Results 241 to 250 of about 1,303,482 (284)

Fast and spurious: Correcting the QT interval

Heart Rhythm, 2016
In an era of immense technological advance, the resting ECG remains at the cornerstone of investigations for the evaluation and treatment of cardiovascular patients. In particular, the QT-interval duration has long been a metric of risk in focused areas such as mendelian long QT syndrome and in broader fields such as antiarrhythmic drug efficacy and ...
Zachary W M, Laksman, Andrew D, Krahn
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Influence of Spinal Anesthesia on Corrected QT Interval

Regional Anesthesia and Pain Medicine, 2005
Prolongation of the QT interval may result in grave cardiac arrhythmias, polymorphic ventricular tachycardia ("torsades de pointes"), and ventricular fibrillation. We assessed the influence of spinal anesthesia on the QTc interval and the potential arrhythmogenicity of this method of anesthesia.Assessment was performed in 20 male unpremedicated ...
Radosław Owczuk, Wioletta Sawicka, Magdalena A. Wujtewicz, Aleksandra Kawecka, Jerzy Lasek, Maria Wujtewicz   +5 more
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Corrected QT Interval Changes With Atypical Antipsychotics

Journal of the American Academy of Child & Adolescent Psychiatry, 2015
n this issue of the Journal, the meta-regression analyses by Jensen et al. aim to quantify the effects of antipsychotic I drugs on cardiac QT prolongation in the setting of pediatric randomized or open clinical trials. The common prescription of atypical antipsychotic medication, the known metabolic burden of these agents, and the theoretical potential
Kaizad, Munshi, Mark E, Alexander, Paul, Hammerness   +2 more
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Corrected QT Interval (QT)

1989
The QT interval of the electrocardiogram (ECG) is measured from the onset of ventricular activity to the end of the T wave. Because the QT interval varies with heart rate in normal individuals a “corrected” QT interval is sometimes calculated to factor out heart rate-dependent effects to provide a measure that is independent of rate effects.
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Rate-corrected QT interval: Techniques and limitations

The American Journal of Cardiology, 1993
The duration of the QT interval on the surface electrocardiogram represents the time required for all ventricular depolarization and repolarization processes to occur. Among the many physiologic and pathologic factors that contribute to the QT interval, heart rate plays a major role.
C, Funck-Brentano, P, Jaillon
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Ziprasidone and the Corrected QT Interval

CNS Drugs, 2012
Prolongation of the corrected QT interval (QTc) is understood to be a predictor of risk for ventricular arrhythmia; consequently, data on QTc effects of drugs are used by regulatory bodies to evaluate potential safety risks. Clinical pharmacology studies in adults receiving oral ziprasidone demonstrated a dose-dependent mean increase (4.5-19.5 ...
A John, Camm, Onur N, Karayal, Herbert, Meltzer, Sheela, Kolluri, Cedric, O'Gorman, Jeffrey, Miceli, Thomas, Tensfeldt, John M, Kane   +7 more
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The Effect of Cisapride on the Corrected QT Interval and QT Dispersion in Premature Infants

Journal of Pediatric Gastroenterology and Nutrition, 2001
ABSTRACTBackgroundCisapride is used frequently in premature neonates as a gastrointestinal prokinetic drug. Concerns exist, however, about its safety because of its effect on the QT interval. Premature infants could be at higher risk for side effects because of their immaturity.
F, Cools, A, Benatar, A, Bougatef, Y, Vandenplas   +3 more
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Psychotropic Drugs Associated With Corrected QT Interval Prolongation

Journal of Clinical Psychopharmacology, 2009
To study whether listed putative corrected QT (QTc)-prolonging psychotropic drugs indeed prolong the QTc interval under everyday circumstances and to evaluate whether this is a class effect or an individual drug effect, we conducted a prospective population-based cohort study.This study was conducted as part of the Rotterdam Study and included 3377 men
van Noord, C, Straus, SM, Sturkenboom, MC, Hofman, A, Aarnoudse, AJ, BAGNARDI, VINCENZO, Kors, JA, Newton Cheh, C, Witteman, JC, Stricker BH   +9 more
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Bias and Variance Evaluation of QT Interval Correction Methods

Journal of Biopharmaceutical Statistics, 2008
There is an increasing regulatory emphasis on assessing drug-induced QT interval prolongation. Since QT interval is correlated with heart rate (HR), assessment of drug-induced QT interval prolongation should be made at a standardized HR, resulting in the need to correct QT interval (QTc) for HR. This study investigates the statistical properties of QTc
Yibin, Wang, Guohua, Pan, Alfred, Balch
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Transient Prolonged Corrected QT interval in Lyme Disease

The Journal of Pediatrics, 2006
Lyme disease, caused by the spirochete Borrelia burgdorferi, has known cardiovascular effects typically manifesting in varying degrees of atrioventricular block. Three patients presented with QT interval prolongation associated with Lyme disease, a previously unreported manifestation of Lyme carditis.
Stephen P, Seslar, Charles I, Berul, Thomas R, Burklow, Frank, Cecchin, Mark E, Alexander   +4 more
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