Results 31 to 40 of about 249,622 (267)

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Regional indices of biotic integrity outperform salinity-based and coastwide indices for tidal streams

Ecological Indicators
Human activities have degraded tidal streams by changing the surrounding land, altering freshwater inflows, and reducing water quality. This degradation has affected the faunal communities inhabiting tidal streams.
Stacy N. Trackenberg, Terence A. Palmer, Natasha J. Breaux, Alexis J. Neffinger, Jennifer Beseres Pollack   +4 more
doaj   +1 more source

A Deep Learning Based Method to Delineate the Wet/Dry Shoreline and Compute Its Elevation Using High-Resolution UAS Imagery

Remote Sensing, 2022
Automatically detecting the wet/dry shoreline from remote sensing imagery has many benefits for beach management in coastal areas by enabling managers to take measures to protect wildlife during high water events.
Marina Vicens-Miquel, F. Antonio Medrano, Philippe E. Tissot, Hamid Kamangir, Michael J. Starek, Katie Colburn   +5 more
doaj   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

Developmental and Epileptic Encephalopathy due to Biallelic Pathogenic Variants in PIGM

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective PIGM encodes a critical enzyme in the glycosylphosphatidylinositol (GPI)‐anchor biosynthesis pathway. While promoter‐region mutations in PIGM have been associated with a relatively mild phenotype characterized by portal vein thrombosis and absence seizures, recent evidence suggests that coding‐region mutations result in a more severe
Júlia Sala‐Coromina, Anna Marcé‐Grau, Barbara Masotto, Marta Codina, Lamia BenJemaa, Yasmina Elaribi, Mónica Martinez‐Gallo, Roger Colobran, Angel Sanchez‐Montañez, Irene Valenzuela, Yoshiko Murakami, Alfons Macaya   +11 more
wiley   +1 more source

Recalcitrant Fungal Prosthetic Joint Infection of the Knee Cleared Using Voriconazole via Intra‐Articular Catheters

Clinical Case Reports
Prosthetic joint infection (PJI) is a high‐cost and high‐morbidity complication of total joint arthroplasty accounting for about 1%–2% of all joint replacements.
Matthew Hnatow, Blake C. Martin, Emma Herrera   +2 more
doaj   +1 more source

Organic matter composition and inorganic nitrogen response to Hurricane Harvey’s negative storm surge in Corpus Christi Bay, Texas

Frontiers in Marine Science, 2022
Extreme weather events, such as tropical storms and hurricanes, are known to deliver large amounts of freshwater (surface runoff) and associated inorganic and organic nutrients to estuaries and the coastal ocean, affecting water quality and nutrient ...
Audrey R. Douglas, Audrey R. Douglas, Dorina Murgulet, Megan Greige, Kousik Das, J. David Felix, Hussain A. Abdulla   +6 more
doaj   +1 more source

Normal‐Appearing White Matter Injury Mediates Chronic Deep Venous Hypoxia and Disease Progression in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore how cerebral hypoxia and Normal‐Appearing White Matter (NAWM) integrity affect MS lesion burden and clinical course. Methods Seventy‐nine MS patients, including 13 clinically isolated syndrome (CIS) patients and 66 relapsing–remitting multiple sclerosis (RRMS) patients, and 44 healthy controls (HCs) were recruited from ...
Xinli Wang, Huiying Wang, Zhizheng Zhuo, Ai Guo, Ke Lv, Decai Tian, Chao Chai, Yunyun Duan, Shuang Xia   +8 more
wiley   +1 more source

Partial Scene Reconstruction for Close Range Photogrammetry Using Deep Learning Pipeline for Region Masking

Remote Sensing, 2022
3D reconstruction is a beneficial technique to generate 3D geometry of scenes or objects for various applications such as computer graphics, industrial construction, and civil engineering.
Mahmoud Eldefrawy, Scott A. King, Michael Starek   +2 more
doaj   +1 more source

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling, Mark D. Parker, Sven Kerst, Richard A. Pasternack, Jacob Tondreau, Marjolein Breur, Gemma M. van Rooijen‐van Leeuwen, Davide Tonduti, Ettore Salsano, Alejandra Darling, Joanna A. E. van Wijk, Susanna Törnroth‐Horsefield, Marianna Bugiani, Petra J. W. Pouwels, Quinten Waisfisz, Marjo S. van der Knaap, Rogier Min   +16 more
wiley   +1 more source