Results 201 to 210 of about 1,693,579 (273)

Assessing corporate transition plans using a production asset-based planning approach. [PDF]

Nat Commun
Kampmann D, Rekker S, Ruan M, Shrimali G.   +3 more
europepmc   +1 more source

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source

Polygenic risk scores for premagnetic resonance imaging risk stratification in men with clinically suspected prostate cancer. [PDF]

J Natl Cancer Inst
Fischer MP, Mayer A, Braun A, Kraft J, Hansen CM, Baumgärtner GL, Asbach P, Padhani AR, Penzkofer T, König F, Awasthi S, Makowski MR, Ripke S, Hamm CA.   +13 more
europepmc   +1 more source

Type I interferons modulate autophagy to shape gemcitabine response in pancreatic cancer cells

FEBS Open Bio, EarlyView.
Type I interferons differentially modulate autophagy and the response of pancreatic cancer cells to gemcitabine. IFNα2b stimulates autophagic flux and protects cells from gemcitabine‐induced cell death, contributing to chemoresistance. In contrast, IFNβ1a inhibits autophagosome formation and enhances gemcitabine‐induced cell death, resulting in ...
Lucy E. Bonilla, Martín M. Ledesma, Santiago A. Behr, Matías A. Pibuel, María L. Palanek, Daniel H. Grasso, Maria N. Garcia, Juan Garona, Silvina L. Lompardía, Elida Álvarez, Daniela L. Papademetrio   +10 more
wiley   +1 more source

Planning to fail? Credibility and financing of corporate transition plans in hard-to-abate sectors. [PDF]

iScience
Klein SMA, Polzin F, Urbach X.
europepmc   +1 more source

Engaging stakeholders, shaping AI ethics: Targeted engagement in corporate AI ethics statements. [PDF]

PLoS One
Ye M, Friginal E.
europepmc   +1 more source

Five‐Year Outcomes of Laparoscopic Sphincter‐Preserving Surgery for Rectal Cancer: A Prospective Study in Elderly Vietnamese Patients

Aging and Cancer, EarlyView.
This prospective study demonstrates that laparoscopic sphincter‐preserving surgery is feasible for elderly patients. While overall survival reaches 70% at 5 years, advanced T‐stage and the omission of neoadjuvant therapy significantly drive recurrence, highlighting the need for personalized geriatric protocols despite logistical challenges.
Huu Duc Ho, Quang Le, Ngoc Thach Tran, Van Viet Ung, Loc Vu   +4 more
wiley   +1 more source

The politicization of ESG investing shows why ESG metrics cannot be depoliticized. [PDF]

Humanit Soc Sci Commun
Chen S.
europepmc   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Research on a financial fraud identification model by fusing a convolutional neural network. [PDF]

PLoS One
Lu H, Zhu S, Zhang Y, Lv R.
europepmc   +1 more source