Results 151 to 160 of about 482,781 (345)

Structure‐Based Rational Design of a Selective Hydrolase Inhibitor of the Severe Acute Respiratory Syndrome Coronavirus‐2 Nsp3 Macrodomain

ChemBioChem, EarlyView.
Structure‐guided design of a sulfamoyl‐modified analog of GS‐441524 yielded a selective, high‐affinity inhibitor of the SARS‐CoV‐2 macrodomain Nsp3b. The compound occupies the phosphate‐binding pocket, forming a stabilizing hydrogen‐bond network that enhances binding affinity (K_D = 0.86 μM).
Robin Krishnathas, Konstantin S. Mineev, Nikolaos K. Fourkiotis, Franck Touret, Christos Sideras‐Bisdekis, Aikaterini C. Tsika, Santosh Lakshmi Gande, Verena Linhard, Sridhar Sreeramulu, Frank Lennartz, Manfred S. Weiss, Bruno Coutard, Georgios A. Spyroulias, Harald Schwalbe   +13 more
wiley   +1 more source

Electrochemical Detection of SARS‐CoV‐2 in Saliva Using ZnO Nanorods Functionalized with Gold‐Conjugated Antireceptor‐Binding Domain Antibodies

ChemNanoMat, EarlyView.
An electrochemical immunosensor based on ZnO nanorods functionalized with gold nanoparticle‐conjugated anti‐receptor‐binding domain antibodies enables rapid, noninvasive, and selective detection of SARS‐CoV‐2 in saliva, providing a promising platform for point‐of‐care diagnostic applications.
Fabíola Lelis de Castro, Ana Cristina Honorato Castro‐Kochi, Marcos Roberto de Araújo Silva, Priscila Sabbag Ferreira, Sydney Ferreira Santos, Lídia Maria de Andrade, Mariano Venanzi, Francesca Cavalieri, Mariângela de Oliveira Silva, Isabela Pazotti Daher, Catarina Harumi Oda Ibrahim, Vivian Leite de Oliveira, Jorge Kalil, Tamires Lopes Silva, Silvia Beatriz Boscardin, Wendel Andrade Alves   +15 more
wiley   +1 more source

Safety and Pharmacokinetics of Long‐Acting Monoclonal Antibodies Tixagevimab and Cilgavimab (AZD7442) in a China Phase 2 Study and Evaluation of Asian Race Effect

Clinical Pharmacology in Drug Development, EarlyView.
Abstract Safety, pharmacokinetics, and impact of race of pharmacokinetics on monoclonal antibodies tixagevimab and cilgavimab (AZD7442) were assessed in Chinese adult participants in a Phase 2, randomized, double‐blind, placebo‐controlled trial. In total, 272 participants were randomized 3:1 to a single intravenous dose of 600 mg AZD7442 or placebo and
Jing Zhang, Huixia Zhang, Yajuan Zhang, Shuyuan Liu, Xiaoyun Ge, Haiyue Zhang, Yunfei Li, Cecil Chi‐Keung Chen, Oleg Stepanov, Weifeng Tang, Wenhong Zhang   +10 more
wiley   +1 more source

Mathematical modeling of the spread of the coronavirus under strict social restrictions

Mathematical Methods in the Applied Sciences, EarlyView., 2021
We formulate a simple susceptible‐infectious‐recovery (SIR) model to describe the spread of the coronavirus under strict social restrictions. The transmission rate in this model is exponentially decreasing with time. We find a formula for basic reproduction function and estimate the maximum number of daily infected individuals.
Mo'tassem Al‐arydah, Hailay Berhe, Khalid Dib, Kalyanasundaram Madhu   +3 more
wiley   +1 more source

Approbation of the Technology for Constructing Means of Express Indication of New Especially Dangerous

Вестник войск РХБ защиты
Catastrophic pandemic of the particularly dangerous coronavirus SARS-CoV-2 in 2020–2022 and the unexpected  spread of the monkeypox pathogen from Africa in 2022, demonstrate the need for an adequate response to biological  threats that have exotic ...
A. A. Petrov, A. V. Kazantsev, K. A. Panferov, A. A. Chislov, E. A. Kovalchuk, D. A. Kutaev, S. V. Borisevich   +6 more
doaj   +1 more source

A translation-attenuating intraleader open reading frame is selected on coronavirus mRNAs during persistent infection. [PDF]

, 1993
Martin Hofmann‐Apitius, Savithra D. Senanayake, David A. Brian   +2 more
openalex   +1 more source

Evolving Real‐World Data and Evidence Use for New Drugs and Regenerative Medical Products Approvals in Japan—An Analysis of the 6‐Year Trend

Clinical Pharmacology &Therapeutics, EarlyView.
Several regulatory initiatives have been made to clarify the acceptability and requirements of real‐world data and real‐world evidence (RWD/E) for the benefit/risk assessment of new medical products in Japan. The objectives of this review were to characterize the use of RWD/E in regulatory applications of new medical products and to describe the ...
Suguru Okami, Kako Shimotsumagari, Yasunari Sadatsuki   +2 more
wiley   +1 more source

An Experimental Model for Dilated Cardiomyopathy after Rabbit Coronavirus Infection [PDF]

, 1992
Lorraine K. Alexander, J. David Small, Sue Edwards, Ralph S. Baric   +3 more
openalex   +1 more source

Proviral role of caspase-6 in coronavirus infections. [PDF]

Cell Res, 2023
Wong LR, Perlman S.
europepmc   +1 more source

Simultaneous vaccination against influenza and respiratory syncytial virus in high‐risk heart failure patients

ESC Heart Failure, EarlyView.
In a prospective, randomized study of high‐risk HF patients, simultaneous vaccination against influenza and RSV reduced the risk of the primary composite endpoint (hospitalization for HF, all‐cause death, or infection). The main driver of benefit was a lower incidence of infections.
Jan Biegus, Leszek Szenborn, Michał Tkaczyszyn, Robert Zymlinski, Gad Cotter, Michał Zakliczynski, Krzysztof Reczuch, Mateusz Guzik, Szymon Urban, Marta Rosiek‐Biegus, Berenika Jankowiak, Gracjan Iwanek, Marta Wleklik, Marat Fudim, Piotr Ponikowski   +14 more
wiley   +1 more source