Results 91 to 100 of about 5,490,593 (301)

Inflammation Profiling of Critically Ill Coronavirus Disease 2019 Patients

Critical Care Explorations, 2020
Objectives:. Coronavirus disease 2019 is caused by severe acute respiratory syndrome-coronavirus-2 infection to which there is no community immunity. Patients admitted to ICUs have high mortality, with only supportive therapies available.
Douglas D. Fraser, MD, PhD, Gediminas Cepinskas, DVM, PhD, Marat Slessarev, MD, MSc, Claudio Martin, MD, MSc, Mark Daley, PhD, Michael R. Miller, PhD, David B. O’Gorman, PhD, Sean E. Gill, PhD, Eric K. Patterson, PhD, Claudia C. dos Santos, MD, MSc, on behalf of the Lawson COVID-19 Study Team, Robert Arntfield, Ian Ball, Gordon Barkwell, Tracey Bentall, Karen Bosma, Saoirse Cameron, Eileen Campbell, David Carter, Carolina Gillio-Meina, Robert Hegele, Natalya Odoardi, Ram Singh, Kelly Summers, Sue Tereschyn   +24 more
doaj   +1 more source

Decoding Viral Transmission Dynamics in Structured Populations Using a Microfluidic Herd‐Immunity‐on‐a‐Chip Platform

Advanced Science, EarlyView.
A microfluidic Herd‐Immunity‐on‐a‐Chip experimentally recreates structured contact networks to quantify viral transmission dynamics. By controlling susceptible, infected, and non‐susceptible populations, the platform reveals how contact topology governs the reproduction number, outbreak propagation, herd‐immunity–like behavior, and intervention ...
Jiande Zhang, Narina Jung, Min‐Hyeok Kim, Wanyoung Lim, Zhenzhong Chen, Byung Mook Weon, Sungsu Park   +6 more
wiley   +1 more source

Does Pulmonary Aspergillosis Complicate Coronavirus Disease 2019?

Critical Care Explorations, 2020
Objectives:. Aspergillus coinfection in coronavirus disease 2019 patients has rarely been described but may be occurring among coronavirus disease 2019 patients admitted to ICUs.
Karlyn D. Beer, MS, PhD, Brendan R. Jackson, MD, MPH, Tom Chiller, MD, MTMH, Paul E. Verweij, MD, PhD, Frank L. Van de Veerdonk, MD, PhD, Joost Wauters, MD, PhD   +5 more
doaj   +1 more source

An Engineered HR1‐Stem Helix‐HR2 Trimeric Platform for Developing Broad‐Spectrum Coronavirus Vaccines

Advanced Science, EarlyView.
Sun et al. report a self‐assembling trimeric subunit vaccine platform termed RHS, which integrates the JN.1 receptor‐binding domain (RBD) with the heptad repeat 1 (HR1), stem helix (SH), and heptad repeat 2 (HR2) regions. The SARS‐CoV‐2 RHS vaccine elicits variant‐reactive RBD‐specific antibodies and cross‐reactive SH‐specific antibodies against ...
Xikui Sun, Junhao Fan, Xiaolu Xie, Yuting Shi, Xiaoqing Liu, Tiefeng Xu, Sidi Yang, Keda Shi, Chengshu Xie, Shixiong Li, Siwen Chen, Ruoxi Cai, Ping He, Yuzhen Ye, Tao Chen, Xiancai Ma, Chunmei Li, Jingyou Yu, Deyin Guo   +18 more
wiley   +1 more source

Endothelial Injury and Glycocalyx Degradation in Critically Ill Coronavirus Disease 2019 Patients: Implications for Microvascular Platelet Aggregation

Critical Care Explorations, 2020
Objectives:. Coronavirus disease 2019 is caused by the novel severe acute respiratory syndrome coronavirus 2 virus. Patients admitted to the ICU suffer from microvascular thrombosis, which may contribute to mortality.
Douglas D. Fraser, MD, PhD, Eric K. Patterson, PhD, Marat Slessarev, MD, MSc, Sean E. Gill, PhD, Claudio Martin, MD, MSc, Mark Daley, PhD, Michael R. Miller, PhD, Maitray A. Patel, BSc, Claudia C. dos Santos, MD, MSc, Karen J. Bosma, MD, David B. O’Gorman, PhD, Gediminas Cepinskas, DVM, PhD, on behalf of the Lawson COVID19 Study Team, Robert Arntfield, Ian Ball, Gordon Barkwell, Tracey Bentall, Karen Bosma, Saoirse Cameron, Eileen Campbell, David Carter, Carolina Gillio-Meina, Robert Hegele, Natalya Odoardi, Ram Singh, Kelly Summers, Sue Tereschyn   +26 more
doaj   +1 more source

Niche‐Mediated Neural Priming Enables Robust and Scalable Generation of Human Choroid Plexus Organoids

Advanced Science, EarlyView.
Compared to E8, mTeSR1 culture downregulated WNT and TGF‑β signaling, and upregulated neural differentiation pathways, enhancing neural priming. Under skin organoid induction conditions, mTeSR1‑cultured hESCs generated organoids with significantly higher neuroepithelial differentiation.
Zhongliang Chen, Liangxia Jiang, Xianbin Wang, Lili Zhong, Rongcan Luo, Min Su, Liangzhao Chu, Peng Luo   +7 more
wiley   +1 more source

Coronavirus disease 2019 and pregnancy [PDF]

American Journal of Obstetrics and Gynecology, 2021
Rasmussen, Sonja A., Jamieson, Denise J.
openaire   +2 more sources

Site-specific alteration of murine hepatitis virus type 4 peplomer glycoprotein E2 results in reduced neurovirulence [PDF]

, 1986
Strains of the murine coronavirus mouse hepatitis virus type 4 (MHV-4) which contained a mutation in the E2 peplomer glycoprotein were obtained by selection for resistance to neutralization by monoclonal antibodies.
Lampert, P W, Dalziel, Robert, Buchmeier, M J, Talbot, Pierre J   +3 more
core  

A Dual‐Membrane Biomimetic Nanoplatform Enables Triple‐Modal Therapy Against SARS‐CoV‐2 Through Viral Decoy, Inflammation Neutralizing, and Intracellular RNAi

Advanced Science, EarlyView.
[A&T]MLN is a triple‐modal nanoplatform with siRNA‐loaded LN coated with hybrid ACE2/macrophage membrane. It blocks viral entry, neutralizes IL‐6/IL‐1β/TNF‐α, and delivers siRNA to suppress viral replication. In a murine lung injury model, it attenuates inflammation, offering a multi‐pronged strategy against SARS‐CoV‐2 variants and hyperinflammation ...
Hui Li, Bohan Zhang, Chao Shang, Yi Li, Te Zhao, Shengya Liu, Dan Liu, Junwei Che, Cuiling Zhang, Pinghui Wu, Wenjie Yang, Junjie Ding, Yuhua Ran, Yanan Zhai, Haihua Xiao, Jing Gao, Xiao Li, Chunsheng Gao, Lin Li, Zhiping Li   +19 more
wiley   +1 more source

Ezrin interacts with the SARS coronavirus spike protein and restrains infection at the entry stage [PDF]

, 2012
© 2012 Millet et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are ...
Béatrice Nal, Millet Jean Kaoru, Malik Peiris, Joseph S., Leung Hiu-Lan, Malik Peiris Joseph S., Siu, YL, Ralf Marius Altmeyer (117263), Siu, Y-L, Nal, B, Chan Wing-Lim, François Kien (117235), Hiu-Lan Leung, Leung, H-L, Yu-Lam Siu (117249), Altmeyer Ralf Marius, Siu Yu-Lam, Jaume, Martial, Martial Jaume, Chan, WL, Kien, F, Jaume, M, Kien François, Jean Kaoru Millet, Béatrice Nal (117269), Millet, Jean, K., Roberto Bruzzone, Millet, JK, Chan, Wing-Lim, Roberto Bruzzone (55052), Li, H, Altmeyer, RM, Millet, Jean Kaoru, Jean Kaoru Millet (117227), Wing-Lim Chan (117252), Bruzzone Roberto, Li Huiying, Hiu-Lan Leung (117257), Kien, François, Cheung, CY, Huiying Li (117255), Yu-Lam Siu, Cheung, Chung-Yan, Cheung Chung-Yan, Millet, Jean, Joseph S. Malik Peiris (117261), Altmeyer, Ralf Marius, Ralf Marius Altmeyer, Chan, W-L, Li, Huiying, Bruzzone, R, Wing-Lim Chan, François Kien, Chung-Yan Cheung, Cheung, C-Y, Bruzzone, Roberto, Leung, Hiu-Lan, Malik Peiris, Joseph S, Nal Béatrice, Siu, Yu-Lam, Jaume Martial, Peiris, JSM, Leung, HL, Nal, Béatrice, Martial Jaume (117259), Huiying Li, Joseph S Malik Peiris, Chung-Yan Cheung (117243)   +66 more
core   +1 more source