Results 71 to 80 of about 599,797 (262)

Arterial Blood‐Mediated Deep‐Tissue Photoacoustic Oximetry

Advanced Science, EarlyView.
The arterial prior method (APM+) for photoacoustic oximetry is introduced, which leverages the high arterial blood oxygenation to calibrate the fluence at the artery and estimate the oxygenation of the surrounding tissue, thus circumventing the spectral coloring problem. APM+’s accuracy and consistency are shown in a series of phantom and in vivo human
Karteekeya Sastry, Junhao Zhu, Joshua Olick‐Gibson, Li Lin, Lei Li, Jigmi Basumatary, Yang Zhang, Lihong V. Wang   +7 more
wiley   +1 more source

Site-specific alteration of murine hepatitis virus type 4 peplomer glycoprotein E2 results in reduced neurovirulence [PDF]

, 1986
Strains of the murine coronavirus mouse hepatitis virus type 4 (MHV-4) which contained a mutation in the E2 peplomer glycoprotein were obtained by selection for resistance to neutralization by monoclonal antibodies.
Lampert, P W, Dalziel, Robert, Buchmeier, M J, Talbot, Pierre J   +3 more
core  

Estimating the human health risk from possible BSE infection of the British sheep flock. [PDF]

, 2002
Following the controversial failure of a recent study and the small numbers of animals yet screened for infection, it remains uncertain whether bovine spongiform encephalopathy (BSE) was transmitted to sheep in the past via feed supplements and whether ...
T. J. Hagenaars, Donnelly, CA, Ghani, AC, Anderson, RM, Ferguson, NM, A. C. Ghani, Hagenaars, TJ, C. A. Donnelly, R. M. Anderson, N. M. Ferguson   +9 more
core   +1 more source

Respiratory syncytial virus (RSV) vaccine effectiveness and antibody correlates of protection among older adults in the Community Vaccine Effectiveness (CoVE) observational studyResearch in context

EBioMedicine
Summary: Background: The first RSV vaccines for adults 60 years and older were approved prior to the 2023–2024 respiratory virus season. This study aims to evaluate RSV vaccine effectiveness (VE) in preventing RSV infections among older adults, and to ...
Elie-Tino Godonou, Amy P. Callear, Casey L. Juntila-Raymond, Dolapo Raji, Matthew Smith, Kalee E. Rumfelt, Claire M. Midgley, Leora R. Feldstein, Jefferson M. Jones, Melissa Briggs Hagen, Marisa C. Eisenberg, Adam S. Lauring, Arnold S. Monto, Abram L. Wagner, Emily T. Martin   +14 more
doaj   +1 more source

Porcine Deltacoronavirus M Protein Binds NLRP3 to Promote Inflammasome Assembly via Competition with TRIM31

Advanced Science, EarlyView.
Porcine deltacoronavirus (PDCoV) infection induces severe intestinal inflammation and acute diarrhea in piglets, yet the molecular mechanism remains incompletely understood. The M protein activates NLRP3 inflammasome through dual mechanisms: direct binding to the NLRP3 LRR domain and disruption of TRIM31‐mediated K48‐linked ubiquitination.
Jinhui Hou, Fangfang Han, Anqi Liu, Yang Yu, Rui Zhao, Zhengting Shi, Yanrong Lv, Jinli Liu, Shaopo Zu, Zhanyong Wei, Jin Yuan, Hui Hu   +11 more
wiley   +1 more source

Implications of BSE infection screening data for the scale of the British BSE epidemic and current European infection levels. [PDF]

, 2002
The incidence of confirmed clinical cases of bovine spongiform encephalopathy (BSE) in Great Britain continues to decline, but the recent discovery of cases in previously unaffected countries (including Israel, Japan, Poland, Slovenia and Spain) has ...
Donnelly, Christl A, Ghani, Azra C, Anderson, Roy M, Ferguson, Neil M   +3 more
core   +1 more source

Does Pulmonary Aspergillosis Complicate Coronavirus Disease 2019?

Critical Care Explorations, 2020
Objectives:. Aspergillus coinfection in coronavirus disease 2019 patients has rarely been described but may be occurring among coronavirus disease 2019 patients admitted to ICUs.
Karlyn D. Beer, MS, PhD, Brendan R. Jackson, MD, MPH, Tom Chiller, MD, MTMH, Paul E. Verweij, MD, PhD, Frank L. Van de Veerdonk, MD, PhD, Joost Wauters, MD, PhD   +5 more
doaj   +1 more source

Somatic Evolution of a Germline Antibody Expands its Breadth to Neutralize Early SARS‐CoV‐2 Omicron Variants

Advanced Science, EarlyView.
Engineering of the 148‐germline (148‐GL) antibody reveals a roadmap for overcoming SARS‐CoV‐2 viral escape. By introducing four specific somatic hypermutations, the resulting 148‐M4 variant restores potent neutralization against Omicron BA.1 and BA.4/5.
Huibin Lv, Ziqi Feng, Qi Wen Teo, Chunke Chen, Akshita B. Gopal, Danbi Choi, Timothy J. C. Tan, Yun Sang Tang, Lewis Siu, Armita Nourmohammad, Roberto Bruzzone, Ian A. Wilson, Meng Yuan, Nicholas C. Wu, Chris K. P. Mok   +14 more
wiley   +1 more source

Coronavirus disease 2019 (COVID-19) [PDF]

Coronavirus Disease 2019 (COVID-19) 300x250Coronavirus-badge-300 ...

core  

Inflammation Profiling of Critically Ill Coronavirus Disease 2019 Patients

Critical Care Explorations, 2020
Objectives:. Coronavirus disease 2019 is caused by severe acute respiratory syndrome-coronavirus-2 infection to which there is no community immunity. Patients admitted to ICUs have high mortality, with only supportive therapies available.
Douglas D. Fraser, MD, PhD, Gediminas Cepinskas, DVM, PhD, Marat Slessarev, MD, MSc, Claudio Martin, MD, MSc, Mark Daley, PhD, Michael R. Miller, PhD, David B. O’Gorman, PhD, Sean E. Gill, PhD, Eric K. Patterson, PhD, Claudia C. dos Santos, MD, MSc, on behalf of the Lawson COVID-19 Study Team, Robert Arntfield, Ian Ball, Gordon Barkwell, Tracey Bentall, Karen Bosma, Saoirse Cameron, Eileen Campbell, David Carter, Carolina Gillio-Meina, Robert Hegele, Natalya Odoardi, Ram Singh, Kelly Summers, Sue Tereschyn   +24 more
doaj   +1 more source