Results 51 to 60 of about 1,291,560 (300)

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Lower-Dimensional Model of the Flow and Transport Processes in Thin Domains by Numerical Averaging Technique

Fluids, 2023
In this work, we present a lower-dimensional model for flow and transport problems in thin domains with rough walls. The full-order model is given for a fully resolved geometry, wherein we consider Stokes flow and a time-dependent diffusion–convection ...
Maria Vasilyeva, Nana Adjoah Mbroh, Mehrube Mehrubeoglu   +2 more
doaj   +1 more source

La variation comme principe d’exploration de corpus :Intérêts et limites de l’analyse lexicométrique interdisciplinaire pour l’étude de discours [PDF]

, 2009
Cette contribution dresse le bilan critique d’une étude de corpus, menée par deux chercheuses de disciplines différentes. Elle vise à définir les conditions d’une pratique scientifique interdisciplinaire de l’analyse des données textuelles à l’intérieur ...
Garric, Nathalie, Capdevielle-Mougnibas, Valérie   +1 more
core   +1 more source

Dactolisib outperforms Rapamycin in potentiating apoptosis induced by XPO1, Bcl‐2 and Mcl‐1 blockade in preclinical glioblastoma models

FEBS Open Bio, EarlyView.
The PAM pathway and its impact on cellular metabolism. Color‐coded key symbols represent Rapamycin (R, orange, targeting mTOR) and Dactolisib (D, green, targeting PI3K/mTOR), indicating their sites of action. Created with BioRenders.com. Glioblastoma resists therapy through interconnected survival programs.
Kai Zhao, Leonie Meyer, Madita Braun, Katharina Otte, Celine Bitter, Maite Pawlik, Hartmann Raifer, Frederik Helmprobst, Axel Pagenstecher, Hans Urban, Michael C. Burger, Michael W. Ronellenfitsch, Joachim P. Steinbach, Jarmila Jedelská, Shamim Bagheri, Behrooz H. Yousefi, Pietro Di Fazio, Markus Luster, Andreas H. Mahnken, Andreas Neubauer, Andreas Burchert, Christopher Nimsky, Jörg W. Bartsch, Tillmann Rusch   +23 more
wiley   +1 more source

Understanding Further the Phenotypic Spectrum of Central Nervous System Inflammatory Demyelinating Disorders Using Unsupervised Clustering

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Central nervous system (CNS) inflammatory demyelinating syndromes, including multiple sclerosis (MS), aquaporin‐4 antibody–positive neuromyelitis optica spectrum disorder (AQP4 + NMOSD), and myelin oligodendrocyte glycoprotein (MOG) antibody–associated disease (MOGAD), occasionally overlap.
Bade Gulec, Elif Everest, Melih Tutuncu, Ugur Bilge, Sabahattin Saip, Ugur Uygunoglu, Aksel Siva   +6 more
wiley   +1 more source

Organic matter composition and inorganic nitrogen response to Hurricane Harvey’s negative storm surge in Corpus Christi Bay, Texas

Frontiers in Marine Science, 2022
Extreme weather events, such as tropical storms and hurricanes, are known to deliver large amounts of freshwater (surface runoff) and associated inorganic and organic nutrients to estuaries and the coastal ocean, affecting water quality and nutrient ...
Audrey R. Douglas, Audrey R. Douglas, Dorina Murgulet, Megan Greige, Kousik Das, J. David Felix, Hussain A. Abdulla   +6 more
doaj   +1 more source

Corpus et stylistique [PDF]

, 2007
Une question lancée comme un défi a sous-tendu ce numéro de Corpus. Parallèlement aux linguistiques de corpus qui commencent à être clairement établies, serait-il envisageable de définir une stylistique de corpus ?
Magri-Mourgues, Véronique
core   +1 more source

Screening Routine Clinical Notes for Epilepsy Surgery Candidates Using Large Language Models

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Epilepsy surgery is severely underutilized despite proven efficacy, with substantial under‐referral of eligible patients in routine clinical practice. This study evaluated the potential role of large language models (LLMs) as decision‐support tools for screening unstructured clinical notes to identify epilepsy surgery candidates and ...
Uriel Fennig, Nadav Amir, Maya Schiller, Roni Loebenstein, Johnatan Nissan, Marina Boxer, Shany Guly Gofrit, Gal Goshen, Sándor Beniczky, Nicola Maggio   +9 more
wiley   +1 more source

Empowering criminal justice majors: developing communication skills for a post-COVID era

Humanities & Social Sciences Communications
This study explores integrating virtual reality (VR) simulations and applied improvisational theater techniques into criminal justice education to address evolving communication challenges, particularly in the wake of the COVID-19 pandemic. Grounded in a
Callie Shaw, Meredith Melville, Joseph Doan, Wendi Pollock, James Ikonomopoulos   +4 more
doaj   +1 more source