Results 111 to 120 of about 3,857,996 (335)

Extracellular Vesicle‐Delivered tRF‐His‐GTG‐1 Reprograms Neutrophil Lipophagy and Triggers Inflammation in COVID‐19

Advanced Science, EarlyView.
This study identifies platelet‐derived extracellular vesicles as key immunometabolic regulators in COVID‐19. The delivery of tRF‐His‐GTG‐1 to neutrophils activates TLR8mTOR signaling, disrupts lipophagy, and amplifies NET‐mediated inflammation. Importantly, targeting this axis restores neutrophil homeostasis, offering a potential therapeutic strategy ...
Tsai‐Ling Liao, Po‐Yu Liu, Yi‐Ming Chen, Kuo‐Tung Tang, Hung‐Jen Liu, Der‐Yuan Chen   +5 more
wiley   +1 more source

Singing Is a Risk Factor for Severe Acute Respiratory Syndrome Coronavirus 2 Infection: A Case-Control Study of Karaoke-Related Coronavirus Disease 2019 Outbreaks in 2 Cities in Hokkaido, Japan, Linked by Whole Genome Analysis [PDF]

, 2022
Manami Nakashita, Yuta Takagi, Hiroyuki Tanaka, Haruna Nakamura, Yusuke Serizawa, Tomohiko Ukai, Kotaro Azuma, Hiroko Chiba, Kensaku Terada, Kaori Nakanishi, Tomoko Fujikawa, Kayoko Saito, Ryo Yamaguchi, Yuu Mitsuhashi, Koichi Yano, Tomoko Shibuma, Akemi Kuzuma, Shinichiro Tsuda, Terukazu Sadamoto, Yasuhiko Ishii, Tsukasa Ohara, Yoshiaki Hitomi, Takashi Hiroshima, Takuya Yamagishi, Hajime Kamiya, Anita Samuel, Yuichiro Yahata, Tomoe Shimada, Yuzo Arima, Motoi Suzuki, Tsuyoshi Sekizuka, Makoto Kuroda, Tomimasa Sunagawa   +32 more
openalex   +1 more source

Bacterial and fungal co-infection in individuals with coronavirus: A rapid review to support COVID-19 antimicrobial prescribing

Clinical Infectious Diseases, 2020
Background To explore and describe the current literature surrounding bacterial/fungal co-infection in patients with coronavirus infection. Methods MEDLINE, EMBASE, and Web of Science were searched using broad based search criteria relating to ...
T. Rawson, Luke S.P. Moore, N. Zhu, Nisha Ranganathan, K. Skolimowska, M. Gilchrist, G. Satta, G. Cooke, A. Holmes   +8 more
semanticscholar   +1 more source

A Lung‐Immune Dual‐Humanized Mouse Using Cryopreserved Tissue Enables Infection and Immune Profiling of Human Common Cold Coronaviruses

Advanced Science, EarlyView.
Cryopreserved lung‐humanized mice overcome the dependency to fresh tissues and permit head‐to‐head profiling of all four human common cold coronaviruses versus SARS‐CoV‐2 infection; the model validates Paxlovid efficacy against HKU1 and, when coupled with human immune‐system engraftment, enables interrogation of lung‐resident human immunity and HKU1 ...
Chunyu Cheng, Jing Sun, Chun Lu, Qian Yu, Yiyun He, Bingqing Wu, Deshan Ren, Shuai Ding, Jincun Zhao, Yan Li   +9 more
wiley   +1 more source

Structure‐Based Development of Ultra‐Broad‐Spectrum 3C‐Like Protease Inhibitors

Advanced Science, EarlyView.
This study provides an in‐depth analysis of the substrate binding pocket of 3CLpros across all coronavirus species using bioinformatics and structural insights, revealing the critical impact of S2/S4 subsite diversity on the broad‐spectrum activity of approved therapeutics.
Haixia Su, Tianqing Nie, Guofeng Chen, Muya Xiong, Yumin Zhang, Guoqing Wu, Mengyuan You, Hang Xie, Jian He, Yanchao Xiong, Hangchen Hu, Wenfeng Zhao, Minjun Li, Gengfu Xiao, Leike Zhang, Yechun Xu   +15 more
wiley   +1 more source

ECG changes after rabbit coronavirus infection

Journal of Electrocardiology, 1999
This study examines the electrocardiographic (ECG) changes following rabbit coronavirus (RbCV) infection. We have shown that infection with RbCV results in the development of myocarditis and congestive heart failure and that some survivors of RbCV infection go on to develop dilated cardiomyopathy in the chronic phase.
Alexander, Lorraine K., Keene, Bruce W., Yount, Boyd L., Geratz, Joachim Dieter, Small, J.David, Baric, Ralph S.   +5 more
openaire   +2 more sources

A Modular Vaccine Platform Against SARS‐CoV‐2 Based on Self‐Assembled Protein Nanoparticles

Advanced Science, EarlyView.
A modular BP26 nanoparticle vaccine platform incorporating the SpyTag/SpyCatcher system enables high‐density, repetitive antigen display with post‐expression flexibility. Conjugation of the SARS‐CoV‐2 RBD to BP26 nanoparticles elicits strong humoral immunity and confers protection against viral challenge in vivo.
Seojung Lee, Yejin Jang, Yujin Kim, Yumi Shin, Ji‐Joon Song, Meehyein Kim, Sangyong Jon   +6 more
wiley   +1 more source

Mathematical modeling of the spread of the coronavirus under strict social restrictions

Mathematical Methods in the Applied Sciences, EarlyView., 2021
We formulate a simple susceptible‐infectious‐recovery (SIR) model to describe the spread of the coronavirus under strict social restrictions. The transmission rate in this model is exponentially decreasing with time. We find a formula for basic reproduction function and estimate the maximum number of daily infected individuals.
Mo'tassem Al‐arydah, Hailay Berhe, Khalid Dib, Kalyanasundaram Madhu   +3 more
wiley   +1 more source

Lactoferrin as Protective Natural Barrier of Respiratory and Intestinal Mucosa against Coronavirus Infection and Inflammation

International Journal of Molecular Sciences, 2020
Recently, the world has been dealing with a devastating global pandemic coronavirus infection, with more than 12 million infected worldwide and over 300,000 deaths as of May 15th 2020, related to a novel coronavirus (2019-nCoV), characterized by a ...
E. Campione, Terenzio Cosio, L. Rosa, C. Lanna, S. Di Girolamo, R. Gaziano, P. Valenti, L. Bianchi   +7 more
semanticscholar   +1 more source

Effects of Coronavirus Infections in Children

Emerging Infectious Diseases, 2010
The isolation of the coronavirus (CoV) identified as the cause of severe acute respiratory syndrome and the detection of 2 new human CoVs (HCoV-NL63 and HCoV-HKU1) have led to studies of the epidemiology and clinical and socioeconomic effects of infections caused by all HCoVs, including those known since the late 1960s (HCoV-229E and HCoV-OC43).
N. Principi, S. Bosis, S. Esposito
openaire   +4 more sources