Results 101 to 110 of about 2,020,884 (249)

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

COVID-19 impact and resilience mechanisms in Limpopo province’s farming communities

Discover Food
The differential impacts of COVID-19 on small, medium, and large-scale farmers in South Africa are still not fully understood, creating challenges for resilience to future pandemics.
Lazarus Chapungu, Godwell Nhamo, Munyaradzi Chitakira, Khangwelo Desmond Musetsho   +3 more
doaj   +1 more source

Toward a Sustainable Paradigm: Redefining Corporate Purpose in the EU Context

Systems
Recent societal transformations have intensified debates on corporate purpose, yet empirical evidence linking these debates to measurable sustainability outcomes remains fragmented.
Claudiu George Bocean, Anca Antoaneta Vărzaru   +1 more
doaj   +1 more source

Corporate Sustainability Development Strategy and Corporate Environmental Governance-The Moderating Role of Corporate Environmental Investments. [PDF]

Int J Environ Res Public Health, 2023
Ao X, Ong TS, Teh BH.
europepmc   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Environmental Sustainability in Practice

, 2017
1. Introduction: What is Environmental Sustainability?2. Sustainability Education3. Environmental Planning and Management4. Sustainable Agriculture5. Geospatial Technologies and Environmental Sustainability6.
Environmental Sustainability Research Centre
core   +1 more source

Corporate sustainability

, 2012
Mestrado em Gestão ...
openaire   +3 more sources

Brace for Impact: Facing the AI Revolution and Geopolitical Shifts in a Future Societal Scenario for 2025–2040

Societies
This study investigates the profound and multifaceted impacts of Artificial Intelligence (AI) and geopolitical developments on global dynamics by 2040.
Michael Gerlich
doaj   +1 more source

A systematic literature review on corporate sustainability: contributions, barriers, innovations and future possibilities. [PDF]

Environ Dev Sustain, 2023
de Oliveira UR, Menezes RP, Fernandes VA.   +2 more
europepmc   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source