Results 81 to 90 of about 19,462 (249)

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

AI Tools in Society: Impacts on Cognitive Offloading and the Future of Critical Thinking

Societies
The proliferation of artificial intelligence (AI) tools has transformed numerous aspects of daily life, yet its impact on critical thinking remains underexplored. This study investigates the relationship between AI tool usage and critical thinking skills,
Michael Gerlich
doaj   +1 more source

Corporate Sustainability Development Strategy and Corporate Environmental Governance-The Moderating Role of Corporate Environmental Investments. [PDF]

Int J Environ Res Public Health, 2023
Ao X, Ong TS, Teh BH.
europepmc   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Toward a Sustainable Paradigm: Redefining Corporate Purpose in the EU Context

Systems
Recent societal transformations have intensified debates on corporate purpose, yet empirical evidence linking these debates to measurable sustainability outcomes remains fragmented.
Claudiu George Bocean, Anca Antoaneta Vărzaru   +1 more
doaj   +1 more source

A systematic literature review on corporate sustainability: contributions, barriers, innovations and future possibilities. [PDF]

Environ Dev Sustain, 2023
de Oliveira UR, Menezes RP, Fernandes VA.   +2 more
europepmc   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Cultural inclusion and corporate sustainability: evidence from food culture and corporate total factor productivity in China. [PDF]

Humanit Soc Sci Commun, 2023
Sun G, Lin X, Chen J, Xu N, Xiong P, Li H.   +5 more
europepmc   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Brace for Impact: Facing the AI Revolution and Geopolitical Shifts in a Future Societal Scenario for 2025–2040

Societies
This study investigates the profound and multifaceted impacts of Artificial Intelligence (AI) and geopolitical developments on global dynamics by 2040.
Michael Gerlich
doaj   +1 more source