Results 151 to 160 of about 1,241,211 (310)

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

CAN FINANCIAL FLEXIBILITY ENHANCE A COMPANY'S VALUATION DURING CHALLENGING PERIODS? : AN ANALYSIS DURING THE VUCA SITUATION

Фінансово-кредитна діяльність: проблеми теорії та практики
This study investigates how financial flexibility can enhance corporate value, especially in a VUCA (volatility, uncertainty, complexity, and ambiguity) environment such as the COVID-19 pandemic.
Krismi Budi Sienatra, Sumiati Sumiati, Risna Wijayanti, Andarwati Andarwati   +3 more
doaj   +1 more source

Relationship Between Eco Transformational Leadership, Eco Training, and Employee Eco Behavior on Sustainable Corporate Performance of SMEs. [PDF]

Front Psychol, 2022
Novita D, Hidayatulloh AN, Renwarin JMJ, Santoso R, Mardikaningsih R.   +4 more
europepmc   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

A study on the relationship between compensation gap within the top management team and corporate performance: An empirical research based on the moderation effect of fairness preference. [PDF]

Front Psychol, 2022
Wang X, Chen X, Zhou H, You X.
europepmc   +1 more source

Corporate ESG Performance and Corporate Value

Transactions on Social Science, Education and Humanities Research
In the context of China's green development transformation and high-quality development, it is of great significance to actively promote enterprises to practice the concept of ESG development. In order to study the impact of ESG on enterprise value, this paper empirically examines the impact of ESG performance on enterprise value and its mechanism of ...
openaire   +1 more source

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

Is cash the panacea of the COVID-19 pandemic: Evidence from corporate performance. [PDF]

Financ Res Lett, 2022
Zheng M.
europepmc   +1 more source

PENGARUH GOOD CORPORATE GOVERNANCE DAN LEVERAGE TERHADAP NILAI PERUSAHAAN DENGAN KINERJA KEUANGAN SEBAGAI VARIABEL MEDIASI PADA PERUSAHAAN SUB SEKTOR MAKANAN DAN MINUMAN DI BURSA EFEK INDONESIA [PDF]

This study was conducted with the aim of evaluating the effect of Good Corporate Governance on firm value, with financial performance as a mediating variable.
Ramadhan, Tegar Gilang
core  

Benchmarking Philanthropy [PDF]

, 2004
The CEO's question of "How are we doing?" can strike fear into the hearts of executives responsible for corporate philanthropy. Unlike almost every other area of corporate activity, there are no tried and true methods for benchmarking philanthropic ...
John Kania
core