Results 131 to 140 of about 9,165,708 (258)

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

open access: yesMolecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Stock ownership and corporate performance in Japan: Corporate governance by institutional investors [PDF]

open access: yes
Faced with an aging population and a low fertility rate, Japan finds it increasingly essential to shift diminishing national savings into productive investment in order to preserve the dynamism of its economy.
SHINADA Naoki
core  

Spatial biology in cancer epigenetics

open access: yesMolecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Effect of board and ownership attributes on corporate performance in transition economy

open access: yesCogent Business & Management
Corporate governance is one of the key factors in corporate performance for the economy. In particular, for a transition economy, which is on the way of developing economies from the least developing economy, the relevant attributes of corporate ...
Mofijul Hoq Masum   +2 more
doaj   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

open access: yesMolecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche   +10 more
wiley   +1 more source

Control Mechanism and Value of Firm: Empirical Evidence from Indonesia Capital Market

open access: yesInternational Research Journal of Business Studies, 2013
This research discusses about the roles of institutional ownership and leverage as control mechanism over agency conflict and how it affects corporate performance. Agency conflict is a result of expropriation via tunneling on asset utilization.
Christian Herdinata   +2 more
doaj  

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