Results 61 to 70 of about 599,797 (262)

ZDHHC18‐Mediated Palmitoylation of ORF3a Promotes SARS‐CoV‐2 Pathogenesis by Antagonizing TRIM16‐Mediated Ubiquitination and Proteasomal Degradation

Advanced Science, EarlyView.
Palmitoylation by ZDHHC18 blocks ORF3a K27‐linked ubiquitination mediated by TRIM16, thereby preventing its proteasomal degradation and strengthening viral pathogenesis. Targeting palmitoylation through a pharmacological inhibitor (2‐BP), a competitive inhibitory peptide (OPIP), or adenovirus‐mediated knockdown of ZDHHC18 expression presents a ...
Sidi Yang, Kun Li, Lihong Liu, Linsen Zeng, Qifeng Deng, Jiacheng Huang, Xiaoran Dong, Xin Wang, Jianwei Liang, Hongchao Liu, Hong Peng, Yuxin Lin, Xiaolu Xie, Yuzhen Ye, Tiefeng Xu, Zhaohuan Wang, Chun‐Mei Li, Deyin Guo   +17 more
wiley   +1 more source

Mortality and progression to AIDS after starting highly active antiretroviral therapy. [PDF]

, 2003
OBJECTIVES: To examine survival and progression to AIDS among HIV-infected patients after starting highly active antiretroviral therapy (HAART). METHODS: The study population consisted of 3724 patients from the ATHENA observational cohort who initiated ...
de Wolf, Frank, Lange, JMA, van Sighem, A.I., Ghani, Azra C, Reiss, Peter, Lange, J.M.A., Lange, Joep MA, van de Wiel, Mark A, Sighem, van, A.I., Wolf, de, F., Gyssens, ICJ (Inge), Ghani, A.C., Ghani, AC, Gyssens, I.C., de Lange, J., van Sighem, Ard I, Gyssens, Inge C, Jambroes, M, Jambroes, M., Wiel, MA Mark van de, Wolf, F de, de Wolf, F, Brinkman, K., Wiel, van de, M.A., Sighem, AI van, Reiss, P, Sighem, AI, Brinkman, K, ATHENA Cohort Study Group, Jambroes, Mariëlle, Brinkman, Kees, de Wolf, F., Gyssens, IC, van de Wiel, M.A., van de Wiel, MA, Reiss, P.   +35 more
core   +1 more source

Longitudinal analysis of SARS-CoV-2 IgG antibody durability in Puerto Rico

Scientific Reports
Understanding the dynamics of antibody responses following vaccination and SARS-CoV-2 infection is important for informing effective vaccination strategies and other public health interventions.
Zachary J. Madewell, Nathan E. Graff, Velma K. Lopez, Dania M. Rodriguez, Joshua M. Wong, Panagiotis Maniatis, Freddy A. Medina, Jorge L. Muñoz, Melissa Briggs-Hagen, Laura E. Adams, Vanessa Rivera-Amill, Gabriela Paz-Bailey, Chelsea G. Major   +12 more
doaj   +1 more source

DMS‐MaPseq and DREEM Analyses Implicate the Critical Role of RNA Structural Dynamics in Turnip Yellow Mosaic Virus Pathogenicity

Advanced Science, EarlyView.
RNA structural profiling of Turnip Yellow Mosaic Virus by DMS‐MaPseq and DREEM analyses uncover that viral genome‐wide RSS is highly complicated and heterogeneous, with alternative RSSs widely distributed across the genome. Notably, the viral 3’ tRNA‐like structure adopts alternative conformations in vivo.
Jiaying Zhu, Changhao Li, Chisimbily Onyia, Xindi Li, Xingxing Yan, Songxiao Zhong, Taerin Oh, Xiuren Zhang   +7 more
wiley   +1 more source

Comparison of the risks of atherosclerotic events versus death from other causes associated with antiretroviral use. [PDF]

, 2006
BACKGROUND: Studies considering the risk of atherosclerotic disease (AtD) associated with the use of HAART have reported inconsistent results. METHODS: Data on antiretroviral therapy (ART) use, risk factors for cardiovascular disease (CVD), AtD and death
de Wolf, Frank, Kwong, Grace PS, Ghani, Azra C, Cameron, D William, da Silva, Barbara, Cowling, Benjamin J., Danner, Sven A., Cameron, D. William, De Wolf, F, Ghani, AC, Anderson, RM, Bartley, Lucy M, van Sighem, Ard I, Bartley, LM, Kwong, GPS, Cowling, Benjamin J, Van Sighem, AI, Danner, SA, Donnelly, CA, Donnelly, Christl A., Ghani, Azra C., Anderson, Roy M, Danner, Sven A, Rode, Richard A, Rode, Richard A., Donnelly, Christl A, Da Silva, B, Bartley, Lucy M., Cowling, BJ, Cameron, DW, Van Sighem, Ard I., Rode, RA, Kwong, Grace P.S., Anderson, Roy M.   +33 more
core   +1 more source

A review of novel coronavirus infection (Coronavirus Disease-19)

Global Journal of Transfusion Medicine, 2020
Coronavirus (CoV) disease-2019 (COVID-19) is an infectious disease caused by the severe acute respiratory syndrome-CoV-2. The disease started in 2019 in Wuhan, China, and has spread globally, resulting in a pandemic. Common symptoms include fever, cough,
Neelesh Jain, Animesh Choudhury, Jayesh Sharma, Venkata Kumar, Divyendu De, Richa Tiwari   +5 more
doaj   +1 more source

RNA‐Binding Protein RBM25 Targets the mRNA Stability of GTPase Rab22a to Restrict Viral Entry and Infection

Advanced Science, EarlyView.
This study identifies RNA‐binding protein RBM25 as a broad‐spectrum antiviral factor acting independently of type I interferon. It blocks viral entry by suppressing GTPase Rab22a via the RC3H1‐mediated destabilization of Rab22a mRNA. Viral downregulation of RBM25 enhances GTPase Rab22a expression and viral entry, revealing an unreported post ...
Yingying Ding, Huiying Chen, Yuyu Jiang, Chunyan Zhao, Jie Bai, Yan Xiang, Zeting Wang, Xixi Wang, Bing Rui, Wanda Tang, Yue Ding, Zhenzhen Zhan, Yunkai Zhang, Xingguang Liu   +13 more
wiley   +1 more source

Clinical and laboratory characteristics of patients hospitalized with severe COVID-19 in New Orleans, August 2020 to September 2021

Scientific Reports
Louisiana experienced high morbidity and mortality from COVID-19. To assess possible explanatory factors, we conducted a cohort study (ClinSeqSer) of patients hospitalized with COVID-19 in New Orleans during August 2020–September 2021.
Arnaud Drouin, Ian D. Plumb, Matthew McCullough, Jade James Gist, Sharon Liu, Marc Theberge, Joshua Katz, Matthew Moreida, Shelby Flaherty, Bhoomija Chatwani, Melissa Briggs Hagen, Claire M. Midgley, Dahlene Fusco   +12 more
doaj   +1 more source

Novel Outcome Biomarkers Identified With Targeted Proteomic Analyses of Plasma From Critically Ill Coronavirus Disease 2019 Patients

Critical Care Explorations, 2020
Objectives:. Coronavirus disease 2019 patients admitted to the ICU have high mortality. The host response to coronavirus disease 2019 has only been partially elucidated, and prognostic biomarkers have not been identified. We performed targeted proteomics
Douglas D. Fraser, MD, PhD, Gediminas Cepinskas, DVM, PhD, Eric K. Patterson, PhD, Marat Slessarev, MD, MSc, Claudio Martin, MD, MSc, Mark Daley, PhD, Maitray A. Patel, BSc, Michael R. Miller, PhD, David B. O’Gorman, PhD, Sean E. Gill, PhD, Guillaume Pare, MD, MSc, Ioannis Prassas, PhD, Eleftherios Diamandis, MD, PhD, on behalf of the Lawson COVID19 Study Team, Robert Arntfield, Ian Ball, Gordon Barkwell, Tracey Bentall, Karen Bosma, Saoirse Cameron, Eileen Campbell, David Carter, Carolina Gillio-Meina, Robert Hegele, Natalya Odoardi, Ram Singh, Kelly Summers, Sue Tereschyn   +27 more
doaj   +1 more source

S100A8/A9‐High Macrophages Activate Intestinal Fibroblasts via mCCL6/hCCL15‐CCR1 Axis to Drive Intestinal Fibrosis in Crohn's Disease

Advanced Science, EarlyView.
S100A8/A9‐high macrophages are markedly enriched in the stenotic intestinal tissue of patients with Crohn's disease. These profibrotic macrophages secrete mCCL6 in a STAT3‐dependent manner. mCCL6 and its human ortholog hCCL15 activate fibroblasts via the CCR1 receptor, thereby driving excessive collagen deposition.
Shu Wang, Jiayun Wang, Junjie Lin, Ziping Ye, Geyujia Zhou, Jingjing Ma, Junjian Sun, Jiang Yu, Yingdi Zhang, Nana Tang, Chunhua Jiao, Xiaojing Zhao, Hongjie Zhang   +12 more
wiley   +1 more source