Results 131 to 140 of about 437,448 (305)
Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum
FEBS Open Bio, EarlyView.Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik +6 more
wiley +1 more source
Does It Pay, at the Margin, to Work and Save? -- Measuring Effective Marginal Taxes on Americans' Labor Supply and Saving [PDF]
Building on Gokhale, Kotlikoff, and Sluchynsky's (2002) study of Americans' incentives to work full or part time, this paper uses ESPlanner, a life-cycle financial planning program, in conjunction with detailed modeling of transfer programs to determine ...
David Rapson, Laurence J. Kotlikoff
core
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
Product Service Systems and Sustainability: Opportunities for Sustainable Solutions [PDF]
, 2002 Given that the concept of PSS is beginning to 'catch on' and gain attention, it is time for UNEP to contribute to, and influence the progress of PSS, to ensure that in concept and application it incorporates the idea of sustainability.
Carlo Vezzoli, Ezio Manzini
core
FEBS Open Bio, EarlyView.This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia +3 more
wiley +1 more source
Relationship between Investment Opportunities and Earnings in according to Companies Life Cycle [PDF]
مطالعات تجربی حسابداری مالی, 2012 Intrinsic value of a company depends on its financial and investment decisions. Companies with different investment opportunities are priced different in the market.
Mona Abednazari +2 more
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Operational efficiency subpanel advanced mission control [PDF]
Herein, the term mission control will be taken quite broadly to include both ground and space based operations as well as the information infrastructure necessary to support such operations.
Friedland, Peter
core +1 more source
An asset management strategy to accommodate a changing climate [PDF]
, 2006 Climate change is a significant factor that will affect how people live and work in future. In light of this and of international initiatives on limitations of emissions, the changing climatic conditions will affect the existing building fabric, and ...
Desai, Apeksha, Jones, Keith
core
Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs
FEBS Open Bio, EarlyView.Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner +7 more
wiley +1 more source
LIFE CYCLE OF INFORMATION SYSTEMS
Системный анализ и прикладная информатика, 2015 This work is a generalization of the theoretical propositions related to the life cycle of information systems. There was given the definition of the life cycle, specify which items you should include every step of the cycle.
Y. S. Sennik, R. I. Grebennikov
doaj