Results 141 to 150 of about 1,137,160 (327)

Allosteric Modulation of Pathological Ataxin‐3 Aggregation: A Path to Spinocerebellar Ataxia Type‐3 Therapies

open access: yesAdvanced Science, EarlyView.
This study uncovers a new allosteric site in the Josephin domain of ataxin‐3 targeted by the molecular tweezer CLR01, which modulates protein aggregation, improves synaptic function in neuronal cells, and delays motor dysfunction in animal models.
Alexandra Silva   +28 more
wiley   +1 more source

Motivating a volunteer workforce in the criminal justice system [PDF]

open access: yes, 2014
The Optional Protocol to the Convention against Torture and Other Cruel, Inhuman or Degrading Treatment or Punishment (OPCAT) requires that police detention processes are monitored and inspected.
Biggs, David M, Eccles, Thomas B
core  

Vm–MSI: a Vancomycin–Antimicrobial Peptide Conjugate Combating Resistant Bacteria and Broadening the Antimicrobial Spectrum

open access: yesAdvanced Science, EarlyView.
A series of vancomycin‐antimicrobial peptide conjugates is synthesized and evaluated to identify the optimal combination. Vm‐MSI, selected from multiple candidates, exhibited potent activity against vancomycin‐resistant and Gram‐negative bacteria by disrupting membranes and inducing oxidative stress, thereby expanding vancomycin's antibacterial ...
Shuangyu Li   +7 more
wiley   +1 more source

Using Volunteers in Naturalization Workshops [PDF]

open access: yes, 2014
Volunteers are a critical component of efficient naturalization service delivery, especially in group processing workshops, which the New Americans Campaign (NAC) promotes. This toolkit provides recommendations for organizations on how to recruit, train,

core  

Sleep Alters the Velocity of Physiological Brain Pulsations in Humans

open access: yesAdvanced Science, EarlyView.
Sleep alters I/CSF oscillatory flow, driven by increased respiratory (29%) and vasomotor pulsation (21%) velocities, while cardiovascular pulsations decreased by (22%). Velocity is quantified using optical flow analysis of MREG data. Spectral power increases alongside these pulsations (spatial correlation, r = 0.35 and r = 0.39, respectively ...
Ahmed Elabasy   +13 more
wiley   +1 more source

The new capitalist philanthropy and the intensification of the teacher’s work: reflections on corporate volunteering

open access: yesEducação: Teoria e Prática, 2012
This paper summarizes research results obtained by the authors on the new formats of capitalist philanthropy through volunteering work. It highlights, especially,teaching practices developed in companies with “social responsibility”, consolidating a new ...
Maria Vieira Silva   +2 more
doaj  

Weathering the Storm: The State of Corporate Citizenship in the United States 2009 [PDF]

open access: yes, 2009
Presents results of a biennial survey of senior executives on support for various forms of corporate citizenship, challenges of integrating corporate citizenship into core business practices, effects of the recession, and partnerships to address ...

core  

DRD2 Deficiency Underlies Pituitary Adenoma Dependent on Escherichia coli Translocation from the Gut

open access: yesAdvanced Science, EarlyView.
Dopamine receptor D2 (DRD2) deficiency disrupts epithelial barrier integrity in both the gut and pituitary gland, facilitating translocation of gut‐derived Escherichia coli into pituitary tissue. Intratumoral E. coli are phagocytosed by microglia, triggering GSDMD‐dependent pyroptosis and HMGB1 release, which subsequently activates MAPK signaling to ...
Xian‐jun Su   +16 more
wiley   +1 more source

ESTRATÉGIAS DE RESPONSABILIDADE SOCIAL CORPORATIVA: UM ESTUDO SOBRE OS 231 CASOS CONCRETOS DO INSTITUTO ETHOS

open access: yesRevista Eletrônica de Ciência Administrativa, 2006
<strong>Resumo</strong><br />Um perfil das estratégias de Responsabilidade Social Corporativa adotadas por empresas no Brasil é o objetivo<br />principal deste trabalho.
Franciara Maria de Oliveira
doaj  

Volunteering [PDF]

open access: yes, 2010
In recent decades, there has been a burgeoning interest in the study of volunteering, and the number of publications devoted to volunteering has grown exponentially.
Cnaan, Ram A   +2 more
core  

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