Results 111 to 120 of about 747,814 (341)

The outbreak of COVID-19 coronavirus and its impact on global mental health

International Journal of Social Psychiatry, 2020
Background: The current outbreak of COVID-19 coronavirus infection among humans in Wuhan (China) and its spreading around the globe is heavily impacting on the global health and mental health. Despite all resources employed to counteract the spreading of
J. Torales, M. O’Higgins, J. Castaldelli-Maia, A. Ventriglio   +3 more
semanticscholar   +1 more source

Advances in Single‐Cell Sequencing for Infectious Diseases: Progress and Perspectives

Advanced Science, EarlyView.
Single‐cell sequencing technologies uncover novel, unknown, and emergent features of many diseases. This review describes recent progress of single‐cell sequencing technologies and their applications in infectious diseases, summarizes the underlying commonalities of different infections and discusses future research directions, facilitating the ...
Mengyuan Lyu, Yang Liu, Jian Zhou, Hongli Lai, Hongxia Ruan, Dongsheng Wu, Shun Zhu, Xudong Zhou, Wananqi Ma, Yuchen Huang, Shuting Lei, Han Luo, Jie Chen, Binwu Ying   +13 more
wiley   +1 more source

COVID-19: UMA DURA SENTENÇA DE MORTE

Caderno de Administração, 2020
Não há como negar que vivemos tempos de aversão à velhice. Na medida em que valorizamos cada vez mais a eterna jovialidade, o lugar do velho na sociedade contemporânea é progressivamente diminuído, apagado.
Raquel de Oliveira Barreto, Alexandre de Pádua Carrieri   +1 more
doaj   +1 more source

Dual‐Locking the SARS‐CoV‐2 Spike Trimer: An Amphipathic Molecular “Bolt” Stabilizes Conserved Druggable Interfaces for Coronavirus Inhibition

Advanced Science, EarlyView.
A new amphipathic molecule, S416 is discovered, that locks the SARS‐CoV‐2 spike protein in its closed state, blocking viral entry. S416 acts as a molecular bolt, binding six sites: three between adjacent RBDs and three connecting NTDs to RBDs. This dual‐locking mechanism stiffens the spike structure and reduces its flexibility.
Shiliang Li, Fang Ye, Yucheng Zheng, Jie Wang, Haoran Peng, Lili Zhu, Lili Chen, Tao Yu, Huan Ge, Jiaqi He, Binghao Zhang, Jiayun Wu, Zhiyi Zhang, Liangliang Jiang, Geng Chen, Ping Zhao, Ke Lan, Zhenjiang Zhao, Xuhong Qian, Ke Xu, Yang Du, Honglin Li   +21 more
wiley   +1 more source

Hospitalization Rates and Characteristics of Patients Hospitalized with Laboratory-Confirmed Coronavirus Disease 2019 — COVID-NET, 14 States, March 1–30, 2020

MMWR. Morbidity and mortality weekly report, 2020
Since SARS-CoV-2, the novel coronavirus that causes coronavirus disease 2019 (COVID-19), was first detected in December 2019 (1), approximately 1.3 million cases have been reported worldwide (2), including approximately 330,000 in the United States (3 ...
S. Garg, L. Kim, M. Whitaker, A. O’Halloran, C. Cummings, R. Holstein, M. Prill, S. Chai, P. D. Kirley, N. Alden, B. Kawasaki, K. Yousey-Hindes, L. Niccolai, E. Anderson, K. Openo, A. Weigel, Maya L. Monroe, Patricia A. Ryan, Justin J. Henderson, Sue Kim, K. Como-Sabetti, R. Lynfield, D. Sosin, Salina M Torres, A. Muse, N. Bennett, L. Billing, M. Sutton, N. West, W. Schaffner, H. Talbot, C. Aquino, A. George, Alicia P. Budd, L. Brammer, G. Langley, A. Hall, A. Fry   +37 more
semanticscholar   +1 more source

NSP7 Molecular Degrader Attenuates Coronaviral Infection Through the β‐TrCP1/FBXO5 Axis

Advanced Science, EarlyView.
Host E3 ligase FBXO5 as a key regulator that promotes K48‐linked ubiquitination and proteasomal degradation of SARS‐CoV‐2 NSP7, thereby suppressing viral replication. NSP7 ubiquitination is co‐regulated by β‐TrCP1 and TAF1. Small molecule BC24877 disrupts β‐TrCP1‐mediated degradation of FBXO5, stabilizing FBXO5 and enhancing NSP7 clearance ...
Yao Tong, Travis B. Lear, Ferhan Tuncer, John J. Villandre, Áine N. Boudreau, Bo Lin, Irene Alfaras, Jason R. Kennerdell, Daniel P. Camarco, Mads B. Larsen, Yun Hua, Yanwen Chen, Meigin E. Chandler, Ricardo Pineda, Simon M. Barratt‐Boyes, John W. Evankovich, Toren Finkel, Yuan Liu, Bill B. Chen   +18 more
wiley   +1 more source

POLÍTICA PÚBLICA DA PREVIDÊNCIA SOCIAL E TRABALHADORES DA PESCA ARTESANAL: DILEMAS ESTRUTURAIS EM CONTEXTOS CONJUNTURAIS DO COVID-19

Revista Tamoios, 2020
A Lei Nº 13.982/2020, referente ao auxílio emergencial aos trabalhadores em condição de vulnerabilidade social foi sancionada pelo presidente da República em 02 de abril de 2020 como forma de manutenção das medidas de distanciamento social.
Catia Antonia da Silva, Karla da Silva Sampaio, Carolina Lourival Buch, Rodrigo Correa Euzêbio, Pedro Benício Almeida Pinto   +4 more
doaj   +1 more source

O vocabulário do coronavírus como meio de refletir o conhecimento sobre uma pessoa [PDF]

, 2022
The article examines the knowledge about a person that is represented by language units created during the coronavirus pandemic. These language units are formed using such methods as word-composition, affixation, substantiation, and blending and make up ...
Babina, Liudmila Vladimirovna
core   +1 more source

Potent Cross‐neutralizing Antibodies Reveal Vulnerabilities of Henipavirus Fusion Glycoprotein

Advanced Science, EarlyView.
Hendra and Nipah viruses (HNVs) pose significant threats to global health. This work reports potent cross‐neutralizing antibodies targeting the fusion glycoprotein (F) and reveals shared features of these antibodies and vulnerabilities of F, thereby guiding the rational design of countermeasures against HNVs and similar pathogens.
Yi Ren, Pengfei Fan, Xinghai Zhang, Ting Fang, Zhengshan Chen, Yanfeng Yao, Xiangyang Chi, Guanying Zhang, Xiaofan Zhao, Bingjie Sun, Fangxu Li, Zixuan Liu, Zhenwei Song, Baoyue Zhang, Cheng Peng, Entao Li, Yilong Yang, Jianmin Li, Sandra Chiu, Changming Yu   +19 more
wiley   +1 more source

Winter dysentery in cows associated with Bovine Coronavirus (BCoV) Disenteria de inverno associada ao coronavírus bovino (BCoV) em vacas

Arquivo Brasileiro de Medicina Veterinária e Zootecnia, 2007
Descreve-se a pesquisa de BCoV e rotavírus em 13 mostras fecais de vacas de surtos de disenteria utilizando uma nested PCR dirigida ao gene RdRp e PAGE, respectivamente.
P.E. Brandão, F. Gregori, A.J. Sforsin, L.Y.B. Villarreal, J.A. Jerez   +4 more
doaj   +1 more source