Results 261 to 270 of about 60,898 (347)

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Editorial: The challenges of consciousness research in light of the variations of conscious experience. [PDF]

Front Psychol
Gutland C, Katyal S, Li K, Muñoz MV, Wendt AN.   +4 more
europepmc   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

Dreaming as representation : Wild grass and realism\u27s responsibility = 夢的表意 :《野草》與現實主義的責任

, 2014
CHAN, Roy
core  

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

The family myth in nursing care for children in psychological distress. [PDF]

Rev Esc Enferm USP
Delfini G, Toledo VP, Garcia APRF.
europepmc   +1 more source

Development of a physical literacy consensus statement for Chile: study protocol. [PDF]

Front Public Health
Carcamo-Oyarzun J, Rivera-Gutierrez C, Henriquez-Alvear L, Delgado-Floody P, Ferbol C, Diaz-Alvarado M, Cumilef-Bustamante P, Martinez-Lopez N, Guarda-Saavedra P, Candia-Cabrera P, Pavez-Adasme G, Castillo-Retamal M, Vargas-Vitoria R, Ibarra-Mora J, Veas-Alfaro L, Diaz-Guaita R, Añazco-Martinez L, Estevan I.   +17 more
europepmc   +1 more source

<i><b>"I'm glad you're fat, just like me, Emma. Otherwise, I would never have met you."</b></i> <b>Children and adolescents' lived experiences of participating in a lifestyle intervention in Norway- a qualitative study.</b> [PDF]

Int J Qual Stud Health Well-being
Wik ACM, Bjorbækmo WS, Groven KS.
europepmc   +1 more source