Results 61 to 70 of about 261,496 (309)

Cholesterol in mRNA‐Lipid Nanoparticles can be Replaced with the Synthetic Mycobacterial Monomycoloyl Glycerol Analogue MMG‐1

Advanced Functional Materials, EarlyView.
This study demonstrates that cholesterol in messenger RNA‐lipid nanoparticles (mRNA‐LNPs) can be completely replaced with an immunopotentiating lipid, i.e., a synthetic analogue of the C‐type lectin receptor agonist monomycoloyl glycerol (MMG‐1), without compromising physicochemical properties, in vivo transfection efficiency, and immunogenicity of the
Abhijeet G. Lokras, Saahil S. Baghel, Rune F. Jensen, Aneesh Thakur, Henrik Franzyk, Oskar Thofte, Marco Herrera‐Barrera, Madeleine Landry, Melike Ongun, Ahmad Tami, Marlene P. Thanthrige, Eva Callens, Corinne Beinat, Thomas Rades, Søren R. Paludan, Kristian Riesbeck, Ida Rosenkrands, Dennis Christensen, Gabriel K. Pedersen, Camilla Foged   +19 more
wiley   +1 more source

COVID-19 pandemic impacts to Dentistry

RGO: Revista Gaúcha de Odontologia, 2020
Objective: To achieve a literature review on the impacts of COVID-19 on dentistry. Methods: Analysis of scientific articles contained in the LILACS and PubMed platforms that fulfill the informative purpose of the research.
Matheus Simões MEDEIROS, Haniel Laurentino Ferreira dos SANTOS, Jaqueline Oliveira BARRETO, Julliana Cariry Palhano FREIRE, Eduardo DIAS-RIBEIRO   +4 more
doaj   +1 more source

Impact of novel coronavirus infection on urogenital system. Immunonutrition as a method of pathogenetic therapy in patients with COVID-19

Клинический разбор в общей медицине, 2021
On December 12, 2019, the novel coronavirus was identified in Wuhan, China, which caused the outbreak of severe acute respiratory syndrome (COVID-19) in human population, spreading rapidly all over the world; on March 11, 2020 the World Health ...
Ekaterina V. Kulchavenya
doaj   +1 more source

Dental Office Prevention of Coronavirus Infection [PDF]

European Journal of Dentistry, 2020
AbstractCoronavirus disease is now spreading in different countries of the world. The alarmism created through the media also creates confusion in people about virus spreading. The health care environments among which the dental practice could be places of spread of the virus, especially places where patients with systemic pathology could be exposed to
D'Amico C., Bocchieri S., De Stefano R., Gorassini F., Surace G., Amoroso G., Scoglio C., Mastroieni R., Gambino D., Amantia E. M., Marino S., Stumpo C., Fiorillo L.   +12 more
openaire   +3 more sources

Membrane Fusion‐Inspired Nanomaterials: Emerging Strategies for Infectious Disease and Cancer Diagnostics

Advanced Healthcare Materials, EarlyView.
Membrane fusion‐inspired nanomaterials offer transformative potential in diagnostics by mimicking natural fusion processes to achieve highly sensitive and specific detection of disease biomarkers. This review highlights recent advancements in nanomaterial functionalization strategies, signal amplification systems, and stimuli‐responsive fusion designs,
Sojeong Lee, Khulan Nyamzaya, Jueun Han, Yejin Song, Jihee Lee, Jung Hyun Jo, Seungmin Bang, Eun‐Kyung Lim, Seungjoo Haam, Eunjung Kim   +9 more
wiley   +1 more source

Impact of Nanoparticle Stiffness on Endosomal Escape and Signaling Pathways in Cytosolic Delivery

Advanced Healthcare Materials, EarlyView.
Nanoparticle (NP) stiffness affects cellular uptake, but its impact on intracellular distribution remains unclear. This study synthesizes silica nanocapsules with varying stiffness, inspired by viral mechanisms, and applies assays to measure cellular uptake and escape efficiency.
Yali Zhang, Yue Hui, Zichao Guo, Dawei Liu, Yun Liu, Huajian Gao, Chun‐Xia Zhao   +6 more
wiley   +1 more source

Coronavirus Infection and Cholesterol Metabolism

Frontiers in Immunology, 2022
Host cholesterol metabolism remodeling is significantly associated with the spread of human pathogenic coronaviruses, suggesting virus-host relationships could be affected by cholesterol-modifying drugs.
Jun Dai, Jun Dai, Jun Dai, Huan Wang, Ying Liao, Lei Tan, Yingjie Sun, Cuiping Song, Weiwei Liu, Xusheng Qiu, Chan Ding, Chan Ding   +11 more
doaj   +1 more source

The Cell Biology of Coronavirus Infection [PDF]

, 2001
The ability to obtain entire volume data on infected cells will allow us to define much more accurately the interactions of viral proteins with host cell structures such as ER, Golgi, and cytoskeletal elements. In addition, the demonstrated ability to express viral proteins fused to fluorescent markers in in live cells will allow us to follow specific ...
Erik Prentice, Mark R. Denison
openaire   +3 more sources

Novel coronavirus infection and children.

Acta bio-medica : Atenei Parmensis, 2020
Coronavirus disease 2019 (COVID-19) is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Its outbreak in many states of the world, forced the World Health Organization (WHO) to declare a pandemic. Currently, COVID-19 has infected 1 991 562 patients causing 130 885 deaths globally as of 16 April 2020.
Nadia Rossi, Federica Cavallo, Francesco Chiarelli   +2 more
openaire   +3 more sources

Automated Label‐Free Assay for Viral Detection and Inhibitor Screening via Biomembrane‐Functionalized Microelectrode Arrays

Advanced Materials, EarlyView.
A bioelectronic sensor integrating 2D cell membranes with organic microelectrode arrays enables detection of SARS‐CoV‐2 fusion pathways. Natively‐expressed viral receptors promote monitoring of viral entry and screening of antibody‐based inhibitors.
Zixuan Lu, Jeremy Treiber, Konstantinos Kallitsis, Ekaterina Selivanovitch, Alexandra Wheeler, Maria Lopez‐Cavestany, Zhongmou Chao, Sarah L Barron, Ju An Park, Darius Hoven, Anna Scheeder, Aimee Withers, Becky M. Hess, Clemens F. Kaminski, Alberto Salleo, Anna‐Maria Pappa, Susan Daniel, Róisín M Owens   +17 more
wiley   +1 more source