Results 31 to 40 of about 1,162,813 (286)

TOLLIP Inhibits Psoriasis Progression via Suppressing PKM2‐Mediated Glycolysis in Keratinocytes

Advanced Science, EarlyView.
In this study, we identify TOLLIP as a critical regulator of psoriasis pathogenesis through its modulation of glycolytic metabolism. Our findings establish the TOLLIP‐PKM2‐glycolysis axis as a key mechanism linking metabolic reprogramming to psoriasis pathogenesis, and propose TOLLIP as a promising therapeutic target.
Xiuhuan Jiang, Guoying Miao, Na Shen, Qingxia Han, Xiaoru Han, Zichang Qiao, Kexin Feng, Zhuo Tan, Yaguang Wang, Xiuhua Liu, Chen Wu, Zhenzhen Yan   +11 more
wiley   +1 more source

Autoantigen mRNA‐LNP Vaccination Drives Therapeutic Efficacy in Preclinical Models for Autoimmunity

Advanced Science, EarlyView.
Systemic and intramuscular delivery of autoantigen mRNA via lipid nanoparticles reprograms antigen‐presenting cells toward a mature, homeostatic state, driving antigen‐specific T cell exhaustion and providing therapeutic efficacy across autoimmune disease models.
Paulien Baeten, Karen Beets, Tessa Schalley, Janne Verreycken, Gayel Duran, Daphne Lintsen, Lisa Schuetz, Xue Zhong, Rinke Nieuwschepen, Melissa Schepers, Brecht Moonen, Jeroen Bogie, Jana Van Broeckhoven, Carlo Heirman, Jurgen Van den Heuvel, Bart Vanderborght, Ismael Varela, Roxanne Nouille, Lotte Jacobs, Jessica Filtjens, Sabah Kasmi, Elise Seynaeve, Veronica Mavrovouna, Jana De Vrieze, Michael A. Brehm, Sandra Maréchal, Sophie Janssens, Florence Lambolez, Niels Hellings, Stefaan De Koker, Bieke Broux   +30 more
wiley   +1 more source

Impact of Corporate Entrepreneurship and Human Resources Management Practices on Organisational Performance: The Mediating Role of Employee Engagement

International Journal of Applied Research in Business and Management
Corporate entrepreneurship positively impacts organizational growth and profitability by offering a competitive edge over innovation-driven technology advancements and a tumultuous global marketplace.
Charles Vinyu, Norman Chiliya, Hlanganipai Ngirande   +2 more
doaj   +1 more source

AN EMPIRICAL EXPLORATION OF CORPORATE ENTREPRENEURIAL ORIENTATION IN BIHOR COUNTY ROMANIA [PDF]

Annals of the University of Oradea: Economic Science, 2014
According to Schumpeter (1934) an entrepreneur is an individual who innovates and creates new combinations. Today entrepreneurship refers to a process of opportunity recognition and pursuit that leads to growth.
Bucurean Mirela, Florian Gyula Laszlo
doaj  

The mediating role of absorptive capacity in the relationship between transformational leadership and corporate entrepreneurship

Cogent Business & Management, 2023
Absorptive capacity is widely acknowledged as a critical driver of innovation, business development, and self-renewal through the acquisition, transformation, assimilation, and application of knowledge.
Samer Ali Al-Shami, Salama Jamal Rafeea, Massila Kamalrudin, Tika Widiastuti, Abdullah Al Mamun   +4 more
doaj   +1 more source

HD‐tDCS Restores Perivascular AQP4 Polarization via PPARγ Modulation to Enhance Glymphatic Clearance After Intracerebral Hemorrhage in Mice

Advanced Science, EarlyView.
HD‐tDCS promotes recovery after intracerebral hemorrhage by enhancing PPARγ‐dependent astrocyte remodeling in a mouse model of ICH. This process suppresses proinflammatory astrocytic activation, restores perivascular AQP4 repolarization, and improves glymphatic influx and efflux, thereby facilitating hematoma and perihematomal edema clearance and ...
Zhiming Li, Yingmei Zhang, Qianqian Tong, Zhitao Gong, Shanyu Zhang, Zhen Qian, Hui Zhang, Qian Yao, Qi Li   +8 more
wiley   +1 more source

Does the Intuition of Top Managers Influence Corporate Entrepreneurship?

Administrative Sciences
Corporate entrepreneurship is critical in determining a firm’s sustainability. Traditionally, middle managers have been believed to lead corporate entrepreneurship by developing relationships between top managers and subordinates.
Karin Kurata, Itsuki Kageyama, Yoshiyuki Kobayashi, Kota Kodama, Xiang Li, Yeongjoo Lim   +5 more
doaj   +1 more source

YAP1‐Driven Pathogenic Fibro‐Adipogenic Progenitors Secrete IL‐6 and FGF21 to Mediate Muscle‐Bone Crosstalk and Promote Bone Loss

Advanced Science, EarlyView.
Fibro‐adipogenic progenitors (FAPs) in atrophic muscle undergo YAP1‐driven pathogenic activation, secreting IL‐6 and FGF21 as bone‐catabolic myokines that mediate muscle‐bone crosstalk and promote bone loss. Genetic or pharmacological targeting of this YAP1‐FAP‐myokine axis rescues skeletal deterioration, identifying FAP‐derived myokines as therapeutic
Xiaoyu Cai, Tao Xu, Rui Ma, Weikun Meng, Shutao Gao, Yakefu Abulizi, Alafate Kahaer, Chuanhui Xun, Maierdan Maimaiti, Rui Cao, Weidong Liang, Polati Maimaiti, Qiang Deng, Jun Sheng, Ting Wang, Mingchong Liu, Weibin Sheng   +16 more
wiley   +1 more source

Analytic hierarchy process analysis for choosing a corporate social entrepreneurship strategy

Management şi Marketing, 2015
After conducting an extensive analysis of both the specialised literature and practice and identifying three types of corporate social entrepreneurship in my PhD thesis titled “Corporate social entrepreneurship - the new paradigm of reshaping and ...
Hadad Shahrazad
doaj   +1 more source

Corporate governance and corporate entrepreneurship in different organizational forms

, 2017
In today’s society, products and services are offered in a number of different organizational forms: leisure activities are offered by not-for-profit associations or privately held firms, waste disposal services by local government corporations or ...
Collin, Sven-Olof,, Kristianstad University., Smith, Elin,   +2 more
core   +1 more source