Results 81 to 90 of about 2,922,340 (285)

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

The Transition to an Impact-Based Approach in Sustainability and Financial Reporting

Ekonomi, Politika & Finans Araştırmaları Dergisi
This paper analyzes the paradigm shift in sustainability and financial accounting on a sample of the first 100 companies reporting under the European Union’s Corporate Sustainability Reporting Directive (CSRD). Drawing on the shift from financial-focused
Ayşenur Tarakcıoğlu Altınay, Barış Sardoğan   +1 more
doaj   +1 more source

Overview of XBRL Taxonomy Usage for Structured Sustainability Reporting in European Filings

Chemical Engineering Transactions, 2023
The increasing requirement for businesses to disclose sustainability information digitally has prompted significant changes in the content and format of Environmental, Social, and Governance (ESG) disclosures.
Alex Suta, Orsolya Pintes, Péter Molnár, Bence Lukács, Loránd Kedves, Árpád Tóth   +5 more
doaj  

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

The Sustainability Reporting Ripple: Direct and Indirect Implications of the EU Corporate Sustainability Reporting Directive for SME Actors

, 2023
Macerata ...
openaire   +1 more source

Considerations Regarding the Sustainability Reporting Under the European Sustainability Reporting Standard in the Context of the Corporate Sustainability Reporting Directive

International Journal of Advanced Engineering and Management Research
Climate change is one of the greatest threats facing the entire world. It affects not just individuals, but each of us directly and personally. The threat of global destruction driven by climate change must be reduced with the help of the European Green Deal.
PITZ Fabian, PLESEA Doru Alexandru, HEINEMANN Bastian Leonard, SOEHNER Selina   +3 more
openaire   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Motivations for Corporate Social Reporting and Non-Reporting in Malaysia: An Exploratory Study From a Public Relations Perspective [PDF]

, 2009
Corporate social reporting, embracing the triple bottom line reporting concept, entails the reporting of economic, social and environmental performance as opposed to the more narrow focus on conventional financial reporting.
Tee, Keng Kok
core  

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source