Results 241 to 250 of about 625,035 (300)

SARS‐CoV‐2 nucleocapsid protein variants have differential RNA chaperone activity

The FEBS Journal, EarlyView.
The SARS‐CoV‐2 nucleocapsid (N) protein facilitates RNA annealing through its RBD–IDR2–CTD region, identifying it as a functional RNA chaperone. The Omicron BA.5 variant shows reduced chaperone activity compared to the Wuhan wild‐type protein. Although phosphorylation has no effect on wild‐type N, phosphomimetic modification of BA.5 N restores its RNA ...
Sabrina Babl, Julia M. Seidel, Fabian Kugler, Elisabeth Silberhorn, Anna Ludwig, Jonas Abel, Sophia Winklbauer, Niklas Schaub, Silvia Materna‐Reichelt, Kamran Honarnejad, Nataša Stojanović Gužvić, Gernot Längst   +11 more
wiley   +1 more source

Impact of perceived factors of coronavirus infection on COVID-19 vaccine uptake among healthcare workers in Ghana-Evidence from a cross-sectional analysis. [PDF]

PLoS One
Gelyi EK, Azaare J, Bonso NK, Kpordoxah MR, Aninanya GA.   +4 more
europepmc   +1 more source

Degradomics for large‐scale mechanistic insights on proteases and proteolysis in human health

The FEBS Journal, EarlyView.
Proteolysis has an important role in human disease but remains relatively unexplored. Degradomics, the uncovering of proteolysis in tissues, cells, and proteins, uses mass spectrometry‐based terminomics to identify protein termini occurring therein (forward degradomics) and to define the actions of proteases (reverse degradomics).
Daniel R. Martin, Sumit Bhutada, Suneel S. Apte   +2 more
wiley   +1 more source

Fatal consequences of feline coronavirus infection are associated with virus persistence and a distinct adaptive immune repertoire

Hiron TK, Falcone S, The MASCOT Consortium, Kipar A, Hezzell MJ, O’Callaghan CA, Barker EN, Davison LJ.   +7 more
europepmc   +1 more source

CD6 regulates CD4 T follicular helper cell differentiation and humoral immunity during murine coronavirus infection. [PDF]

J Virol
Cardani-Boulton A, Lin F, Bergmann CC.
europepmc   +1 more source

Reversible cerebral vasoconstriction syndrome: A narrative review

Headache: The Journal of Head and Face Pain, EarlyView.
Abstract Objectives/Background This review summarizes current insights into Reversible cerebral vasoconstriction syndrome (RCVS) diagnosis, management, and outcomes. RCVS is a cerebrovascular disorder characterized by recurrent thunderclap headaches and transient segmental vasoconstriction of cerebral arteries, typically resolving within 3 months ...
Ícaro Araújo de Sousa, Abner da Silva Machado, Arthur de Oliveira Veras, Thiago Oscar Goulart, Sarah Galassi Tatsuta, Trajano Aguiar Pires Gonçalves, Eva Rocha, Octávio Marques Pontes‐Neto   +7 more
wiley   +1 more source

Wuzhishan miniature pig-derived intestinal 2D monolayer organoids to investigate the enteric coronavirus infection. [PDF]

Front Vet Sci
Liu Y, Yang N, Tan C, Zhang Y, Gao S, Cai Y, Zhang Y, Fu Y, Liu G, Li Y.   +9 more
europepmc   +1 more source

The role of peripheral serotonin in SARS‐CoV‐2 infectivity, COVID‐19 treatment and long COVID

Immunology &Cell Biology, EarlyView.
In this article, we discuss how SARS‐CoV‐2 infects the gastrointestinal tract, that enterochromaffin cells, the source of circulating serotonin, uniquely express viral entry receptors. We examine how this infection disrupts gut‐derived serotonin, contributing to gastrointestinal symptoms and disease severity, and link elevated plasma serotonin to COVID‐
Daniel W Thorpe, Lauren A Jones, Alyce M Martin, Rosemary A Coleman, Caitlin Allman, Rochelle A Peterson, Damien J Keating   +6 more
wiley   +1 more source

Efficacy of a novel antigen-decorated adenoviral vaccine platform against porcine respiratory coronavirus infection in a large natural host

Wongborphid S, Briggs EJ, Russell RA, Chowdhury S, Vats A, Charlton BG, Rose LM, D'Agostino R, Bowman LAH, Rollier C, Hatton CF, Sadeyen J, Iqbal M, Moorhouse E, Cayol T, Bickerton E, Munir D, Salguero FJ, Paudyal B, Keep S, Biswas S, Dicks MDJ, Tchilian E.   +22 more
europepmc   +1 more source

Insights into the Activation of Unfolded Protein Response Mechanism during Coronavirus Infection. [PDF]

Curr Issues Mol Biol
Keramidas P, Pitou M, Papachristou E, Choli-Papadopoulou T.   +3 more
europepmc   +1 more source