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Individualized corrected QT interval is superior to QT interval corrected using the Bazett formula in predicting mutation carriage in families with long QT syndrome

Heart Rhythm, 2017
Long QT syndrome (LQTS) is characterized by reduced penetrance and variable QT prolongation over time, resulting in an estimate of 25% carriers of a pathogenic mutation with a normal corrected QT (QTc) interval on the resting electrocardiogram (ECG).The purpose of this study was to test the hypothesis that an individualized corrected QT interval ...
Robyns, Tomas, Willems, Rik, Vandenberk, Bert, Ector, Joris, Garweg, Christophe, Kuiperi, Cuno, Breckpot, Jeroen, Corveleyn, Anniek, Janssens, Stefan, Heidbuchel, Hein, Nuyens, Dieter   +10 more
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The impact of fever on corrected QT interval

Journal of Electrocardiology, 2017
We were interested in the impact of fever on the QT interval as information on this subject is limited.We performed a retrospective, single centre study over a two year period, ending December 31st, 2013. Participants were identified using an electronic chart review of emergency department records linked to an ECG data base.
Doran, Drew, Adrian, Baranchuk, Wilma, Hopman, Robert J, Brison   +3 more
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QT Interval Correction in Patients with Cirrhosis

Journal of Cardiovascular Electrophysiology, 2006
Introduction: QT interval prolongation is a common electrophysiological abnormality in patients with cirrhosis. As QT interval varies with the heart rate, many QT correction formulas have been proposed, the Bazett's one being the most criticized because it overcorrects the QT interval and may be misleading. This study focused on the QT‐RR relationship
ZAMBRUNI, ANDREA, Di Micoli A., LUBISCO, ALESSANDRO, Domenicali M., TREVISANI, FRANCO, BERNARDI, MAURO   +5 more
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Fast and spurious: Correcting the QT interval

Heart Rhythm, 2016
In an era of immense technological advance, the resting ECG remains at the cornerstone of investigations for the evaluation and treatment of cardiovascular patients. In particular, the QT-interval duration has long been a metric of risk in focused areas such as mendelian long QT syndrome and in broader fields such as antiarrhythmic drug efficacy and ...
Zachary W M, Laksman, Andrew D, Krahn
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Influence of Spinal Anesthesia on Corrected QT Interval

Regional Anesthesia and Pain Medicine, 2005
Prolongation of the QT interval may result in grave cardiac arrhythmias, polymorphic ventricular tachycardia ("torsades de pointes"), and ventricular fibrillation. We assessed the influence of spinal anesthesia on the QTc interval and the potential arrhythmogenicity of this method of anesthesia.Assessment was performed in 20 male unpremedicated ...
Radoslaw, Owczuk, Wioletta, Sawicka, Magdalena A, Wujtewicz, Aleksandra, Kawecka, Jerzy, Lasek, Maria, Wujtewicz   +5 more
openaire   +2 more sources

Corrected QT Interval Changes With Atypical Antipsychotics

Journal of the American Academy of Child & Adolescent Psychiatry, 2015
n this issue of the Journal, the meta-regression analyses by Jensen et al. aim to quantify the effects of antipsychotic I drugs on cardiac QT prolongation in the setting of pediatric randomized or open clinical trials. The common prescription of atypical antipsychotic medication, the known metabolic burden of these agents, and the theoretical potential
Kaizad, Munshi, Mark E, Alexander, Paul, Hammerness   +2 more
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Rate-corrected QT interval: Techniques and limitations

The American Journal of Cardiology, 1993
The duration of the QT interval on the surface electrocardiogram represents the time required for all ventricular depolarization and repolarization processes to occur. Among the many physiologic and pathologic factors that contribute to the QT interval, heart rate plays a major role.
C, Funck-Brentano, P, Jaillon
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Ziprasidone and the Corrected QT Interval

CNS Drugs, 2012
Prolongation of the corrected QT interval (QTc) is understood to be a predictor of risk for ventricular arrhythmia; consequently, data on QTc effects of drugs are used by regulatory bodies to evaluate potential safety risks. Clinical pharmacology studies in adults receiving oral ziprasidone demonstrated a dose-dependent mean increase (4.5-19.5 ...
A John, Camm, Onur N, Karayal, Herbert, Meltzer, Sheela, Kolluri, Cedric, O'Gorman, Jeffrey, Miceli, Thomas, Tensfeldt, John M, Kane   +7 more
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Corrected QT Interval (QT)

1989
The QT interval of the electrocardiogram (ECG) is measured from the onset of ventricular activity to the end of the T wave. Because the QT interval varies with heart rate in normal individuals a “corrected” QT interval is sometimes calculated to factor out heart rate-dependent effects to provide a measure that is independent of rate effects.
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Psychotropic Drugs Associated With Corrected QT Interval Prolongation

Journal of Clinical Psychopharmacology, 2009
To study whether listed putative corrected QT (QTc)-prolonging psychotropic drugs indeed prolong the QTc interval under everyday circumstances and to evaluate whether this is a class effect or an individual drug effect, we conducted a prospective population-based cohort study.This study was conducted as part of the Rotterdam Study and included 3377 men
van Noord, C, Straus, SM, Sturkenboom, MC, Hofman, A, Aarnoudse, AJ, BAGNARDI, VINCENZO, Kors, JA, Newton Cheh, C, Witteman, JC, Stricker BH   +9 more
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