Results 81 to 90 of about 468,607 (303)

Cerebral venous thrombosis in a patient with Down syndrome and coronavirus disease 2019: a case report

Journal of Medical Case Reports, 2021
Background The new coronavirus disease 2019 pandemic has spread throughout most of the world. Cerebral venous thrombosis is a rare thromboembolic disease that can present as an extrapulmonary complication in coronavirus disease 2019 infection.
Henry Robayo-Amortegui, Natalia Valenzuela-Faccini, Cesar Quecano-Rosas, Darlyng Zabala-Muñoz, Michel Perez-Garzon   +4 more
doaj   +1 more source

Projections of the future course of the primary vCJD epidemic in the UK: inclusion of subclinical infection and the possibility of wider genetic susceptibility

, 2005
The incidence of variant Creutzfeldt–Jakob disease (vCJD) in the United Kingdom appears to be in decline, with only four deaths reported this year (to 6 September 2004).
Ghani, Azra C, Clarke, Paul
core   +1 more source

Secreted Nonstructural Protein 3 is a Pathogenic Determinant of Orbivirus

Advanced Science, EarlyView.
This study uncovers a conserved PIP2‐dependent secretory pathway of orbivirus NS3 that induces vascular leakage. Pharmacological disruption of PIP2‐NS3 interaction significantly reduces viral pathogenicity and provides protective efficacy in murine models, establishing PIP2‐mediated NS3 secretion as both a key virulence determinant and a promising ...
Junyong Guan, Dong Zhou, Ran Shao, Xing Liu, Jin Peng, Yingran Huang, Shuhui Qi, Cankun Xi, Menghang Wang, Bin Sun, Yinglin Qi, Xin Yin   +11 more
wiley   +1 more source

ZDHHC18‐Mediated Palmitoylation of ORF3a Promotes SARS‐CoV‐2 Pathogenesis by Antagonizing TRIM16‐Mediated Ubiquitination and Proteasomal Degradation

Advanced Science, EarlyView.
Palmitoylation by ZDHHC18 blocks ORF3a K27‐linked ubiquitination mediated by TRIM16, thereby preventing its proteasomal degradation and strengthening viral pathogenesis. Targeting palmitoylation through a pharmacological inhibitor (2‐BP), a competitive inhibitory peptide (OPIP), or adenovirus‐mediated knockdown of ZDHHC18 expression presents a ...
Sidi Yang, Kun Li, Lihong Liu, Linsen Zeng, Qifeng Deng, Jiacheng Huang, Xiaoran Dong, Xin Wang, Jianwei Liang, Hongchao Liu, Hong Peng, Yuxin Lin, Xiaolu Xie, Yuzhen Ye, Tiefeng Xu, Zhaohuan Wang, Chun‐Mei Li, Deyin Guo   +17 more
wiley   +1 more source

Review and Thinking on Forensic Pathological Changes of Coronavirus-Infected Diseases

Fayixue Zazhi, 2021
Since the beginning of this century, three types of coronavirus have widely transmitted and caused severe diseases and deaths, which strongly indicates that severe infectious diseases caused by coronavirus infection are not accidental events. Coronavirus-
ZHOU Nan, ZHAO Qian-hao, ZHENG Jing-jing, MAO Dan-mi, ZHENG Da, HU Bing-jie, CHENG Jian-ding   +6 more
doaj   +1 more source

The epidemiology of variant Creutzfeldt-Jakob disease

, 2002
Variant Creutzfeldt-Jakob disease (vCJD) was identified as a new disease in 1996. It was linked to infection with the bovine spongiform encephalopathy (BSE) agent although the epidemiological evidence for this was not strong, but later strain typing ...
d' Huillard Aignaux, JN, S. N. Cousens, P. G. Smith, Smith, PG, J. N. Huillard d’Aignaux, Ghani, AC, Azra C. Ghani, Ward, HJT, R. G. Will, Cousens, SN, Will, RG, Huillard d'Aignaux, JN, H. J. T. Ward   +12 more
core   +1 more source

The M, E, and N structural proteins of the severe acute respiratory syndrome coronavirus are required for efficient assembly, trafficking, and release of virus-like particles [PDF]

, 2008
Copyright @ 2008 American Society for Microbiology.The production of virus-like particles (VLPs) constitutes a relevant and safe model to study molecular determinants of virion egress.
Kien, F., Nicholls, JM, Bruzzone, R, Chan, C. M., Tsao, SW, Kien, F, Siu, Y. L., Escriou, N, Altmeyer, R., Nal, B., Nicholls, J. M., Chan, CM, Siu, YL, Lo, J, Peiris, J. S. M., Tsao, S. W., Teoh, KT, Nal, B, Teoh, K. T., Peiris, JSM, Altmeyer, R, Lo, J., Escriou, N., Bruzzone, R.   +23 more
core   +1 more source

Orofacial pain during the new coronavirus infection (COVID-19) pandemic

, 2022
Doctors of various specialties face orofacial pain in their practice: dentists, maxillofacial surgeons, neurologists, otorhinolaryngologists, therapists, traumatologists, ophthalmologists, psychotherapists, physiotherapists, aesthetic medicine doctors ...
Dmitry I. Trukhan, Larisa Yu. Trukhan, Anatoly F. Sulimov, Igor N. Stepanov, Innokenty S. Chusov   +4 more
core   +1 more source

DMS‐MaPseq and DREEM Analyses Implicate the Critical Role of RNA Structural Dynamics in Turnip Yellow Mosaic Virus Pathogenicity

Advanced Science, EarlyView.
RNA structural profiling of Turnip Yellow Mosaic Virus by DMS‐MaPseq and DREEM analyses uncover that viral genome‐wide RSS is highly complicated and heterogeneous, with alternative RSSs widely distributed across the genome. Notably, the viral 3’ tRNA‐like structure adopts alternative conformations in vivo.
Jiaying Zhu, Changhao Li, Chisimbily Onyia, Xindi Li, Xingxing Yan, Songxiao Zhong, Taerin Oh, Xiuren Zhang   +7 more
wiley   +1 more source

Clinical course and outcome of 107 patients infected with the novel coronavirus, SARS-CoV-2, discharged from two hospitals in Wuhan, China

Critical Care, 2020
Background In December 2019, coronavirus disease 2019 (COVID-19) outbreak was reported from Wuhan, China. Information on the clinical course and prognosis of COVID-19 was not thoroughly described.
Dawei Wang, Yimei Yin, Chang Hu, Xing Liu, Xingguo Zhang, Shuliang Zhou, Mingzhi Jian, Haibo Xu, John Prowle, Bo Hu, Yirong Li, Zhiyong Peng   +11 more
doaj   +1 more source