of myocardial infarction.
De Bono, David
core
Biomarkers in acute coronary syndromes and their role in diabetic patients [PDF]
, 2005 Diabetic patients with acute coronary syndromes are at high risk for cardiovascular complications but risk stratification in these patients remains challenging.
Christopher Heeschen +5 more
core +1 more source
Lifetime cardiovascular management of patients with previous Kawasaki disease. [PDF]
, 2020 Kawasaki disease (KD) is an inflammatory disorder of young children, associated with vasculitis of the coronary arteries with subsequent aneurysm formation in up to one-third of untreated patients.
Brogan, Paul +14 more
core +1 more source
Outcomes Associated With Oral Anticoagulants Plus Antiplatelets in Patients With Newly Diagnosed Atrial Fibrillation. [PDF]
, 2020 Importance: Patients with nonvalvular atrial fibrillation at risk of stroke should receive oral anticoagulants (OAC). However, approximately 1 in 8 patients in the Global Anticoagulant Registry in the Field (GARFIELD-AF) registry are treated with ...
Bassand, J-P +17 more
core +2 more sources
Potentiation of thrombus instability: a contributory mechanism to the effectiveness of antithrombotic medications [PDF]
, 2018 © The Author(s) 2018The stability of an arterial thrombus, determined by its structure and ability to resist endogenous fibrinolysis, is a major determinant of the extent of infarction that results from coronary or cerebrovascular thrombosis.
A Gast +66 more
core +1 more source
Multi-scale simulation of thrombus formation at LVAD inlet cannula connection: Importance of Virchow's triad [PDF]
arXiv, 2020 As pump thrombosis is reduced in current-generation ventricular assist devices (VAD), adverse events such as bleeding or stroke remain at unacceptable rates. Thrombosis around the VAD inlet cannula (IC) has been highlighted as a possible source of stroke events.
arxiv
Vascular complications of cancer chemotherapy [PDF]
, 2015 Development of new anticancer drugs has resulted in improved mortality rates and 5-year survival rates in patients with cancer. However, many of the modern chemotherapies are associated with cardiovascular toxicities that increase cardiovascular risk in ...
Cameron, Alan C. +2 more
core +1 more source
Network-Based Approach for Modeling and Analyzing Coronary Angiography [PDF]
, 2019 Significant intra-observer and inter-observer variability in the interpretation of coronary angiograms are reported. This variability is in part due to the common practices that rely on performing visual inspections by specialists (e.g., the thickness of coronaries). Quantitative Coronary Angiography (QCA) approaches are emerging to minimize observer's
arxiv +1 more source